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Cleft palate ; bone defect ; collagen membrane ; guided bone regeneration/GBR ; human recombinant bone morphogenetic protein

腭裂；骨缺损；胶原膜；引导性骨再生；人重组骨形成蛋白

Based on the principle of the Guided Bone Regeneration , our research will focus on regenerating cleft bone defect and reconstructing the integrity of palate by aid of biodegradable collagen membrane and multi-function biological membrane compounded with human recombinant bone morphogenetic protein .

本研究根据引导性组织再生的原理，通过采用可吸收的胶原膜和复合了人重组骨形成蛋白的多功能生物复合膜技术来引导腭部骨缺损处的骨组织再生，以达到在腭裂外科治疗中，对腭部硬组织重建的要求，为腭裂的后续治疗奠定结构基础。

All of above were higher than those of control side.Conclusions ADM can improve the bone quality, increase bone density and intensity and is an ideal guided bone regeneration membrane for alveolar ridge agumentation with TiNi-SMA distraetor.

脱细胞真皮基质作为屏障膜，能提高牵张区成骨质量，增加骨强度，在镍钛记忆合金牵张成骨过程中是一种理想的引导骨再生生物膜。

Result］the operation time was 1～3 h,the operative bleeding quantity were 150～400 ml,all incisions were obtained primary healing.twelve cases were followed up from 6 months to 8 years.the average extremity functional score according to the system of isols（international society of limb salvage）:upper extremity was 22.3 and the lower was 25.3 the average bone healing time of returned deactivation bone graft and bone allograft healing with the osteotomy plane was 3 months,original tumor recurrence in local was 1,the recurrence rate was 7.69%,no malignant change and metabasis was found.

结果］手术时间1～3 h，术中出血量150～400 ml，术后切口一期愈合。12例患者获6个月～8年随访。按isols评分标准评价肢体功能恢复情况：上肢平均22.3分，下肢平均25.3分。灭活回植骨、异体骨与截骨端平均3个月愈合，局部复发1例，复发率7.69%。无恶性变及全身转移。

Early-line treatment of metacarpal bone garft bone open fracture of bone defect made good clinical effect.

早期行骨移植治疗掌指骨开放性骨折骨缺损取得了理想的临床疗效。

Include even a shoulder bone for showing in the X film suspicious 2 places : bone fracture 1, CT showing metatarsus base fracture.flat surface like of 9 clear and definite bone fracture by MRI.

包括X线平片所显示的肱骨上段疑似骨折1处，CT所显示的足跖骨基底部骨折2处。9处为MRI所发现的明确骨折。

Results: Compared test group with control group at 14th day of experiment, test group rats were osteoporotic. The lower bone density figures of test group showed that bones were osteoporotic and test group bone HE microtome section showed that bone trabecula was looser, os integumentale was thiner and chondrocyte was decreased.

结果：实验第14天，模型组与对照组相比，模型组大鼠骨质疏松模型建立成功：骨密度不同程度的降低、骨HE切片中骨小梁稀松、皮质骨变薄、软骨细胞层减少等病理变化。

OBJECTIVE: To summarize the development of bone morphogenetic protein on gene therapy of bone defect in bone tissue engineering.

目的：总结骨形态发生蛋白在骨组织工程基因治疗骨缺损中的进展。

Bone morphogenetic protein gene in bone tissue engineering for bone defect has become a new hot study currently.

骨组织中的骨形态发生蛋白以及骨形态发生蛋白的表达和功能由于他们显著的生物学作用而被长时间的研究。

It was possible to repair segmental bone defects using the living bone devices obtained from non-skeletal sites by taking biphasic porous HA/TCP ceramics as scaffold to"cultivate"bone tissue cells in vivo.

在实验研究的基础上，本课题还进行了40例双相多孔磷酸钙生物陶瓷修复骨缺损的临床尝试，取得了良好的修复和替代效果。

Wenxing consistently adheres to the principle of "trict Management,All Member Participation,Quality First,Users Foremost" and follows the business philosophy of excellent quality,highly active and pursue excellence,thus outdoing its counterparts in terms of technology,production scale and administration.

文兴一贯秉承&严格管理、全员参与、质量第一、用户至上&的企业方针，遵循优质、高效和追求卓越的经营理念，从而实现在技术上、规模上、管理上处于同行领先地位。

The left atrium of the guinea pigs was innervated by the two afferent system.

豚鼠左心房受心脏的两个传入系统的双重支配。