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The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用,阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制,我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响;以Lewis肺癌自发性转移为模型,考察了托吡酯对肿瘤生长和转移的影响;同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响;检测了其对血管新生的作用;利用体外AQP1表达模型,研究了CA抑制剂对AQP1功能的影响;此外,用蛋白质组学的关键技术,通过对模型组与托吡酯治疗组血清蛋白质组的比较分析,来寻找与肿瘤转移相关的蛋白质,探索托吡酯的可能作用靶点。

The cytoplasm of the tapetum cells of Zhenshan 97A deposited a few Ca(superscript 2+) precipitates at the pollen mother cell stage. At the meiosis stage, there were many large Ca(superscript 2+) precipitates at the inner longitudinal cell wall; there were a layer Ca(superscript 2+) precipitates around the tapetal cells.

珍汕97A绒毡层细胞从花粉母细胞时期开始,细胞质内有少量颗粒状的Ca(上标 2+)沉淀;减数分裂时期,绒毡层细胞的内切向壁表面有大量大颗粒的Ca(上标 2+)沉淀;单核花粉时期绒毡层细胞周围集聚一层Ca(上标 2+)沉淀。

The amount of different mineral elements in different parts of male and famale B. thoracica had big difference, except Zn; the amount of other mineral elements in female breast muscle were all higher than that in male breast muscle, and the amount of Ca, Fe in leg muscle, Ca, Cu, Mn in skeleton and Cu, Mn in feathers of male were all higher than that of female, but the amount of Ca, Fe, Zn in feathers of female were higher than that of male.

雌雄个体不同部位、不同矿质元素含量存在较大差异,除Zn外,雌性胸肌中其他元素的含量高于雄性,雄性腿肌中Ca、Fe含量、骨骼中Ca、Cu、Mn含量、羽毛中Cu、Mn含量均高于雌性,雌性羽毛中Ca、Fe、Zn含量高于雄性。

The process of translocating Ca2+ from fruit surface into pulp tissue could be accelerated by IAA,GA or NAA, which also led to an increment on 2%HOAc extractable Ca. Meanwhile, the Ca existed in the stalk and leaves could be excessively transported into fruits by applying IAA on the fruit surface, resulting in too much accumulation of Ca in fruit and bad quality of fruit, while no such effects were observed in those with GA or NAA.

IAA、GA和NAA均可促进果面钙运往果实内,并导致2%HOAc提取钙与5%HCl提取钙组分增加,IAA虽可促进大量的树体钙向果实转移,却会导致果实钙含量过高,品质变差;GA和NAA则不能夺取树体内的钙,对果实品质无不良影响。

The calculated results show that azido in azides has linear structure , the most optimized CaN6 has linear structure , and the most optimized (CaN6)n (n=2~5) clusters have chain structure of perpendicularity of approximate diamond composed by two azido with two Ca atoms . The middle N atoms of azido show positive, the N atoms at both ends of azido show negative, and the N atoms effected with Ca atoms directly show more negative . There is strong ionic bond between the Ca and N atoms. The IR spectra of the most optimized (CaN6)n (n=1~5) clusters have four vibrational sections , the whole strongest vibrational peak lies in 2195~2280cm-1,and the vibrational mode is anti-symmetric stretching vibration of N-N bonds in azido . Stability analysis show that (CaN6)3 and (CaN6)5 clusters are more stable than other clusters .

结果表明,叠氮化合物中叠氮基以直线型存在,CaN6团簇的最稳定结构为线型结构,(CaN6)n(n=2~5)团簇首先由两个叠氮基与两个Ca原子构成一个近似菱形,再由菱形相互垂直形成链状最稳定结构;叠氮基中间的N原子显示正电性,两端的N原子显示负电性,且与Ca直接作用的N原子负电性更强,金属Ca原子和N原子之间形成很强的离子键;(CaN6)n(n=1~5)团簇最稳定结构的IR光谱分为4个部分,其最强振动峰均位于2195~2280cm-1,振动模式为叠氮基中N-N键的反对称伸缩振动;稳定性分析显示,(CaN6)3和(CaN6)5团簇相对于其他团簇较为稳定。

Studies of using Ca〓 channel blockers and the Ca〓 chelator EGTA further demonstrated that Ca〓 also involved in signal transduction of NO-induced stomatal closure.

