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Meanwhile, the immeasurable Amita surprises lies in: it can promote the development of secondary breast on the chest And abdomen without any side effects, And female breast hyperplasia breast disease And improve the role of the prevention of breast hyperplasia, is the international security Breast 100% of the functional bra.

同时,无量Amita的惊人之处还在于:它能促进乳房的二次发育,对胸腹部无任何副作用,并对女性乳腺增生等乳房疾病有预防和改善的作用乳腺增生,是国际上安全美胸100%的功能文胸。

Materials and Methods:236 pathology-confirmed breast lesions(155 malignanty,81 benignancy) and 221 disease-free contralateral breast tissues were examined using EPI-DWIb values=0,1000 s/mm~2TR/TE=8400ms/93.8ms; FOV=30×30cm;matrix=128×128;ASSET=2,slice thickness=4mm.DCE-MR imaging was also performed for accurate location of the lesion using VIBRANT sequence.The mean ADC values of malignant and benign lesions and the disease-flee contralateral breast tissues were calculated from the ADC map for each patient.One-way analysis of variance was applied to compare the mean ADCs of malignant lesions with benign lesions and disease-flee contralateral breast tissues.The threshold ADC value for malignant lesion was determined using a receiver operating characteristic(ROC curve analysis.Each lesion was classified into two major types:mass and non-mass lesion.The diagnostic performance of DWI was compared in breast mass and non-mass lesions.Results:155 malignant and 81 benign lesions were confirmed in 236 lesions.

材料与方法:搜集术前行乳腺MR检查并经穿刺或手术病理证实的236例乳腺病变,以对侧正常乳腺腺体作为正常对照,采用横轴位的平面回波-扩散加权成像序列,TR=8400ms,TE=93.8ms,层厚=4mm,激励次数=2:视野=30×30cm,矩阵=128×128,ASSET=2,b值=0和1000s/mm~2;参考动态增强图像准确定位,测量病变区和对侧正常乳腺腺体的ADC值,应用t检验比较良、恶性病变及正常腺体ADC值的差异,采用接收者工作特征曲线(receiver operating characteristic curve,ROC)确定良恶性病变的ADC界值;根据BI-RADS MRI将乳腺病变按照形态学表现分为肿块性病变和非肿块性病变两组,比较ADC值在肿块和非肿块性病变中定性诊断的效能。

After rectifying the family structure, and educational level of parents, the influencing factor of adaptability was formula mainly; intensity of reaction was breastfeeding duration for 4-6 months and breast milk mainly; rhythmicity was breastfeeding duration for 7-9 months and formula only; activity level was both breast milk an formula milk equally and breastfeeding duration for 7-9 months; quality of mood was formula only and duration of breastfeeding for 7-9 months; approach-withdrawal was breast milk mainly and both breast milk and formula milk equally; distractibility was formula milk mainly.

校正家庭结构、父母亲受教育水平等因素后,适应度的影响因素是主要喂奶粉;反应强度的影响因素是母乳喂养持续时间4~6个月和主要喂母乳;规律性的影响因素是母乳喂养持续时间7~9个月和只喂奶粉;活动水平的影响因素是母乳与奶粉等量和母乳喂养持续时间7~9个月;情绪本质的影响因素是只喂奶粉和母乳喂养持续时间7~9个月;趋避性的影响因素是主要喂母乳和母乳与奶粉等量;注意分散的影响因素是主要喂奶粉。

Methods: The expression of apoptosis and the positive expression of p53, bcl- 2 proteins were observed in 31 cases of breast cancer in situs, 20 breast dysplasia and 20 breast hyperplasia by using DNA nick end labeling technique and immunohistochemical staining . Eight normal breast tissues were used as control.

利用DNA缺口末端标记技术和免疫组织化学染色,原位观察31例乳腺癌,20例乳腺不典型增生和20例乳腺单纯性增生中细胞凋亡和p53、bcl-2蛋白的表达,以 8例正常乳腺组织作为对照。

Methods: By immunohistochemical methed, the expression of Bcl-2 and Bad gene were observed in eight cases with normal breast tissue, 19 breast hyperplasia and 20 breast atypical, as well as 48 with breast cancer in situs.

近年来,国内外有关在细胞凋亡调控中起重要作用的Bcl-2家族基因与乳腺癌关系的研究日益受到重视,部分学者认为乳腺增生病是乳腺组织从正常→单纯性增生→非典型增生→原2005年第32卷第10期位癌→浸润性癌的过程,是一个渐进的演变过程,非典型增生是癌变过程中必经的一个阶段。

The expressions of E-cadherin and α-catenin in specimens of 54 breast carcinomas and 21 normal breast tissues around tumor were measured by immunohistochemical method. Results In normal breast tissues, E-cadherin and α-catenin were expressed on cell membrance of ductal and acinic cells. No abnormal expressions were found in normal breast tissues. The abnormal expression rates of E-cadherin and α-catenin in breast cancer were 51.9% and 63.0% respectively.

