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Methods seventy-two 15-week-old sd rats were divided into six groups,included control group and five ovariectomized model groups.the model groups were fed with different-dose lycopene[10,15,20 mg/] for 12weeks.then related indexes including length bone mineral density,bone mineral,serum estradiol,sertum alp and uterus index were analyzed.results compared with model group,three different dose groups and nilestriol[1.05mg/] group showed increased bone mineral density,bone mineral,serum estradiol and uterus index,but decreased serum alp (p.05).conclusion as a female sex hormone-like component,lycopene may ameliorate the bone quality and inhibit osteoporosis in ovariectomized rat.

将72只15周龄sd大鼠随机分为6组,空白组做假手术,其余5组做卵巢切除术,术后用药12周后处死,测定右侧股骨骨密度、骨矿含量、血清雌二醇、碱性磷酸酶含量及子宫湿重。结果番茄红素高[20mg/]、中[15mg/]、低剂量组[10mg/]、尼尔雌醇组[1.05mg/kg·bw]能对抗骨密度、骨矿含量、血清雌二醇的下降、血清碱性磷酸酶的升高,与模型组比较,p.05;番茄红素各剂量组、尼尔雌醇组能对抗子宫指数的减轻,与模型组比较,p.05。结论番茄红素可以改善骨质量,抑制大鼠去卵巢骨质疏松的发生。具有类似雌激素的效应。

Objective To compare the two diagnostic methods(bone marrow fragments smear and bone biop-sy)in hematology diseases.Methods Take bone marrow using routine aspiration and make bone marrow fragments smears;using trephine take a piece of bone marrow send it to the pathology department have a histodiagnosis.

目的 对造血系统疾病进行骨髓小粒拉片与切片两骨髓检查的方法进行比较方法常规髂后上嵴骨髓穿刺抽取骨髓液制成涂片;取骨髓小粒制成拉片;再用环钻法取骨髓组织制成切片并作相应的染色,结合临床进行分析。

Osteoporosis is a disease characterized by low bone mass and deterioration of microarchitectural bone tissue. The changes of bone tissue cause systemic bone pain, lumbago, arthrodynia, a increase in bone fragility and susceptibility to fractures, especially the danger of traumetic and spontaneons fracture. It severely demages the health and living quality of the aged.

骨质疏松症是一种以低骨量和骨组织显微结构退化为特征的疾病,骨组织的变化引起全身骨痛、腰背痛、关节痛等,并导致骨脆性增加,从而增加骨折危险性,易发生外伤性和自发性骨折,其严重危害老年人的身体健康和生活质量。

Clinical study indicated: the flavone of rhizome drynaria can promote collagen synthesis, improve bone transition, increase bone formation, delay bone resorption, furthermore, improve SOP patients' integer bone mass and proximate of femur bone strength, and prevent fracture of hip.Eventually, the level of living independence amended and the quality of life improved overall.

临床研究表明:骨碎补总黄酮具有促进老年性骨质疏松症骨胶原的合成,提高骨转换,增加骨形成,减缓骨吸收状况等作用,进而提高老年性骨质疏松的整体骨量,缓解腰背痛,提高股骨近端骨强度,预防髋部骨折,提升独立性生活水准,全面提高老年性骨质疏松症患者的生命质量。

Methods:The treatment of 18 cases with bone cysts was reviewed,which there were treated from January 2004 to February 2005. There were12 males and 6 females with an average age of 13 years?old. The bone cysts were located in the proximal humerus(n=9),proximal femur(n=4),proximal tibia(n=1),distal tibia(n=1),proximal ulna(n=1),distal ulna(n=1),and distal radius(n=1).Under fluoroscopy, two fine bone marrow biopsy needls pierced the bone cysts from the top and the bottom of the cyst respectively.The intracystic fluid was drawn out,the cyst cavity was irrigated and then the tissue engineering complexation of autologous red bone marrow and methylprednisolone with sodium hyaluronate was injected in percutaneously.