使用钙的螯合剂、质膜Ca〓通道的阻断剂NIF和LaCl〓及细胞内Ca〓通道的抑制剂进一步证明Ca〓也参与NO诱导气孔关闭的信号转导。

Leaves 2 or 3 per ultimate branch; auricles minute or absent; oral setae short; ligule exserted; blade ca. 12 × 1.4 cm. Flowering branchlets spicate, ca. 8.5 cm, scaly bracts ca. 4, gradually larger; spathes 4 or 5, glabrous or sparsely puberulous; auricles and oral setae absent, blade subulate, small.

每末级的分枝留下2或3;叶耳小或无;口头的刚毛短;叶舌外露;约叶片1.4 厘米花小枝12×穗状,约厘米,约有鳞苞片,逐渐大;佛焰苞4或5,无毛的或疏生微柔毛;叶耳和口头刚毛无,叶片,小。

Based on the study of chronology and geochemistry of Cd in sediments of the Dongting lake area, we have established an ARIMA model of Cd and Cd/Ca in Quaternary and Holocene period respectively, and discussed Cd evolutionary regularity according to the fitted value and predicted value of the model The results revealed that the Cd evolution has remarkable periodicity of ecogeochemistry cycles, and is correlated with the climate change of alternative cold and warm Cd/Ca is changed with climate, from which the evolutionary history of regional ecogeochemistry can be inferred The changes of Cd and Cd/Ca are basically simultaneous, which showed that the change of Cd is mainly a natural evolution Cd in sediments will rise in the next 30 years and then tend to decrease From the regularity of ecogeochemistry indexes and global environment variation, it is concluded that the natural environment is the dominant factor affecting the Cd deposition

在对洞庭湖区沉积物钻探取样的年代学和地球化学研究基础上,分别建立第四纪和全新世时期Cd和Cd/Ca的时间序列演化ARIMA模型,并据模型的拟合值及未来预测值对区域地球化学环境中Cd的演化规律进行了探讨,结果显示区内Cd的演化有较显著的周期性--环境地球化学旋回,与气候多次冷暖的交替有关;沉积物Cd/Ca受气候环境等控制,分析该比值的变化规律可推测区域环境地球化学的演变历史;Cd和Cd/Ca两者的变化基本同步,说明该区Cd的演化主要为自然演化;未来30年内沉积层的Cd含量仍有逐渐增高的趋势,之后转为降低。从本区环境地球化学指标的时间变化规律及其与全球环境变化的相关联中说明自然条件是区域镉等元素沉积的主控因素。

Some of the most popular vacation spots include New York City, Washington D.C., Disney World FL, DisneyLand Ca, Niagara Falls, NY, Universal Studios, Hollywood, Ca, San Francisco, CA, The Grand Canyon, AZ, Cape Cod, MA, and The Great Smoky Mountains National Park, TN.

最受欢迎的度假景点如纽约市,华盛顿特区,位于佛罗里达州的迪斯尼世界,加利福尼亚的迪斯尼乐园,纽约的尼亚加拉瀑布,加利福尼亚的好莱坞环球影视城,加州的旧金山,亚利桑那洲的科罗拉多大峡谷,马萨诸塞州鳕鱼岬市,田纳西洲的大烟山国家公园。

Company has 8 sets Vertical Machining Center, 1 set Horizontal Machining Center, 6 sets NC lathe, 1 set O.D. Grinding machine, 1 set Plane Grinding machine, 3 sets EDM, 1 set CMM, 1 set universal tool microscope, 1 set cutter aligner, 1 set roughness instrument, etc., much of equipments are the most advanced in domestic.

主要 设备有:加工中心9台(最大加工范围800mm)、数控车床6台(最大加工直径360mm)、外圆磨、平面磨、慢走丝线切割机、快走丝线切割机,电火花成形机、三维坐标测量仪、万能工具显微镜,精密对刀仪、粗糙度仪等。

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As of Tuesday, Google's results were still censored in China.

截至周二,谷歌的搜索结果仍受中国审查。

In order to make the positive action increase and negative one decrease, the sub-forces of the social factors must be adjusted to form a centripetal force.

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