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Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome

目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析,并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography,FFA)、吲哚青绿血管造影(indocyanine green angiography,ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例,73.5%),双眼同时患病118例(80.8%);后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%);前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例,98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%);后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障;毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现;炎症活动期FFA典型表现为斑驳状高荧光,ICGA发现脉络膜血管扩张、通透性增高等改变;VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎,随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。

I carefully looked at the dandelion, it is not a finicky flower.

我仔细看了看蒲公英,它并不是一个娇气的花。

Lived firmly to see the person in house carefully, a lot of is familiar with, also have a lot of unfamiliar, of my know have COO Chen Danian, li Yu of grand game CEO... I just feel this conference is like very grand.

稳住仔细看了屋里的人,有很多熟悉,也有很多不熟悉的,我认得的有COO陈大年,盛大游戏CEO李瑜……我才觉得这个会议好像很隆重。

Carefully add the major dark areas with pencil shading, then look for finer markings.

仔细用铅笔添加主要的暗区,然后寻找一些细小的斑点。

Carefully studied the "Privacy Act" from the United States, Japan's "Personal Information Protection Act","Personal Data Protection Act" from Chinese Taiwan, into a personal information protection in our country should comply with several principles.

并认真研究了美国的《隐私权法》、日本的《个人资讯保护法》、我国台湾地区的《个人资料保护法》,归纳出我国在个人信息保护中应遵守的几大原则。

The Kuomintang officials carefully explained they had taken the pictures from the dead soldier's pockets, just a few days before.

国民党官员煞费苦心地解释说,这些照片是几天前才从这个士兵尸体的衣袋里找出来的。

Now the perils of the Dungeons are many, and some time later, when Iolo entered Despise (more carefully than Edric had, for Iolo knew the place of old), he was soon greeted by a black and gaping deadfall.

地下城里的危险很多,不久以后,当Iolo进入"轻视"时(比Edric更为小心,因为Iolo早就知道这地方了),他很快就遇到了黑色且多洞穴的"死伏"(陷阱的一种,一堆交错倒下的树木)。

It is a hygienic and physiological fact that tobacco produces sexual debility and those who suffer any weakness on that source should carefully avoid the weed in all its forms.

这是一个卫生和生理的事实,烟草生产性debility和那些谁遭受任何弱点,对这一来源的,应仔细,避免杂草在其所有形式。

He found out that some of these external manifestations were being carefully practised at home, while some were the outcome of malnutrition, mental weakness, or nervous debility.

他发现其中的一些外部表现已经在家中仔细地实践过,而另一些则是营养失调、精神软弱或者神经衰弱的结果。

We need to debrief him very carefully.

我们得小心翼翼地盘问他

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口,替代木托盘,免薰蒸,符合欧盟、北美各国对出口货物包装材料的法令要求;喷涂钢托盘适用于重载上货架之用,托盘表面根据需要制作成平板状、波纹状及间隔形式,满足不同的使用要求。

A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。