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Craniomaxillofacial surgery or accidental injury frequently results in large bony defects requires the bone grafts to enhance the bone healing. Synthetic bone substitutes such as hydroxyapatite, tricalcium phosphate and calcium sulfate have shortcomings in the sense that they have prolonged working and setting time, poor strain, shear strength and not easily shapeable. Therefore, the purpose of this study is to develop a novel, convenient and easily shapeable bone graft that is composed of poly-lactic acid and polycaprolactone as the matrix and calcium sulfate as the filler.

口腔及颅颜外科手术或意外伤害时,倘若造成大范围之骨缺损,常因愈合不易而需要进行骨移植术加速骨的愈合,目前虽有氢氧磷灰石,磷酸钙与硫酸钙合成骨替代物等选择,但这些产品操作及固化时间长、不易塑形、抗张力与抗剪切力较低,而造成手术时间变长,因此本研究目的在研发一种新型且操作便利,可快速塑形,符合组织工程原理,应用於骨缺损的骨?

Craniomaxillofacial surgery or accidental injury frequently results in large bony defects requires the bone grafts to enhance the bone healing. Synthetic bone substitutes such as hydroxyapatite, tricalcium phosphate and calcium sulfate have shortcomings in the sense that they have prolonged working and setting time, poor strain, shear strength and not easily shapeable. Therefore, the purpose of this study is to develop a novel, convenient and easily shapeable bone graft that is composed of poly-lactic acid and polycaprolactone as the matrix and calcium sulfate as the filler.

中文摘要口腔及颅颜外科手术或意外伤害时,倘若造成大范围之骨缺损,常因愈合不易而需要进行骨移植术加速骨的愈合,目前虽有氢氧磷灰石,磷酸钙与硫酸钙合成骨替代物等选择,但这些产品操作及固化时间长、不易塑形、抗张力与抗剪切力较低,而造成手术时间变长,因此本研究目的在研发一种新型且操作便利,可快速塑形,符合组织工程原理,应用於骨缺损的骨?

Methods On the basis of animal model of cleft palate bone defects in rabbits, composite materials (bBMP-albumin-bFGF) and single albumin were first used to repair the cleft palate bone defect respectively in rabbits, involving new bone formation and repairing bone defect by their induction effects.

建立家兔腭骨缺损模型,将固化的bBMP-白蛋白-bFGF复合材料植入骨缺损区,通过其骨诱导作用,诱导新骨生成,修复骨缺损。

Two days after bone marrow MSCs compounded to nano-CS/COL scaffold, bone marrow MSCs presented globular shape and were scattered; Four days later, bone marrow MSCs presented shuttle shape, extended and anchored on the surface of nano-CS/COL by pseudopods; Eight days later, bone marrow MSCs proliferated and fused each other, and they secreted a lot of extracellular matrix, then which covered most material particles.

骨髓基质干细胞复合到纳米壳聚糖-胶原纤维支架后2 d,细胞呈球形散在分布;4 d 后细胞呈梭形,延展爬行且有伪足与材料表面锚靠;8 d 时细胞增殖,相互间融合,并有大量的细胞外基质分泌,大部分材料颗粒被覆盖。

This function does, fresh cow bone, the pig big bone, sheep cow , the chicken bone, the pigskin, the cowhide, the sheepskin, the entire fish stave and so on, is the poultry bone intensive processing best choice, is also in the middle of meat grinder's war-god.

该机能破碎干、鲜牛大骨、猪大骨、羊骨、鸡骨、猪皮、牛皮、羊皮、整鱼等,是禽畜骨深加工的最佳选择,也是绞肉机当中的战神。

Bone remodeling appears to be governed by a feedback system in which the bone cells sense the state of strain in the bone matrix around them and either add or remove bone as needed to maintain the strain within normal limits.

骨骼的重新塑造由一套反馈系统管理,在该系统中,骨骼细胞感觉到它周围的骨骼基质的拉紧状况,按照需要要么增加要么移动骨骼来在标准范围中维持这个状况。

Measuring bone speed of sound was developed. This method measure bone density, and other bone properties such as cortical thickness, elasticity and micro-architecture, thus providing a more complete picture of bone strength.

可以用来测量骨密度和其他骨指标,比如:皮层厚度,柔韧度和显微结构,因此给我们提供了一张更完整的关于骨强度的照片。

In school children, tibial bone strength of obese group and overweight group, normal weight group was in the increasing order; the descending risk of bone strength in obese and overweight group was 9.73 and 2.54 times of normal group respectively. Radialis bone strength of obese group was worse than overweight group and normal weight group, while the bone strength of overweight group and normal weight group was not different.

学龄儿童正常、超重、肥胖组的胫骨骨强度依次下降,肥胖、超重组胫骨骨强度下降风险是正常组的9.73和 2.54倍;学龄肥胖组桡骨骨强度低于正常组,超重组与正常组无差别。

Human skull by two parietal bone, two pieces of frontal bone, two temporal bone and occipital bone and so on.

人的头颅是由两块顶骨、两块额骨、两块颞骨及枕骨等组成。

Fontanelle at birth, there are two major: a skull that static in the front of heads from both sides of the parietal bone and frontal bone-phase before the corner formed at birth oblique diameter of 2.5 cm, usually in 1 ~ 1. 5-year-old closed; fontanelle after another said, by the parietal bone and occipital bone and the composition of the transition, in the back of the head, the general was born on a small or closed, the latest in 2 to 4 months after closing.

囟门在出生时主要有两个:一个称静囟,在头顶前部,由两侧顶骨前上角与额骨相接而组成,出生时斜径为2.5厘米,一般在1~1.5岁闭合;另一个称后囟,由顶骨和枕骨交接而组成,在头顶后部,一般出生时就很小或已闭合,最晚在2~4个月时闭合。

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