查询词典 cathepsin

Selective cathepsin K inhibitor may be new drug for osteoporosis.

另外，选择性的组织蛋白酶K抑制剂可能成为治疗骨质疏松的新药。

Objective To study the expression of cathepsin B in gastric carcinoma and its relationship with the prognostic indexes (tumor histologic types,TNM stages) of gastric carcinoma.

目的研究胃癌组织中组织蛋白酶B的表达及探讨组织蛋白酶B表达与胃癌预后指标(肿瘤组织学类型，TNM分期)的关系。

The new model targeted on Cathepsin K was proved to be feasible and effective in the screening for antiosteoporosis drug.

初筛以抑制木瓜蛋白酶的活性为指标，经筛选从1000株真菌中得到9株具有较强抑制效应的真菌，复筛采用对纯化的组织蛋白酶K的特异性抑制效应为指标。

They found that the important proteins that make up the outer layer of these nanoparticles are degraded by an enzyme called cathepsin L.

纳米技术在医学领域的应用是近年来的研究热点，尤其是将纳米粒子作为一种药物传递工具备受关注。

Specific inhibitor of the Ca2+-dependent cysteine protease calpain I and of cathepsin B and L.

三肽醛。Ca2+依赖性半胱氨酸蛋白酶钙蛋白酶I和组织蛋白酶B和 L专属抑制剂

Positive comedo necrosis was related with c-erbB-2,cathepsin D in tumor epithelial cell and proliferation indexP value was 0.042,0.006 and 0.013 respectively）.

粉刺状坏死的出现，与c-erbB-2癌基因、肿瘤上皮细胞中的组织蛋白酶D和细胞增殖指数相关（P分别为0.042，0.006及0.013）。

With immunohistochemical stained with S-100, the nerve fibres and neuroglia cells are positive.

Cathepsin-D免疫组化结果：神经丛内仅神经元细胞胞浆呈阳性反应，神经纤维和胶质细胞均呈阴性反应。

Pycnodysostosis is an extremely rare genetic osteosclerosis caused by cathepsin K deficiency.

致密成骨不全症是由组织蛋白酶K缺乏所致的一种极为罕见的遗传性骨硬化病。

The result of whole mount in situ hybridization showed that MmeFer was located at the position of shell initiation in trochophore stage, indicating MmeFer plays a role in shell initiation in M. meretrix. The full-length of M. meretrix cathepsin B cDNA was cloned with 3'and 5'RACE. The temporal and spatial expressions of MmeCB mRNA were examined from trochophore to post larva stages by whole mount in situ hybridization. From L2 to L4 stages, MmeCB mRNA was detected in the digestive tract, suggesting a possible role of MmeCB in digestion.

根据构建的文蛤幼虫cDNA文库中提供的序列信息，从文蛤中克隆了与铁离子代谢密切相关的铁蛋白的全长cDNA序列；通过Real time PCR发现，MmeFer mRNA的表达量在贝壳形成前后有明显改变；整体原位杂交结果显示MmeFer mRNA在L1期的表达部位刚好是贝壳生成的起始部位，推断文蛤铁蛋白与文蛤幼虫贝壳初始形成密切相关。

In this paper, we studied M. meretrix ferritin, cathepsin B and caspase genes, which are involved in clam larval shell formation, nutrition, metabolism and apoptosis, respectively. We have cloned the three genes, investigated the temporal and spatial expression profile both at gene and protein level in trochophore (L1), D-veliger (L2), pediveliger (L3) and postlarvae (L4). The potential roles of these proteins were analyzed with specific inhibitors during larval development. Firstly, embryos were found developed into trochophore-like larvae with no shell if cultured at gastrula stage in artificial seawater without iron. Shell-like structures were formed only in the presence of iron. The larvae which had been transferred at L1 stage into ASW developed normal shell. This indicated that iron and iron associated protein are important for larval shell formation. The EST sequence which is homologous with ferritin, which is a principal iron metabolic protein, was selected from the M. meretrix cDNA library. The full-length of ferritin subunit cDNA was cloned by RACE. The results of real-time PCR revealed that the MmeFer mRNA expression changed before and after the larval shell formation.

本论文以文蛤幼虫为研究对象，分别对文蛤幼虫发育过程中贝壳形成相关的铁蛋白、营养及变态相关的组织蛋白酶B及变态过程中细胞凋亡相关的caspase三个基因进行了克隆，分析了基因及编码蛋白在担轮幼虫期(L1)、D形幼虫期(L2)、壳顶幼虫期(L3)和稚贝期(L4)的时空表达特征，解析了其可能的功能，并研究了相应酶类的特异性抑制剂作用对幼虫发育过程的影响，进行了目标蛋白的功能验证，详述如下：研究结果显示，在文蛤胚胎发育到原肠胚时放入不含铁离子的人工海水中培养，发育成无壳的畸形，随着人工海水中铁离子添加浓度的升高，幼虫长出壳状组织接近正常状态；而发育到L1期幼虫放入不含铁离子的人工海水中培养却可以发育出正常的壳，推测铁和铁代谢相关蛋白在幼虫贝壳初始形成有重要的作用。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。