2004.1~2005.2月,对18例骨囊肿患者(男12例,女6例,平均年龄13岁;其中肱骨近端9例,股骨近端4例,胫骨近端1例、远端1例,尺骨近端1、远端1例,桡骨远端1例)以玻璃酸钠为载体抽取自体红骨髓加入甲基强的松龙,在X线透视下,将2根骨穿针经皮分别自囊腔顶部和底部刺入骨囊肿内,抽去囊液,冲洗囊腔后注入复合物。

Micronucleus test results exhibited that significant differences in micronuclear rates were determined between 0.4 mL bone cement and 0.4 mL microsphere-coated bone cement groups and negative control group, but no significant difference was detected among other groups. This revealed that this microsphere-coated bone cement leaching liquor did not show significant cell heredity toxic effects. Nevertheless, microsphere-coated bone cement in the high concentration and high dosage groups exhibited low toxic effects, mainly showing increased hemolysis rate and micronuclear rate. Thus, it was necessary to control the dosage and concentration of microsphere-coated bone cement.

微核实验结果显示除0.4 mL骨水泥组和0.4 mL微球骨水泥组的微核率与阴性对照组差异有显著性意义,其余各组差异无显著性意义,说明该微球骨水泥的浸提液无明显细胞遗传毒性作用,但是高浓度和高剂量组的微球骨水泥仍有较低的毒性作用,主要表现为溶血率和微核率的提高,因此在应用时要适当控制微球骨水泥的剂量和浓度。

BACKGROUND: Bone morphogenic protein 2 is one of the most important growth factors in the healing of bone fracture. The main function is to promote the undifferentiated mesenchymal cells and bone cells to recruitment and differentiate. It is the promoter of bone formation. The BMP-2 gene is an ideal gene that can be used to repair the bone.

背景:骨形成蛋白2是骨基质中最重要骨生长因子,主要生物学作用是促进未分化的间充质细胞和骨系细胞的募集和分化,是骨生成的启动因子,可以作为骨修复基因治疗的理想目的基因。

The BG100 series osteoporosis treatment meter use curative effect is remarkable, not can only improve the skeleton quality, the prevention bone fracture, to cut the bone fracture formation rate, the acceleration bone fracture cicatrization; May also use in treating the soft tissue damage, osteoarthropathy, the bone not to link, the bone fracture difficultly to heal and so on, and can promote young people's growth.

BG100系列骨质疏松治疗仪使用疗效显著,不但能改善骨骼质量、预防骨折、降低骨折发生率、加速骨折愈合;还可以用于治疗软组织损伤、骨关节病、骨不连、骨折难愈合等,并能促进青少年的生长发育。

The microstructure of the sintered bone was observed by scanning electron microscope and mercury porosimeter. Results showed that the sintered bone possess the three dimensional space structure composed of macropores and micropores. The diameter of macropore was 50-400 μm and the diameter of micropore was about 1 μm. Results suggest the sintered bone of β-TCP remains the porous structure of natural cancellous bone which is benefit to growing of new bone.

结果显示β-磷酸三钙煅烧骨具有大孔结构和微孔结构相结合的三维空间结构,大孔孔径为50~400 μm,微孔孔径为1 μm左右,提示β-磷酸三钙煅烧骨保留了天然松质骨的多孔状结构,有利于新生骨组织的长入。

[Objective]To compare the clinical results of different bone graft in the posterior route spinal fusion of adolescent idiopathic scoliosis.[Method]A retrospective study was made in 71 case of adolescent idiopathic scoliosis,who were operated on with posterior instrumentation of screw-rod fixation system from 2000 to 2005.All of the patients were divided into three groups,autologous bone graft in 21 cases,allogous bone graft in 23 cases, autologous bone mixed allogous bone graft in 27 cases. The fusion rate, the Cobb's angle loss rate of incidence and pseudoarthrosis were compared among the three groups at 3,9,15,36 months follow-up.

[目的]通过不同植骨在青少年特发性脊柱侧凸后路矫形植骨融合术中的应用比较,探讨其临床应用效果[方法]回顾性分析2000年~2005年行后路钉-棒系统矫形手术的71例青少年特发性脊柱侧凸患者,其中自体骨移植21例,同异体骨移植23例,自体骨混合同种异体骨移植27例,比较随访第3、9、15、36 月的融合率、Cobb's角丢失率及假关节发生率。

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