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Result] Under blood stasis, it can to some extent inhibit the production of primary cancer, the serum IL18 and HGF were reduced in mouse of liver metastasis with cancer, which may intervene the liver metastasis; Shensanqi extract had some definite function on the primary cancer of spleen and liver metastasis of rats with liver metastasis of cancer, the platelet exerted key functions in cancer hyperplasia, infiltration and metastasis.

结果]在血瘀状态下,可在一定程度上抑制原发肿瘤的生长,荷瘤肝转移小鼠血清IL18和HGF的水平降低,可能干预了肝转移的过程,参三七醇提液对荷瘤肝转移大鼠的脾脏原发肿瘤的生长和肝转移有一定抑制作用,血小板在肿瘤增殖、浸润和转移中起着重要作用。

objective to observe the antitumor activities of different solution extracts of plumbago zeylanica l.in vitro.method mtt method was used to detect the inhibitory effects on four kinds of cancer cells.results chloroform extracts had significant inhibitory effects on the breast cancer cell(bre-04),the nerve cancer cell(n-04) and the lung cancer cell(lu-04),ic50 were 0.2699mg/ml and 0.2634mg/ml,0.4961mg/ml respectively.ic50 of chloroform extract on the hepg2 was 0.9379mg/ml.ic50 of petroleum ether extracts on bre-04,n-04,lu-04 and hepg2 was 0.5902mg/ml,0.5725mg/ml,0.7938mg/ml,0.6374mg/ml;ethyl acetate extracts had fairly inhibitory effects on the lu-04,ic50 was 0.7343mg/ml;n-butanol extracts and water-solubility extracts had notsignificant inhibitory effects on the four kinds of cancer cells.conclusion the antineoplastic effective parts of plumbago zeylanica l.were chloroform and petroleum ether extracts.

目的 探讨白花丹体外抗肿瘤作用的活性部位。方法 mtt染色法对白花丹五种溶剂提取物体外抗肿瘤活性进行了初步的研究。结果氯仿提取物对乳腺癌细胞(bre-04)、神经癌细胞(n-04)、肺癌细胞(lu-04)有较好的抑制生长作用,ic50分别为0.269 9 mg/ml、0.263 4 mg/ml、0.496 1 mg/ml,对肝癌细胞hepg2抑制作用差, ic50为0.937 9 mg/ml;白花丹石油醚提取部位对乳腺癌细胞(bre-04)、神经癌细胞(n-04)、肺癌细胞(lu-04)、肝癌细胞hepg2的ic50分别为0.590 2 mg/ml、0.572 5 mg/ml、0.793 8 mg/ml、0.637 4 mg/ml;乙酸乙酯提取物对肺癌细胞(lu-04)有一定的抑制作用,ic50为0.734 3 mg/ml;水溶性提取物以及正丁醇提取物无明显抑制肿瘤作用。结论白花丹氯仿提取部位、石油醚提取部位体外抗肿瘤作用较好,值得对其提取部位进一步分离纯化并研究其抗肿瘤作用机制。

Conclusion] Lung cancer, stomach cancer, esophageal cancer and liver cancer are the common causes of cancer death in registration area.

结论] 肺癌、胃癌、食管癌、肝癌是我国登记地区居民主要恶性肿瘤死亡原因。

Breast cancer is the fourth leading cause of cancer death for Taiwanese women. X-ray mammography is currently the most effective method for an early diagnosis of the breast cancer. The existence of spicules is one of most important visual signs for breast cancer diagnosis. Spiculation is a stellate distortion caused by the intrusion of breast cancer into surrounding tissue. In general, malignant tumors appear with rough and complex boundaries or contours, whereas benign masses present smooth, round, or oval contours.In this paper, we present a technique to detect the contours of spiculated lesions from the regions of interest in a mammographic image.

中文摘要乳癌是是我国妇癌症死亡主因的第四位,乳癌诊断程序中,乳房X光摄影为临床上医生诊断乳癌的利器,在诊断乳房摄影肿瘤的影像时,可用特徵决定为良性或恶性肿瘤,良性肿瘤通常会呈现圆滑的特徵,而恶性肿瘤则呈现星状或不规则不平滑特徵,这种星状或不规则不平滑特徵组织,称为星状物肿瘤,指的是肿瘤周围的乳腺组织,因星状物往外侵犯的关系造成的变形,星状物的存在是恶性肿瘤判断的依据。

Investigations have approved that selenium is the trenchancy inhibitor of galactophore cancer, liver cancer, skin cancer, colon cancer and stomach cancer, some investigations in outside of body indicated that the induction of differentiation in a number of tumour cell lines by Retinoic acid and Sodium selenite had taken out adding effects, namely, the rate of induction of differentiation and inhibition of proliferation on malignant tumors by the associated application of two different sorts medicaments is approximately double towards by the every one.

