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CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

来源：ABCca论文02网www.abclunwen.com

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

By methods of indirectly labelling with NaH〓PO〓 and directly labelling in atomic pile, Ca〓-P, Ca〓-P, Ca〓-P, Fe-P and A1-P were isotopically labelled.

试验结果进一步证明，菌丝际的土壤pH有所降低（0.2-0.4个单位）；磷酸二钙和磷酸八钙处理的菌丝际土壤溶液中磷浓度显著地高于基他处理。

The PKC family is subdivided into three groups; the classical PKC members are Ca〓 and diacylglycerol dependent, the novel PKCn are Ca〓-independent but diacylglycerol dependent and the atypical PKCs are not activated by Ca〓and diacylglycerol in vitro.

丝裂素活化蛋白激酶是一族在脊椎类动物体内广泛存在的蛋白质丝氨酸/苏氨酸激酶，是目前发现的最主要的一个生长信号调节蛋白，是细胞内多种促细胞增殖信息传递的共同通路或称会聚点，是细胞表型变化和增殖的蛋白激酶。

ER is well characterized as a mobilizable calcium store that sequesters excess cytosolic calcium and a reservoir for calcium signaling to maintain intracellular Ca2+ homeostasis.

2钙离子的检测 1、细胞内质网是[Ca~(2+)]_i的主要储存场所，以及[Ca~(2+)]_i在细胞凋亡的信号转导通路中所具有的重要作用，本实验研究了SfaMNPV诱导SL-1细胞凋亡过程中细胞内[Ca~(2+)]_i的变化以及[Ca~(2+)]_i可能在凋亡信号转导通路中的意义。

Corolla purple-red or reddish, ca. 1.7 cm, puberulent; tube ca. 1.3 cm, throat ca. 3 mm wide, annulus absent; upper lip densely purple-red pubescent on outside, straight, oblong, ca. 4 mm, apex slightly curved; lower lip slightly longer; middle lobe obcordate, 2-lobulate.

花冠紫红色或带红色，约厘米，被微柔毛； 1.3厘米的约筒部，喉约3毫米宽，缺席；在外面，直，长圆形，约4毫米，先端稍弯曲上的浓密的上唇紫红色短柔毛；下唇稍长；中部裂片倒心形，2具小裂片。

Pillared montmorillonite, as a representative of Sandwich like pillared interlayered clays ,caught many scientist"s attention not only because of its special structure of two-dimensional sheets but also its excellent activity of catalysis and adsorption. It is well documented that the method to prepare PILM, ion-exchanging, needed a long periods and was affected by many factors, and that the product had low thermal stability especially hydro-thermal stability which was the primary obstruction of its using in large-scale production. At the same time, PILM was well documented prepared with Na-montmorillonite, while there were a few documents about PILM prepared with Ca-montmorillonite. The large cost of remodel of Ca-montmorillonite to Na-montmorillonite was another obstacle of the application of PILM, while Ca-montmorillonite was widely distributed in nature, as a result, to prepare PILM with Ca-montmorillonite has practical significance. What"s more, PILM was mainly studied as a catalyst in oil refining process till now, but rarely documented in other catalysis reactions, especially in coal liquification filed which also needed high activity catalyst.

以柱撑蒙脱石为代表的具有&三明治&结构的柱撑粘土矿物因其特殊的二维孔道结构和优良的催化和吸附性能近年来成为国内外广泛关注和研究的热点，但是目前国内外大量报道的PILM制备大多采用离子交换法，生产周期很长，影响因素很多，并且产物热稳定性不够高，特别是水热稳定性较差，这是其不能在实际中大规模生产和应用的主要障碍，因此制备一种高稳定性的PILM意义非常；文献中大量报道的都是钠基蒙脱石合成的柱撑粘土矿物，传统的离子交换法必须将钙基蒙脱石钠化改型，其成本相当高，而自然界中大量存在的却是钙基蒙脱石，直接用钙基蒙脱石合成柱撑粘土矿物有很现实的意义，但目前这方面的报道却很少见；另外，迄今为止，PILM作为催化剂的研究领域主要在石油的炼制中应用，而在煤炭的液化中却鲜有报道，如果能在煤炭转化领域应用这一成果，其影响也将是相当大的。

