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RESULTSdiabetic rats showed typical symptoms involving elevated serum glucose and weight loss (2)The rats in DM+VaD group reacted slower and made more error numbers in Y-maze than the rats in VaD group did, with a prolonged total reacting time in a whole day.(3)More neurons with serious damages, such as edema, ischemia or pyknosis could be found in DM+VaD group than in VaD group. More disarrangement of cone neurons, obvious glia proliferation, and more neuron apoptosis were found in CA area of hippocampus. CONCLUSIONS (1)2-VO in STZ-induced diabetic rats succeeded in establishing VaD animal models.(2) The cognitive dysfunction induced by VaD rats had been deteriorated by diabetes mellitus.(3)Morphology evidences proved that diabetes mellitus aggravated brain damages induced by VaD.PART II Effect of diabetes mellitus on the cholinergic nervous systemin CA1 area of hippocampus of VaDOBJECTIVE To estimate the role of cholinergic nervous system in hippocampus during the process of cognitive dysfunction aggravated by diabetes mellitus in DM+VaD group. METHODS Observe the changes of ChAT protein by immunohistochemistry stain. Chose three rats randomly from each group at each pointat two week, four week, and eight week, then sepa

经腹腔注射链脲佐菌素诱导慢性实验性糖尿病，1周后永久性结扎双侧颈总动脉(2-VO)制作VaD模型记录术后2周、4周和8周各组大鼠的体重及血糖；应用Y-迷宫检测空间定向学第二军医大学博士论文中…丈摘…要1ia；一色恤~﹁染澎糕行HE染色观察组织病理学孪叱；胶质细胞原纤维酸性蛋白protellZ，Cf冰尸标记观察星形胶质细舱的激活情况、橄声软公点娜育票票众糯黑橄居端粗默孺篇筑价井袱第二部分糖尿病对血管性痴呆大鼠海马c心区胆碱能神经系统的影响探讨海马CAI区胆碱能神经系统在糖尿病加重确D一大鼠认知障碍中所实验动物及分组同第一部分，应用免疫组织化学染色方法现察海马CAI{介狱牛第晕军l袭拔常博粗{论义

After three years working experience, we has achieved many design projects successfully includes, the second stage landscape engineering design of Huankou Garden developed by Wuhan Real Estate Investment Group, the planning design and architecture design of Zonglian International Residential District developed by Wuhan Zonglian investment Co., Ltd, Phoenix Town developed by Wuhan Huayi Real Estate Co., ltd, Chutian Thermal Spring Hotel developed by Liannin Jingjiang Tourism company, Enshi Genevese Amorous District, the landscape design for new office building of Wuhuan Tech joint-stock co., ltd, landscape design for headquarter of Zhongye Southern Engineering Technical Co., Ltd, office and technical research building of Zhongtie 11 bureau, landscape design for the Xiangshan Minyuan developed by Yichang Hongxiang group Co., Ltd, planning for the Tingtao Guanhai district developed by Wuhan Hongyu Industry Co., Ltd and etc. all of the projects above got the good estimate form our clients.

公司成立三年以来，出色地完成了多项设计工作，其中包括武汉地产开发投资集团的汉口花园二期景观工程设计、武汉众联投资有限公司的众联国际小区的规划、建筑设计、武汉市华盈房地产有限公司的凤凰城、咸宁锦江旅业公司的楚天温泉假日大酒店、恩施日内瓦风情小区、五环科技股份有限公司新办公大楼景观设计、中冶南方工程技术有限公司总部景观设计、中铁十一局集团有限公司办公科研楼、宜昌弘洋集团公司的香山铭苑景观设计、武汉宏宇实业有限公司的听涛观海的规划、建筑与景观设计等项目，深受各开发商和业主的好评。

We introduced improved primary mixed glial culture and different-attachment method to isolate and purify the OPCs, the cells were proliferated in serum-free medium, flow cytometry and immunohischemistry methods were employed to estimate the purity of cultured OPCs. Their abilities of differentiation and expression of trophic factors were identified by RT-PCR and immunostaining. Several methods including TUNEL and MTT were adopted to estimate the protective effects of conditioned culture medium from oligodendrocyte lineage cells on the primary cultured cerebellar granule neurons. Intravitreal transplant of OPCs, combined with retrograde fluorescent labeling the superior colliculus and intraorbital optic nerve transection, were used to investigate the protective effects of OPCs on the axotomized RGCs in vivo. Intravitreal transplantof OPCs or NSCs on the newborn rats, and retinal transplant of OPCs on the young rats were performed, to observe the myelin formation in the retina at different stages after cellular transplantation. Optic nerve transection was carried out on some rats with myelinated retinae, to study the influence of myelination on the injuried RGCs.