体外研究的一些结果表明维甲酸与亚硒酸钠对一些肿瘤细胞株的诱导分化有加和作用,即两种药物联合应用,其对恶性细胞的诱导分化率和生长抑制率是单独应用一种药物的效果的近似两倍。

Since there were 10 more unscreened cancer patients and 5 more cervical cancer deaths in the cytology arm than in the HPV arm and since these unscreened cancer patients predictably had higher rates of cervical cancer, more advanced stages, and less favorable outcomes, the net effect of the inclusion of the larger number of unscreened cervical cancer patients in the cytology arm was to make the cytology arm appear more like the unscreened control arm of the study.

由于在细胞学组中有10个未筛查的宫颈癌病人和5个宫颈癌死亡者,高于 HPV 组,同时因这些未筛查的宫颈癌病人预期有较高的宫颈癌发生率,更加进展的临床分期和较差的预后,因而大量未筛查的宫颈癌病人在细胞学组中,这样结果的净效应是细胞学组更像本研究中未筛查对照组。

Pathologically, cancer of intestine is adenocarcinoma which can cytologically be classified into encephaloid cancer, hard cancer, cancer of mucous gland and papillary cancer .

从病理学来说,肠癌其实是腺癌,细胞学上分为脑癌、硬癌、粘液腺癌和乳头状癌。

To mensurate the expression of MDR1 of different breast cancer cells from human breast cancer primary cells and MCF-7 breast cancer cell line,and the kill effect of chemotherapy drug with different breast cancer cells in vitro,and the change of the proporation and the expression of MDR1 of breast cancer stem cells after chemotherapy.

测定人乳腺癌标本和MCF-7中不同细胞亚群的MDR1表达情况;并测定化疗药物在体外对人乳腺癌原代细胞和MCF-7中不同细胞亚群的杀伤作用,以及在化疗药物干预后,乳腺癌干细胞的含量和MDR1表达的变化情况。

Methods Malignant tumor tissues were obtained from 11 patients with colon cancer, 15 patients with cervical cancer, 10 patients with breast cancer, 9 patients with esophageal cancer, 12 patients with lung cancer and 16 patients with gastric carcinoma. Nonmalignant tissue was used as negative control. Three tumor cell lines were also studied. Hfgl 2 was examined both at the level of mRNA and protein by immunohistochemistry as well as RT-PCR.

采用免疫组化方法检测了11例结肠癌、15例宫颈癌、10例乳腺癌、9例食管癌、12例肺癌、16例胃癌患者的病理组织切片中hfgl 2及纤维蛋白的表达,分析二者的组织学关系,用RT-PCR方法检测了部分肿瘤组织与肿瘤细胞系中的hfgl 2 mRNA。

Urologic cancer surgeons need to think about maintaining long-term kidney function, because that might ultimately affect the overall survival of these patients."The oncologic data are clear," Dr. Blute said. The cancer survival rates are identical for partial and radical nephrectomy, but these new data suggest that there might be a difference in overall survival."This is a cancer database, so we only know that these patients didn't die from cancer, but we don't know what they died from," he explained."Further study is necessary in a population of possible kidney cancer patients who have a history of smoking, diabetes, hypertension, or obesity, which are exactly the conditions that predispose to chronic kidney disease."

泌尿外科医师应该考虑维持长期的肾脏功能,因为这可能最终影响这些病患的整体存活率;Blute医师表示,肿瘤学的数据是清楚的,接受部分与全肾脏切除的癌症存活率是相同的,但这些新数据显示整体的存活率可能有差异,他解释,这是个癌症资料库,因此我们仅知道这些病患并未死于癌症,但是我们不知道他们死于何种原因;未来的研究需要针对有吸菸、糖尿病、高血压、或是肥胖病史,这些状况可能造成慢性肾脏疾病,且可能是罹患肾脏肿瘤的病患进行进一步的研究。

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