结果 21例癌旁正常组织中,上皮钙黏蛋白和α-连接素均主要定位于腺泡或导管上皮细胞膜上,显示了细胞-细胞间交界和细胞轮廓,二者均表达正常;54例乳腺癌组织中上皮钙黏蛋白和α-连接素的异常表达率分别为51.9%和63.0%。

Methods Measurements were made in a group of 45 women volunteers aged from 22 to 45 years, who were satisfied with their breasts without any history of breast surgery. After the lateral arch of the breast as the reference value for breast size being chosen, breast-areola to nipple ratio was determined according to parameters measured as follows: weight, height, diameter of the breast, areola, and nipple, distances between the nipple and borders of the breast-superior, medial arch (to the medial end of the inframammary crease), lateral arch (to the lateral end of the inframammary crease), inferior arch (to the lowest point of the inframammary crease).

方法对45例22~45岁、对自己乳房满意且无乳房手术史的女性志愿者,分别测量体重、身高、乳头直径、乳晕直径、胸乳线(乳头至胸骨切迹连线距离)、乳房内侧半径(乳头至乳房下皱襞内侧止点连线距离)、乳房外侧半径(乳头至乳房下皱襞外侧止点连线距离)、乳房下半径(乳头至乳房下皱襞最低点连线距离)。

Thirty two point six percent (42/129) of menopausetransition women and 18.9%(60/318) of menopause women had breast structure changes,〓=9.26, P<0.01. The frequency of breast structure changes decreased with decreasing ofserum of 〓 level and increasing of age. Four (4/29, 13.8%) in HRT group had breaststructure changes, which disappeared after discontinuing HRT or reducing the dose of HRTin 3 subjects. Conclusions: Most of normal menstrual women and menopause transitionwomen experienced Mastalgia; Mastalgia occurred in 89.7% of subjects and lasted forabout 2 M. in the 1-year ccHRT; Image of breast ultrasound changed following menstrualcycle in normal menstrual women; Breast pain and breast structure change may be causedby higher 〓 and P level in luteal phase; The breast structure changes of HRT user weresimilar to that in normal women and were reversible.

大部分正常月经妇女和绝经过渡期妇女有周期性乳房胀疼,绝经后妇女应用17 β-雌二醇2mg加醋酸炔诺酮1mg连续联合治疗1年中大部分使用者有持续约两个月的乳房胀疼;乳腺体层厚度随体内雌孕激素水平的下降和年龄的增加而逐渐萎缩,绝经后妇女应用17 β-雌二醇2mg加醋酸炔诺酮1mg连续联合治疗1年后,对乳腺体层的厚度没有明显的影响;超声下乳腺结构改变主要受体内雌孕激素水平的影响,正常月经妇女中1/3的乳腺结构改变具有可逆性,绝经过渡期和绝经后妇女中有一半的乳腺结构改变的特征类似正常月经妇女具有可逆性的乳腺结构改变;绝经后妇女应用17 β-雌二醇2mg加醋酸炔诺酮1mg连续联合治疗1年后,少数使用者出现的乳腺结构改变可随药物剂量的调整或停药而恢复;对长期HRT使用者仍需加强乳腺的监测,长期HRT对乳腺的影响值得进一步研究。

To mensurate the expression of MDR1 of different breast cancer cells from human breast cancer primary cells and MCF-7 breast cancer cell line,and the kill effect of chemotherapy drug with different breast cancer cells in vitro,and the change of the proporation and the expression of MDR1 of breast cancer stem cells after chemotherapy.

测定人乳腺癌标本和MCF-7中不同细胞亚群的MDR1表达情况;并测定化疗药物在体外对人乳腺癌原代细胞和MCF-7中不同细胞亚群的杀伤作用,以及在化疗药物干预后,乳腺癌干细胞的含量和MDR1表达的变化情况。

Including clinical breast X-ray machine technology applications, digital breast X-ray machine performance testing and evaluation methods and projects, digital breast X-ray machine and traditional breast X-ray machine of distinction contrast, Finland Planmed high frequency of breast X-ray photography Clinical application, the new mammography X-ray machines and mammography in the diagnosis of the research topic.

包括乳腺X线机临床技术应用,数字乳腺X线机的性能测试方法及项目与评价,数字乳腺X线机与传统乳腺X线机的临床区别对比,芬兰Planmed型高频乳腺机X线摄影技术临床应用,新型钼靶X线机在乳腺摄影及诊断中的应用等研究课题。

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