查询词典 bone

The biomechanical tests showed that two kinds of artificial bones had not significant difference on compressive strength and Young\'s modulus(P＞0.05),while the flexural strength of nano-nacre artificial bone was less than the control group(P＜0.05).3.The results of CCK-8 showed that the difference were not significant in each group,the proliferation of osteoblast reached the peak at the 5th day;7 days after being co-cultured,the total protein content of study group was higher than control group and blank group(P＜0.05),while the difference between control group and blank group was not significantP＞0.05The difference of alkaline phosphatase activities among three groups was not significant(P＞0.05The SEM view showed that osteoblast attached and grew well in two kinds of artificial bone.4.X-ray photography showed that two kinds of powder started to degrade in 2 weeks;this phenomenon became more appear in 4 weeks,nano-nacre powder degraded faster than micron-nacre powder,while the hole shadow was easy to be found;in 8 weeks,all the femoral holes recovered and returned to normal bone mineral density in all groups.Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone grew fastest around the bone defect area in study group,while most slowly in blank groupP＜0.05 SEM(scanning electron microscope observation showed that nano-nacre powder degraded more quickly.The same result can be found through the demineralized sections morphometric analysis,and both of the composite artificial bones made from those two kinds of nacre powder had the good connection with the adjacent tissue in rats body without apparent inflammatory response.5.X-ray photography showed that rabbit\'s bone defects healed faster in study group since NNAB implanted than in control group since MNAB implanted.At 24 weeks after operation,bone density in radial defects had nearly accessed to the normal area,while lower in control group,and turned up nonunion in blank group;The checking of BMD showed that results in study group were higher than those in control group at 8,16 and 24 week(P＜0.05), and the difference between the BMD values in study group at 24 week and those in blank group was not significant(P＞0.05).The gross specimens showed satisfactory histocompatibility both in study group and in control group,with bone tissue growing from two sides into the center of implanted materials; Normal slices in HE stain and hard tissue grinding slices in Stevenel\'s blue/Van Geison\'s picro-fuchsin stain showed that the bone growth tendency was better in study group than that in control group,and the medullary cavity had been penetrated to the implanted materials in study group at 24 week;Analysis of tetracycline fluorescent double marks in the hard tissue grinding slices indicated that new bone in both groups grew fastest 8 weeks after surgery,while slow down at 16 week.

纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨分别与成骨细胞共培养后，其各时间点CCK-8法检测值与空白对照无显著差异(P＞0.05)，成骨细胞均在第5天达到增殖高峰期；培养7天后，实验组细胞蛋白含量高于对照组及空白组(P＜0.05)，后两者之间则无显著差异P＞0.05碱性磷酸酶活性在三组间均无显著差异(P＞0.05电镜下可见成骨细胞在两种人工骨上都有良好生长贴附能力。4.X-ray显示两种粉体在大鼠股骨骨洞植入第2周时都开始出现了降解，第4周时更为明显，纳米珍珠层粉较之微米珍珠层粉降解更快，而空白对照组骨洞阴影仍可见，至8周时，则所有组骨洞均己闭合修复，X-ray下已不可见原钻孔痕迹，恢复正常骨质密度；硬组织磨片四环素荧光双标记结果显示纳米珍珠层粉植入组较其余两组在骨缺损区周围新骨生长速度更快，空白组速度最慢P＜0.05电镜观察及常规脱钙切片亦可见到纳米粉体降解较快；由以上两种原材料制得的纳米珍珠层/消旋聚乳酸复合人工骨与微米珍珠层/消旋聚乳酸复合人工骨在大鼠体内均与周围组织结合良好，无明显炎症反应。5.X-ray显示纳米珍珠层/消旋聚乳酸复合人工骨植入兔桡骨缺损区后其骨愈合速度较对照组微米珍珠层/消旋聚乳酸复合人工骨植入的快，至植入术后24周，实验组骨缺损区接近正常骨密度，对照组骨缺损区密度较低，空白组则呈现骨不连状态；骨密度测量结果显示术后8周、16周、24周实验组的骨密度值高于对照组(P＜0.05，24周实验组的骨密度值与术前所测得的正常值无显著性差异P＞0.05动物取材大体所见均显示组织相容性良好，骨组织逐渐由植入材料两端向中央生长；常规切片HE染色及硬组织磨片Stevenel\'s blue/Van Geison\'s picro-fuchsin联合染色均可见实验组骨缺损区长势优于对照组，至术后24周，实验组骨髓腔与材料已呈相交通状；硬组织磨片荧光显微镜下观察，两组材料在术后8周处于骨生长最快速时期，16周时速度开始减慢，术后4、8、16周时实验组的新骨生长速度均较对照组的快

