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RESULTS: Compared with acupuncture and Chinese herb used separately, acupuncture and herb combination significantly decreased the level of reduced viscosity in whole blood, plasma viscosity, blood sedimentation and erythroagglutination index..Significant increases of TMPH in the heart, liver and hind paw tissue except kidney were observed after the combined treatment, which also raise cAMP level in heart and liver.

结果：针药组大鼠的全血还原粘度、血浆粘度、血沉、红细胞聚集指数均较单纯针刺组、单纯药物组显著降低；单位时间内针药组大鼠体内(心脏、肝脏、病灶局部组织)盐酸川芎嗪含量明显高于单纯药物组，肾脏中却无明显增高；同时针药组大鼠心脏、肝脏中的cAMP含量明显高于单纯针刺组和单纯药物组。

FOXC2 affects adipocyte metabolism by increasing the sensitivity of the β-adrenergic-cAMP-protein kinase A signaling pathway through alteration of adipocyte PKA holoenzyme composition.

FOXC2通过对各种参与代谢重要基因的调控和提高β-肾上腺素能－cAMP-蛋白激酶A信号通路的敏感性，改变脂肪细胞PKA全酶的组成来影响脂肪细胞的代谢。

Results The pD2 value (the affinity to M-receptors of agonist) of Erycibele alkaloid's miosis is 3.60±0.15 and its IOP lowering action is 3.49±0.07. In the isolated iris contracting experiment, its pD2 value is 6.38±0.12. M3 receptor antagonist is the strongest antagonist in inhibiting the miosis, IOP lowering action and isolated iris pupillary contracting action of Erycibele alkaloid. 0.01% Erycibele alkaloid can cause the decrease of cAMP and the increase of cGMP in the aqueous humor.

结果 测定丁公藤碱缩瞳作用的pD2值为3.60±0.15，降眼压作用的pD2值为3.49±0.07，离体虹膜收缩作用的pD2值为6.38±0.12.M1～M3受体拮抗剂均可拮抗丁公藤碱的缩瞳作用、降眼压作用及离体虹膜收缩作用，其中以M3受体拮抗剂的拮抗作用最强。0.01％丁公藤碱可使房水环磷酸腺苷(cyclic adenosine monophosphate，cAMP)含量降低，环磷酸鸟苷(cyclic guanosine 3，5-monophosphate；cGMP)含量升高。

These results suggest that the prescription reciped based on the theory of the correlation between spleen-stomach and mentality can effectively hold back the epileptogenesis. The antiepileptic mechanism of the prescription may relate with reducing the release of monoamines; regulating the level of cAMP and cGMP and diminishing gene and protein expression of c-fos、c-jun.

本文研究结果提示，根据脾胃与神志相关理论，以调理脾胃为主旨组成的复方能有效阻抗PTZ点燃大鼠EP发作；其抗痫机理可能与减少单胺类神经递质的释放、调节cAMP、cGMP水平，进而削弱c-fos、c-jun基因及蛋白的表达有关。

［Ca2+］, CaM, cAMP and Ca2+/CaM-PK Ⅱ exert important role in the damage of PC12 after combined soman and hypoxia injury.

［Ca2+］、cAMP、CaM和Ca2+/CaM-PK Ⅱ在缺氧复合梭曼中毒PC12细胞损伤机制中起了重要的作用。

Objective To observe the changes of the concentration of Ca2+, contents of cAMP, CaM and activity of Ca2+/CaM-PK II in pheochromocytoma PC12 cells after combined soman and hypoxia injury.

目的 观察缺氧复合梭曼中毒后大鼠肾上腺嗜铬细胞瘤PC12细胞内游离钙的浓度(［Ca2+］)、cAMP、钙调蛋白和钙调蛋白激酶Ⅱ（Ca2+/CaM-PK Ⅱ）的变化。

Results The changes of ［Ca2+］, the contents of CaM, cAMP were significantly higher in hypoxic and soman intoxicated group than in soman intoxicated group and control group under hypoxia; but the activity of Ca2+/CaM-PK Ⅱ were significantly decreased.

结果 缺氧中毒组PC12细胞cAMP、CaM含量在中毒后24 h明显高于单纯中毒组、缺氧对照组和正常对照组；缺氧中毒组PC12细胞Ca2+/CaM-PK Ⅱ活性在中毒后24 h明显低于单纯中毒组、缺氧对照组和正常对照组。

In human vascular smoothe muscle cells and glial cell tumors, ADM suppressed cell growth and increased intracellular cAMP.

对于人的血管平滑肌细胞和胶质细胞，ADM抑制其细胞增殖并增加细胞内cAMP水平。

After amplying a 2.2kb fragment form the PPV-SC1 RF-DNA,we clone the fragment into pMD 18-T,named pTNSl.The whole sequence which is 1989 bp long was determined by sequencing, including the complete ORF of PPV-SC1 NS1 which encoding 662 amino acids.Alignment of pairs of sequence indicates that there are 98% and 99% similary with other porcine parvovirus strains Kresse and NADL-2, respectively. Multiple sequence alignment discloses that there are a few difference between ppv-scl nsl gene and other ppv nsl gene: A-G at 39nt,T-C at 153nt,A-G at 175nt, A-C at 1117nt, A-C at 1535nt .Alternative codon in ppv-scl nsl have distinctly different frequentfy by codonbias analysis at EMBOSS(http://genopole.toulouse.inra.fr/bioinfo/emboss). Thereis not distinct hydrophobicity and transmenbrane helices in ppv-scl nsl protein. Struction domain anslysis of PPV-SC1 NS1 protein indicate that there are a ATP/GTP-binding site motif A at 398-405,16 Protein kinase C phosphorylation site,21 Casein kinase II phosphorylation site,and 3 cAMP/cGMP-dependent protein kinase phosphorylation site.At the same time ,there is a same motif between ppv-scl nsl and Poxvirus D5 protein-like which may share in the same fuction which is necessary during virion duplication.

将PPV-SC1 NS1序列与其他PPV NS1基因进行多序列比对，结果显示，PPV-SC1 NS1与其他的PPV NS1的同源性较高，仅存在个别的差异，分别是第39位A→G，第153位T→C，第175位A→G，第1117位A→C，第1535位A→C；同源搜索比较表明，PPV-SC1与PPV NS1同源性可达98％、99％，与其他的细小病毒NS1基因也存在很大的保守性；密码子偏向性分析结果表明PPV-SC1 NS1基因在同一氨基酸的不同密码子的选择上存在一定的偏向性；PPV-SC1 NS1蛋白总体上说具有亲水性不存在明显的疏水性区段，用swiss TMPRED软件预测PPV-SC1 NS1的跨膜区，返回的结果并没有得到有显著意义的跨膜区的存在；根据基于motif数据库的结构域预测，PPV-SC1 NS1的第393-415位氨基酸残基存在潜在的ATP／GTP结合位点，该蛋白还存在16个蛋白激酶C磷酸化位点，21个酪蛋白激酶2磷酸化位点，3个cAMP-／cGMP依赖蛋白激酶磷酸化位点，PPV-SC1 NS1蛋白与POX_D5(痘病毒D5蛋白)具有一致的保守结构域，推测NS1可能与POX_D5有类似的功能。

Aim: To study the effects of 8-Br-cAMP on oncogene and anti-oncogene in human Hela cells.

目的：探讨8-Br-cAMP对Hela细胞癌基因和抑癌基因等表达的影响。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。