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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

The rough fate of pure jurisprudence in China is a process of animadversion and inheritance,and an epitome of Chinese constitutionalism and rule of law.

纯粹法学在中国的坎坷命运,既是一个批判与继承的过程,也是中国宪政与法治的一个缩影。

Its healing method through "animal magnetism" and work with trance-induced states was seen as another proof that mind could rule matter.

在新思想和基督教科学运动中,一些这样的思想也能找到。

Ethnic and cultural differences between the Muslim north and the mainly Christian and animist south have remained deep in the 53 years since Sudan's independence from British colonial rule.

北方的穆斯林集团和南方主要的基督教和泛灵论集团之间的种族和文化差异自苏丹从英国殖民统治之下独立开始已经根深蒂固地存在了53年。

After 1956, when the country gained independence, the south, which is Christian and animist, was in an almost permanent state of rebellion against the Muslim Arab north, demanding a bigger share of the national wealth and a greater degree of self-rule.

自1956年苏丹独立之后,南部就是基督教信众与动物保护主义者的天下,他们要求占有更大份额的国家财富以及更大的自治度。

In September will release "Steel and iron Profession Annexation Reorganization Rule" will have certain function regarding this.

宝钢在全国的战略,也许会有新的方向。

As a general rule, gas planets that orbit larger, more luminous stars tend to be puffier, but this does not explain TrES-4's anomalously large size.

通常,围绕更大、更明亮的恒星旋转的气态行星往往会膨胀得更厉害,但这也无法解释 TrES-4异常巨大的体积。

The specific heat,the enthalpy and the density of liquid Au-Cu and Ti-Al alloys behave anomalously,and the Neuman-Kopp rule does not apply to these two bianary systems.

对Au-Cu和Ti-Al合金的比热和密度进行了系统的模拟,发现比热和密度偏离理想行为,Neuman-Kopp定律不适用。

Then, the antecedence and consequence of a fuzzy rule are referred to as a combination of linguistic values and the corresponding utility of the antecedent part, respectively.

此外,产品的意义并限定为实物,而是广泛的解释为一可被评估之对象。

Generally speaking, Anteriority and Posteriority express foreground, Simultaneity expresses background, the dynamic express foreground and the static express background. The Tense forms of Chinese reflect this rule and have some change.

一般而言,异时表前景,同时表背景,动态表前景,静态表背景,汉语的各表"时"手段既体现了这一规律又有所变化。

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推荐网络例句

As of Tuesday, Google's results were still censored in China.

截至周二,谷歌的搜索结果仍受中国审查。

In order to make the positive action increase and negative one decrease, the sub-forces of the social factors must be adjusted to form a centripetal force.

在这一过程中,人的主体性发挥是社会有机体健康发展的灵魂。

Objective To investigate the relationship between the telomer ase activity and apoptosis in gastric cancer.

目的为了探讨胃癌组织中端粒酶与细胞凋亡的关系。