New bone formation was observed to be increasing significamly in both DCN bone cements and DC bone cements with the passage of time. By the end of 24 weeks, new bone had bridged the gap between the proximal and distal fragments in DCN bone cements and DC bone cements. By histomorphological detection in DCN bone cements, Abundant of chondral and new bone islands were seen at the site of defects 4 weeks after the operation and a number of new bones formed and enlarged by both enchondral ossification and appositional formation by the 8th weeks.

研究发现，DCN骨水泥植入4周大量间充质细胞分化，在材料与骨端之间出现一层软骨细胞，软骨细胞继续增生并向编织骨分化；8周材料降解的同时，小梁骨出现；12周新骨长入材料并已经基本替代完成，形成初步骨性连接；24周骨缺损完成骨性连接，新骨进行结构改建，材料内部形态结构明显变化。

The periostea of both experimental and control side of the mandibular ramus were taken and prepared, 2 of each 5 rabbits in a group were prepared for HE stain detection and 3 for proliferating cell nuclear antigen immunohistochemical detection.Results:1, The newly formed bone was detected on the lateral aspect of mandibular ramus after periosteal distraction. The bone was shaped like a hill. It looked very low and was full of holes at postoperative day 28. With the time of consolidation period lengthened, the newly formed bone matured gradually. X-ray examination showed the new bone shaped like a hill. The average values of new bone height at postoperative days 28,35,42 and 56 were 1.86 + 0.15mm, 2.29 + 0.29mm,3.19 + 0.13mm and 4.70 + 0.45mm. Histological examination of both HE stain and picricacid-fuchsin stain showed the increase in the number of osteoblasts and the change in the orientation of collagen fibers and bone trabecula. There were no significant differences between newly formed bone and original bone on the lateral aspect of mandibular ramus at postoperative day 56 histologically.2 Compared with the control side, the distracted periostea proliferated obviously under the microscope, and the number of periostealcells increased with satiation of cellular nuclear per unit area. The images of PCNA immunohistochemical stain of periosteum showed that the experimental periosteum proliferated obviously after distraction compared with the control side.

结果：骨膜牵张成骨的实验研究南京医科大学硕{学位论文l、骨膜牵张后，可见下领升支外侧的骨皮质上有新骨形成，新骨呈山峰状凸起，术后第28天的新生骨较低平，多孔隙，随着固定时间的延长，新骨逐渐成熟；下领升支前后向切线位X线投照显示新骨呈山峰样隆起；经测量，术后第28、35、42和56天组平均新生骨厚度分别为x.86士0.15mm、2.29士0.29mm、3.19士0.13mm和4.70 土0.45mm；脱钙骨组织的HE染色和不脱钙骨组织的苦味酸一品红染色的组织学观察均显示了新生骨在成骨细胞数量上的增长，以及胶原纤维和骨小梁排列方向上的变化，术后第56天的新生骨在组织学上与原升支骨组织已无明显区别。2、HE染色显示，与对照组相比较，实验侧骨膜增生明显，细胞间排列紧密，单位面积内骨膜细胞数增多，细胞核饱满；骨膜PCNA 免疫组化染色显示，与对照侧相比较，实验侧骨膜在牵张后出现了明显的增生迹象，PCNA阳性细胞分布紧密，单位面积内阳性细胞数较对照组多，靠近骨表面的骨膜中的阳性细胞数更多而且分布更为紧密。