Pillared montmorillonite, as a representative of Sandwich like pillared interlayered clays ,caught many scientist's attention not only because of its special structure of two-dimensional sheets but also its excellent activity of catalysis and adsorption. It is well documented that the method to prepare PILM, ion-exchanging, needed a long periods and was affected by many factors, and that the product had low thermal stability especially hydro-thermal stability which was the primary obstruction of its using in large-scale production. At the same time, PILM was well documented prepared with Na-montmorillonite, while there were a few documents about PILM prepared with Ca-montmorillonite. The large cost of remodel of Ca-montmorillonite to Na-montmorillonite was another obstacle of the application of PILM, while Ca-montmorillonite was widely distributed in nature, as a result, to prepare PILM with Ca-montmorillonite has practical significance. What's more, PILM was mainly studied as a catalyst in oil refinin g process till now, but rarely documented in other catalysis reactions, especially in coal liquification filed which also needed high activity catalyst.

以柱撑蒙脱石为代表的具有&三明治&结构的柱撑粘土矿物因其特殊的二维孔道结构和优良的催化和吸附性能近年来成为国内外广泛关注和研究的热点，但是目前国内外大量报道的PILM制备大多采用离子交换法，生产周期很长，影响因素很多，并且产物热稳定性不够高，特别是水热稳定性较差，这是其不能在实际中大规模生产和应用的主要障碍，因此制备一种高稳定性的PILM意义非常；文献中大量报道的都是钠基蒙脱石合成的柱撑粘土矿物，传统的离子交换法必须将钙基蒙脱石钠化改型，其成本相当高，而自然界中大量存在的却是钙基蒙脱石，直接用钙基蒙脱石合成柱撑粘土矿物有很现实的意义，但目前这方面的报道却很少见；另外，迄今为止，PILM作为催化剂的研究领域主要在石油的炼制中应用，而在煤炭的液化中却鲜有报道，如果能在煤炭转化领域应用这一成果，其影响也将是相当大的。

Activation of the surface DORs causes a slow Ca〓 elevation by both inositol 1, 4, 5-trisphosphate receptor-mediated intracellular Ca〓 release and extracellular Ca〓 entry, resulting in a slow and long-lasting increase in intracellular Ca〓, exocytosis, DOR insertion and CGRP release.

激活DOR引起的DOR的上膜是依赖于LDCV与细胞膜的融合和细胞内的钙离子升高。激活DORs可以引起胞内IP3钙库的释放，和一种不通过电压依赖性钙通道的外钙内流；从而引起DOR的上膜和神经肽的分泌。

Culms ca. 8 m, ca. 2.5 cm in diam.; internodes dull purple-green, becoming green with lower internodes tinged purple, to 35 cm, initially white powdery; wall ca. 5 mm thick; nodal ridge slightly elevated, as prominent as sheath scar; intranode ca. 5 mm. Culm sheaths pale red-brown, sometimes tinged green, sparsely to densely speckled, dark brown and glabrous along margins, sparsely strigose; auricles and oral setae well developed, purple; ligule purple, truncate to arcuate, short but broad, margin fringed with purple-tinged cilia; blade reflexed, purple to green, crinkled.

秆约8米，约厘米直径；节间愚笨紫色绿色，变得绿色与低节间紫色地微染着，令35厘米的是，最初白色粉状；壁约5毫米厚；节的稍隆起脊，象鞘痕一样突出； intranode约5毫米竿箨浅红棕色，有时微染绿色，疏生对浓密有斑点，暗褐色和沿边缘，疏生糙伏毛；叶耳和口头的刚毛发育良好，紫色；叶舌紫色，削去到弧曲，短但是辽阔，用紫色微染的cilia作为边缘的边；叶片反折，对绿色，皱曲紫色。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。