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Coding and non-coding sequences are expected to have very different patterns of sequence changes because of the following characteristics of coding sequences: biased codon composition, higher conservation, absence of stop codons and frameshifts, higher fraction of synonymous than nonsynonymous substitutions, higher frequency of substitutions corresponding to changes of chemically similar amino acids, higher proportion of mutable contexts.

我们可以预期可转录的序列及不可转录的序列会有相当不同的序列改变特徵,因为可转录的序列有以下特色:偏颇的密码子组成,较高的保存度,有终止密码子和移码的出现,相较於异义取代有较高比例的同义取代,较高的频率出现化学结构相似的胺基酸取代,较高比例的可变之前后序列。

Nonvascular changes included increased apoptosis (in about 16% of biopsies), fibrous proliferation (in about 4% of biopsies), and villous changes (in 11.4% of distal biopsies).

非血管性改变包括细胞凋亡增多(出现于大约16%的活检中),纤维增生(出现于大约4%的活检中)和绒毛状改变(出现于11.4%的活检中)。

Results showed sTGC-CM, which is similar with the effect of hTGC-CM, was able to induce human DPSCs to make odontoblastic changes as indicated by remarkable morphological changes, increased proliferation ability, higher multipotential and colony forming capability, and expression of some odontogenic markers in gene and protein levels,such as DSP, DSPP, DMP1, BSP, OCN, OPN.

结果表明:人牙髓干细胞经过一定时间的猪牙胚条件培养基诱导后,能在细胞形态上和细胞周期上发生改变,能具有更高的克隆形成能力和多向分化能力,能维持更好的干细胞特性,具有更强的增殖能力,表达更高水平的碱性磷酸酶,免疫组化和RT-PCR提示诱导后的牙髓干细胞能在蛋白水平和基因水平表达出一些牙向分化的标志,如DSP、DSPP、DMP1、BSP、OCN、OPN等。

The extinction or appearance of these Ostracoda always occurred in a short time interval, and can be correlated locally and globally, so they are of importance in bioeventstratigraphy. This article listed six such biological events in Qaidam Basin and discussed their causes. The extinction of Cetacella reflected temperature decrease at global scale and changes of palaeoclimate zones during the latest Jurassic and the earliest Cretaceous; The rapid decline of Cypridea in the earliest Cretaceous may be a result of the strikes of small planets; at the latest middle-Eocene Austrocypris became extinct, and at Oligocene Hemicyprinotus disappeared. These events related to the changes of the geological conditions at that time. The explosion of Cyprideis at the middle-Miocene was because the rise of Qinghai-Xizang Plateau which resulted in the dry climate and development of salt lakes.

这些水生生物的绝灭或发生均很迅速,在区域或全球范围内均可对比,具有生物事件地层学意义:Cetacella属的绝灭可能是侏罗、白垩纪之交全球性的古气候降温和气候带变化在柴达木盆地的反映;早白垩世之后Cypridea的迅速衰退是地外因素灾变的结果;中始新世晚期的Austrocypris的绝灭、渐新世Hemicyprinotus的绝灭都与当时地质条件的改变存在著内在的联系;中中新世Cyprideis的爆发推断是青藏高原隆升,导致气候乾燥、湖水咸化的结果;而晚更新世晚期1。

Objective: To observe the age changes of the age changes of the expression of nitric oxide synthase in pterygopalatine ganglion , otic ganglion and the fibers innervating the cerebral vessels of rats.

目的:观察大鼠翼腭神经节、耳神经节及脑底动脉壁神经纤维一氧化氮合酶表达的年龄变化规律。

Particularly the Cretaceous time period is a time of major changes in the Earth Systems demonstrated by major plate tectonic processes, as is the dispersal of Pangea supercontinent, plaeoclimate and paleoceanography changes.

Berriasian~Albian早期,延续时间超过30Ma;而在Thakkhola地区时代为Hauterivian晚期-Albian早期,延续时间约20Ma,在Zanskar地区火山岩屑砂岩仅仅出现在Albian期,延续时间小于10Ma。

The ani-mal amount of happening hepatic cell necrosis changes in2.00g/kg group was lowered,the degree of pathobiological changes was lightened,and the cell necrosis-changed evaluation had dramatical differences compared with the CCl 4 control group.

结果 0.67g/kg和2.00g/kg剂量组的血清谷丙转氨酶、谷草转氨酶水平降低,与CCl 4 对照组比较(P.05);2.00g/kg剂量组发生肝细胞坏死的动物例数明显减少,病变程度减轻,坏死评分低于CCl 4 对照组(P.01)。

2The animal amount of happening hepatic cell necrosis changes in 2.00g/kg group was lowered,the degree of pathobiological changes was lightened,and the cell necrosis- changed evaluation had dramatical differences compared with the CCl4 control group.

结果 0.67g/kg和2.00g/kg剂量组的血清谷丙转氨酶、谷草转氨酶水平降低,与CCl4对照组比较( P <0.05);2.00g/kg剂量组发生肝细胞坏死的动物例数明显减少,病变程度减轻,坏死评分低於CCl4对照组( P <0.01)。

2The animal amount of happening hepatic cell necrosis changes in 2.00g/kg group was lowered,the degree of pathobiological changes was lightened,and the cell necrosis- changed evaluation had dramatical differences compared with the CCl4 control group.

结果 0.67g/kg和2.00g/kg剂量组的血清谷丙转氨酶、谷草转氨酶水平降低,和CCl4对照组比较( P <0.05);2.00g/kg剂量组发生肝细胞坏死的动物例数明显减少,病变程度减轻,坏死评分低于CCl4对照组( P <0.01)。

2The animal amount of happening hepatic cell necrosis changes in 2.00g/kg group was lowered,the degree of pathobiological changes was lightened,and the cell necrosis- changed evaluation had dramatical differences compared with the CCl4 control group.

结果 0.67g/kg和2.00g/kg剂量组的血清谷丙转氨酶、谷草转氨酶水平降低,与CCl4对照组比较( P <0.05);2.00g/kg剂量组发生肝细胞坏死的动物例数明显减少,病变程度减轻,坏死评分低于CCl4对照组( P <0.01)。

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