为此，本研究采用改良的胶质细胞混合培养与差速贴壁方法获得大鼠OPCs，使用无血清培养基进行扩增、培养，用免疫组织化学和流式细胞技术对培养细胞的纯度进行鉴定，对少突胶质系细胞表达部分营养因子的情况进行检测；采用TUNEL、MTT等方法对少突胶质系细胞条件培养基对原代培养小脑颗粒神经元的保护作用进行检测；将OPCs移植入成年SD大鼠玻璃体内，利用上丘逆行荧光标记技术，观察眼内移植的OPCs对眶内视神经切断时的视网膜神经节细胞的保护作用及其持续时间；将OPCs或NSCs移植入新生和幼年SD大鼠玻璃体或视网膜内，观察不同时期视网膜内髓鞘形成与分布特点，分析髓鞘的超微结构，并观察眼内髓鞘形成对损伤神经节细胞的保护作用。

In practice, each sensor may have different observation dimension; that is to say, each sensor may make use of different model to observe the same target. In order to solve the above problem, by mapping among the state spaces, a nonequal dimension MAP estimate fusion algorithm between the output target estimate state and feedback is presented in this paper. Computer simulations show the effect of algorithm.

在实际中各传感器的观测信息维数不一致，也即各传感器可能采用不同的模型观测同一目标；为解决上述问题，通过建立状态映射，提出了输出目标估计状态之间维数不同情况下的带反馈极大验后估计融合方法，并通过计算机仿真验证了该算法的有效性。

Estimate of internal control plays a key role in modern audit. However, unscientifically, auditors mainly estimate internal control by their experiences.

内部控制的评价在现代审计中占有基础性地位，但是，以往对于内部控制系统的评价没有科学的依据，很大程度上依赖于审计人员的经验。

This paper studies environmental factors which influences Shanxi market of BYS Pharmaceutical Corporation applying theories and means of marketing and administration, makes qualitative and quantitative evaluation to exterior and interior environmental factors by using EFE and IFE matrix, and analyzes the actual place strategy. This thesis constructs generic mathematic model to estimate franchisers' integrated managerial abilities in order to choose the right middlemen; on how to evaluate dealers' performances, conceives mathematic model of franchisers' performance evaluation pole method to appraise their performances, and applies Fussy evaluation model to estimate the place pattern of pharmaceutical corporation, and makes embedded research into place motivation, conflict management and place improvement.

本文运用市场营销管理、管理学的理论和方法，研究了影响BYS制药企业山西市场营销的环境因素，运用EFE矩阵、IFE矩阵对外部环境、内部环境关键要素进行了定量定性评价；对营销渠道策略进行了分析研究，在对中间商的选择方面，论文构造了中间商的综合经营能力评价与选择的一般数学模型并运用其对中间商的综合经营能力进行了评价；论文对中间商绩效评价进行了探讨；运用Fussy评价模型对BYS制药企业营销渠道模式进行评价；并对渠道策略中的激励、冲突管理以及渠道改进等方面的内容进行了深入的研究。

He could estimate the measure of a tree very well by his eye; he could estimate the weight of a calf or a pig, like a dealer.

从一个装一蒲式耳或更多散乱铅笔的盒子里，他能飞快用手抓，而且每抓一次都是一打。

Along with big three arrivalses, I also will continuously favour, on the other hand, Be college of study department minister, again just right meet with an undergraduate course valuation, in spite of to who is all kind of pressure, besides is the teaching of the Ministry of Education valuation, that still is not my head up, school begins two month estimate favour dead, attended Normal University television station in Fukien on the other hand, participate television station of work, do film, return have what than the consume more of, again remove have a class of time, I estimate I possibility also have no when, luckily big three since need not learn English also need not learn athletics, easy is easy not a few, but face profession of thorough mental state more or less also have some touch, particularly is more and more of person all seem to have oneself of direction, but I seem to seem big two just just started grope for similar, we the class believe to will haven't a few violent girl and boy devotion to test to grind battalion, everyone also more and more went by different roads, believe big three big four ～ss~～ the person be more and more fickleness, ha ha.

随著大三的到来，我也将陆续忙起来，一方面，作为学院的学习部部长，又刚好碰上本科评估，不论对谁都是一种压力，何况是教育部的教学评估，那还不就是我的头上，开学两个月估计得忙死，另一方面，参加了福建师范大学电视台，要参与电视台的工作，做片子，还有什麼比这个更耗时的呢，再除去上课的时间，我估计我可能也没有什麼时间了，幸好大三既不用学英语也不用学体育，轻松是轻松了不少，但面对专业的深入心理多多少少也是有一点触动的，尤其是越来越多的人都似乎有了自己的方向，而我似乎好像大二才刚刚开始摸索一样，我们班相信会有不少强悍的女生和男生投入考研大军，大家也就越来越分道扬镳了，相信大三大四～~～人是越来越浮躁的，呵呵。

The effect of therapy was determined by clinical estimate combined with self-estimate of patients.

结果：所有患者用药一周后牙齿均有改善。48例中27人疗效满意，21人牙齿色泽改善。

The potential cost saving, in particular, has garnered much attention. One estimate, based on an outlay of $0.04 per stick of chewing gum, an estimate of 79,219 colectomies per year, and a mean cost of hospital stay of $1500 per day, suggests that if it were to reduce the length of hospital stay by 1 day, this intervention could result in savings of nearly $119 million annually in the United States Arch Surg .

尤其所能省下潜在的费用更是吸引人的目光；一项研究估计，根据每条口香糖0.04块美金的费用计算，再以每年进行79，219次大肠切除术的数字来看，每天住院的平均费用为1500块美金，显示如果可以减少一天的住院天数，该介入在美国每年将可以节省1亿1900万美金

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。