RESULTS:① Gross observation: At 2 weeks, there were no differences between the two groups, and the materials were connected to bone bed with fibrous tissues. At 4 and 8 weeks, there was more new callus in biologic active bone group than in biologic bone group. At 12 weeks, some bionic biphasic ceramic-like biologic active bone were absorbed and new bone regenerated in biologic active bone group, being similar to appearance of host bone, but there were few callus in biologic bone group.

结果：①大体观察：生物活性骨组和生物骨组术后2周时无明显差别，材料与骨床间为纤维组织连接。4周及8周可见生物活性骨组断端周围新生骨痂较多，将材料包绕，12周时可见材料部分吸收，新生骨长入，修复段塑型较好，基本接近宿主骨外形。12周时，生物骨组仅在骨折端有少量骨痂连接。

Based on the traditional products of bone paste, bone oil, bone meal, and so on, the application of modern processing technology was carried on deep-processing of the animals' bone to meet the market demand for the development of bone extract, bone peptide and the like high value-added products, so improved the bone nutrition and economic value greatly.

应用现代工艺技术对畜禽骨进行深度加工，可在传统骨泥、骨油、骨粉等产品基础上，开发出适应市场发展需求的骨素、骨肽类高附加值产品，从而大大提高骨的营养及经济利用价值。

METHODS: From January 2000 to May 2002, 52 cases with various types of bone defect were treated with tissue engineered bone, which was constructed in vitro by allogeneous osteoblasts from periosteum 1 x 10(6/ml with bio-derived bone scaffold following 3 to 7 days co-culture. Among them, there were 7 cases of bone cyst, 22 cases of non-union or malunion of old fracture, 15 cases of fresh comminuted fracture of bone defect, 4 cases of spinal fracture and posterior route spinal fusion, 3 cases of bone implant of alveolar bone, 1 case of fusion of tarsotarsal joint.

2000年1月～ 2002年1月，用同种异体骨膜来源的成骨细胞 1×106 / ml与生物衍生骨支架材料构建的组织工程骨，经体外培养 3～ 7天后，植入修复52例各种类型的骨缺损，其中骨囊性病变7例，陈旧性骨折不愈合或畸形愈合 2 2例，新鲜粉碎性骨折伴骨缺损 15例，脊柱骨折后路植骨融合术4例，牙槽骨植骨 3例，足跗中关节植骨融合 1例。

The fundamental imaging features of osteosarcoma were showed bone destruction, periosteal reaction, neoplastic bone and soft-tissue mass. Among 49 cases examined by radiography, osteoblastic pattern sarcoma was found in 19 cases, osteolytic pattern sarcoma was found in 13 cases and mixed pattern sarcoma was found in 17 cases. The detection rates of bone destruction, periosteal reaction, soft-tissue mass, neoplastic bone and Codman triangle by radiography were respectively 61.2%, 95.9%, 71.4%, 73.5%and 27.7%. All 10 cases with CT scan were showed bone destruction, soft - tissue mass and neoplastic bone. The detection rates of periosteal reaction,憇ieve sign挶 and Codman triangle with CT scan were respectively 90%, 90% and 11%. The tiny neoplastic bone and"sieve sign"were showed sensitively by CT, but Codman triangle was showed by radiography superior to CT.32 cases with MRI scan presented the normal marrow was replaced by the tumor, which was showed low to intermediate signal intensity on T1-weighted images and promiscuity signal intensity on T2-weighted images. 7 cases presented hemorrhage and 24 cases presented necrosis.

