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This dissertation aims at finding anticancer and antibacterial polynuclear complexes targeting DNA with high activity and low toxicity. Sixteen compounds were synthesized, and characterized by means of X-ray single crystal diffraction, elemental analysis, molar conductivity and IR, and the influencing factors on structures of the compounds have been investigated. The actions of these compounds to DNA were also investigated by spectral, electrochemical and hydromechanical methods.
本论文以DNA为靶点,以寻找新结构类型的高效、低毒的抗癌、抗菌多核配合物为目标,从分子设计出发,共合成得到了16个化合物的单晶结构,对其进行了结构表征,探讨了结构影响因素,并研究了其超分子结构;采用紫外-可见吸收光谱法、荧光光谱法、电化学和粘度法,从分子水平上研究了所得配合物与DNA的相互作用;在细胞水平上,研究了草酰胺桥联双核配合物的抗菌和抗肿瘤活性。
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These data suggest that ACh may have a significant modulating effect on the proliferation of pituitary adenoma cells by means of paracrine or autocrine, and the effect is mediated by muscarinic receptor.
该结果提示, ACh可能以旁分泌或自分泌的方式作用于垂体前叶细胞,对垂体腺瘤细胞增殖分化有调控作用,而且是通过ACh M受体来实现的。
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Based on Stuart et al.'s electron density evolution equation, the electron density evolution process in fused silica film irradiated by short-pulse laser for τ∈[0.015] ps were studied by means of numerical method. The effects of initial electron density N and laser pulse width τ on laser threshold intensity I and damage threshold fluence. F were analyzed respectively.
基于STUART等人的电子密度演化方程,运用数值模拟方法,研究了脉宽为τ∈[0.01, 5]ps范围内单脉冲激光作用下熔融石英薄膜中电子密度演化过程;讨论了初始电子密度、激光脉冲宽度对阈值功率密度和阈值能量的影响;分析了初始电子密度、激光脉冲宽度对多光子离化及雪崩离化的影响。
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In this paper, the distribution, abundance and occurrence states of U in mantle xenoliths are studied by ~(235)U fission track method, and the movement of mantle fluids is revealed by means of U-tracer, which is a representative of incompatible elements in the mantle.
在此基础上进一步把铀作为不相容元素群的示踪剂,指示地幔流体在深部地幔岩中的活动轨迹。
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A new study idea that makes the occupant injury prevention research and CAD/CAE technology on an integrate mathematical model by means of feature theories and feature design technologies was brought, and it is maybe useful if we study automobile passive safety on a new view of point.The conclusions of this thesis included that what are the main factors of airbag-related injuries and the preventive measures, based on the research of the relationships between injury parameters, such as HIC, chest acceleration, neck force, neck moment, femur axial force etc, and impact speed, belt-use, occupant size (50th and 5th), sitting position and so on. The thesis evaluated whether the effectiveness of the airbag can be increased by making the airbag adaptive to the crash conditions, and points out that the size of the ventilation hole has the dominating influence on the performance of the airbag and is a key factor for intelligent airbag, multi-stage and lower-power inflator can cost effectively minimize the risk of injury to occupants from crashes. It is important for the researchers of intelligent airbag to keep the small size unbelted occupants in focus and it is necessary to study deeply the influence of airbag fold patterns and the extremity out-of-position situation. These topics are important in the study of occupant injury prevention and vehicle safety design.
论文研究得出产生气囊损伤的主要原因和防护措施;在研究汽车碰撞速度、安全带使用情况、乘员的体型5~(th和50~、乘员乘坐的位置等不同事故条件作用下,乘员的头部、颈部、胸部和腿部损伤参数变化规律的基础上,论文从能量因素出发,深入研究了安全气囊卸载能力、气体发生器产气能力和气囊折叠对乘员损伤参数的影响,指出起卸载作用的排气孔其截面积是智能型安全气囊最重要的控制参数之一,以及采用降能展开或二次充气气囊有助于提高汽车安全防护性等重要结论;论文在参数分析的基严内容提要2 础上得出的智能型安全气囊应以不佩戴安全带的5乘员作为主要防护目标进行研究、有必要深入研究气囊折叠形式和司机处于极端离位状况时对损伤参数的影响等结论,对深入进行汽车乘员碰撞损伤研究和汽车安全性设计都具有重要的理论和工程实际意义。
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Attached to the outside of the ladle are heavy trunnions by means of which it is lifted by an overhead crane .
铸桶外壁装有很重的耳轴,靠它可用天车把铸桶吊起来。
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The effect of pig splenic tissue extract on the suppressed thyroids by thyroxine was studied in rats by means of quantitative histology and ultrastructural observation.
通过定量组织学和超微结构观察研究了猪脾浸液对受甲状腺素抑制之大鼠甲状腺的作用。
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This paper reviewed the developments in 2-D numerical model of the water flow. By means of the latest observation data of the prototype, the detailed analysis was made on the major thalweg, section, island and bottomland, the erosion and deposition of the river bed and the scour hole near the dock and the law of the fluvial process was obtained. Based on the related references, the evolution trend of the channel after the Three Gorges was finished was predicted. The 2-D mathematical model of the water flow was set up and validated using the latest data. With the model, the flow and velocity of several cases were calculated. The stability computation of the bank at the typical section under difference conditions was carried out by adopting the world widely used Geo-Slope slope stability analysis program. Finally, the synthetical evaluation on the influence of the project on the flood level, velocity, river circumstances, bank protection and flood prevention was made and the conclusion that the construction of the dock had little effect on the flood discharge was obtained.
本文介绍了平面二维水流二维模型研究进展,对河道历史演变概述,通过最新原型观测资料对河道近期主泓线、断面、洲滩、河床冲淤、码头附近冲刷坑等进行详细分析,总结近期河道演变规律,并参考有关文献,对三峡建成后河道演变趋势进行预测;建立了平面二维水流模型,并根据最新资料对模型进行率定和验证,采用模型对几种工况组合进行壅水和流速计算;采用国际上广泛应用的Geo-Slope滑坡稳定分析程序对几种工况条件下工程断典型断面岸坡进行稳定性计算;最后总结工程建设对洪水位、流速、河势、堤防及防洪抢险等方面进行综合评价,得出码头建设对行洪影响较小的结论。
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It had been found that neuropeptide, which is mainly secreted by the ending of sensory nerve, could accelerate repairation by means of moderate the function of immune cells, switch on inflammation of nerve derived, promote the proliferation of repair cells.
过去研究发现,感觉神经末梢分泌的感觉神经肽类物质可以促进伤口愈合,其机制可能和启动神经源性炎症反应、调控免疫细胞功能、促使修复细胞增殖等有关。
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First, we introduce the linearly distributed stress tensors as the source and by means of two-dimensional finite-difference scheme to obtain the response of this source, then the point source response is generated by correcting both the wave forms and geometrical spreadings for the linear respons.
但在理论地震学,工程地震学和勘探地震学中横向不均匀介质中的波传播问题非常重要,此时使用有限差分法和有限元法等离散数值方法比较有效。鉴于目前计算工具的限制,三维模型的有限差分计算虽然在理论上是可行的,但很少能用于实际。
- 推荐网络例句
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Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.
Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。
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I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.
我来只是现在,'歼灭战perfuming自己与胡努特,那麼,他来到和SAT 。
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The shamrock is the symbol of Ireland and of St.
三叶草是爱尔兰和圣特里克节的标志同时它的寓意是带来幸运。3片心形叶子围绕着一根断茎,深绿色。