骨肉瘤基本影像表现为骨质破坏、骨膜反应、瘤骨和软组织肿块。49例X线表现为成骨型19例，溶骨型13例，混合型17例；X线对骨质破坏、骨膜反应、软组织肿块、瘤骨和Codman三角的检出率分别为61.2%、95.9%、71.4%、73.5%和27.7%；10例CT表现均可见骨质破坏、软组织肿块及瘤骨，CT对骨膜反应、筛孔征和Codman三角的检出率为90%、90%和11%；CT对显示细小肿瘤骨和筛孔征最敏感，但对Codman三角的显示不如X线平片；32例MRI表现为骨髓腔内正常的骨髓高信号被肿瘤信号所取代，T1WI呈低～等信号，T2WI呈混杂信号，7例合并出血，24例中央坏死囊变，32例增强扫描均呈不均匀强化及瘤周可见水肿区。

To evaluate the effect of autolyzed antigen-extrac ted allogenic bone graft combined with autogenic red bone marrow o n bone defects, 58 cases with benign bone tumor(66 long bones) were treated with curettage operation, and the post-curettage bone defects were filled with the complex of "AAA" bone combined with autogenic red bone marrow.

目的：探讨同种异体低抗原脱钙骨与自体红骨髓复合移植对良性肿瘤刮除后骨缺损修复能力的影响。

Breast cancer commonly metastasizes to bones, producing both osteolytic and osteoblastic deposits. Different markers for quantitative determination of bone turnover have been developed to evaluate bone metastases of breast cancer. The urinary deoxypyridionline, a crosslink product of collagen molecules found in bone and excreted in urine during bone degradation, and bone specific alkaline phosphatase, an isoenzyme localized in the membrane of osteoblasts and released in circulation during bone formation, were recently described as a group of markers of bone turnover in metastatic cancer.

乳癌患者常见骨髓转移造成溶骨性及成骨性沈积物，而利用不同标记来定量骨质转换形态，可以评估乳癌骨骼转移的变化，而尿液中Deoxypyridinoline是骨质内胶原分子在骨骼破坏分解时至尿中的产物，骨特殊碱性磷酸酵素是一种同形酵素，位於成骨细胞的外膜且在骨骼形成时释放至血液中，利用此两种生化标记，可以来预测乳癌转移至骨骼的转换情形。

In the second part of this thesis. The biological process of porons HA/bBMP composite repairing experimental defect in the dog femora and monkey mandibular were investigated by the qualitative and quantitative methods. The results showed that not only were the speed and time of new bone ingrowing into the bBMP/HA composite much quicker and earlier than that of implants of HA alone, but also the quantity of new bone ingrowth into bBMP/HA composite was much higher than that of HA alone. The bone ingrowth of bBMP/HA composite at higher rate within 3 weeks. In this study, bBMP/HA promoted more active new bone formation in bone marrow tissue than did HA alone. This reveals that BMP, brought into the bone marrow with HA as a carrier, accelerates osteogenesis or osteoinduction, providing sime bone marrow cells with more differentiative potential.

论文第二部分应用定性和定量的方法，较全面地研究了HA/bBMP复合人工骨在修复狗股骨和猴下颌骨实验性缺损中的生物学过程，研究发现，新骨组织长入HA/bBMP复合人工骨的时间和速度都较单纯HA早和快，而且新骨形成量也明显高于单纯HA，HA/bBMP在挂入后早期(3周)的成骨最为活跃，自体骨髓组织可为BMP提供敏感的靶细胞，增强BMP的骨诱导效果和HA/bBMP复合人工骨的骨修复能力。

Objective To study the effect of chitosan in the prevention of fibrous scar formation in the epidural space after laminectomy.

目的 观察选择性脊神经后根切除术椎板切除后硬膜外几种防瘢痕粘连物质的作用并探讨其机制。

On his way to the lift, he looked back to us or was it me his eyes pointing?

当他要进电梯时，他回头看我们（或者说是我，他的眼光？