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Measuring ADDL binding with and without oleocanthal, they discovered that small amounts of oleocanthal effectively reduced binding of ADDLs to hippocampal synapses.

研究人员发现少量的橄榄油辣素就可以有效地降低 ADDLs 与海马回上的突触结合。

The dose-dependent experiment revealed that Id1 antagonised E47 and Ets1 mediated transcriptional activation in a dose-dependent manner. With pGL3-870 as a template, site-directed mutagenesis of E-box and / or ETS-binding site was introduced into p16 promoter. E47 could not activate the transcription of p16 promoter with E-boxes mutated, and Ets1 could not activate the transcription of p16 promoter with EBS mutated. The synergy effect between E47 and Ets1 would occur only if the E-boxes and EBS were present. These facts demonstrated that E47 and Ets1 proteins were not recruited to the promoter by binding to other cis-elements or through interaction with other protein factors, however, they bound to DNA directly through respective consensus sequences in p16 promoter.

以pGL3-870为模板，构建了E-box或/和EBS点突变的p16启动子报告基因载体，将野生型和突变型的报告载体分别与pI-E47、pI-Etsl以及pI-E47+pI-Ets1共转染，发现E47和Ets1所诱导的转录激活作用依赖于启动子DNA上存在的各自的特异结合序列，二者的协同作用也只有当两个结合位点都存在时才会发生，说明E47和Ets1不是与其它作用元件或其它蛋白质因子相作用而被招募到该启动子的，它们是通过启动子上各自的特异结合位点与DNA直接结合的。

This is with a nail-binding form or stitch binding, somechildren, coupled with the soft-cover of charging method, such as phone books, novels, magazines, etc.

是用铁钉钉装形式或缝线钉装，在外面再加上软封面之装钉法，如电话簿、小说、杂志等。

The stimulatory effect on the MMP-13 promoter was partially inhibited by mutation of the osteoblast-specific element 2 (OSE-2) binding site ⑸ Core binding factor-1 (Cbfa-1) expression peaked at 7 days ⑹ of differentiation, and was phosphorylated by PKG in itro.

免疫组织学检查揭示在17天大的embryo iNOS缺乏的老鼠MMP-13和Cfba-1表达水平均降低。Cfba-1 mRNA的沉默阻滞MMP-13的表达，不影响内源性的NO产生，肯定了他在MC3T3-E1细胞中NO诱导的MMP-13的表达中的作用。

Also equipped with a variety of perfect binding equipment, and fully binding on the customer to meet the different needs.

还配备了各种完善的装订设备，充分满足了客户对装订的不同需求。

Binding: Magazines typically use saddle-stitching or perfect binding depending on the number of pages.

Binding ：杂志根据页的数量典型地使用备鞍缝或无线胶订。

One-shot binding: Perfect binding with one application of hot-melt glue only.

一次胶胶装：用热熔胶涂书脊一次的胶装。

Both Mg and Al has no bonding with perfect sheet due to negative binding energy at all symmetric positions, however, the introduction of a Stone-Wales defect increased the binding energy at all adsorption sites to negative values.

Mg和Al不能稳定吸附在完整的石墨烯片上，但是引入SW缺陷降低结合能，使其能够稳定吸附在石墨烯片上。

In this chapter,on the base of discussingcomprehensively the three subjects of the Adversary Principle,andcombining with the practice of the reform of the civil trial style,thewriter holds that the non-binding Adversary Principle that is beingpracticed for the time being in our country is not the Adversary Principleof its essence,and it should be changed to be the binding standard to boththe court and the parties.On this,the writer have given the followingdefinite suggestions:First,the parties' claim acts should be controlledunder the law,and cannot be exercised for the objectives of delaying theproceedings or raising the action cost,otherwise will suffer losing hisright,or will be punished economically;Second,in order to reflectthe fairness of the action,and prevent the delay of the process,in thecivil procedure field of our country the timely evidence producism shouldbe carried out and implemented,and the evidence-production deadlinesystem should also be set up.Furthermore,to the parties that produceevidence out of time,hewill be deprived of attack and defense,orwill be given certain economic sanctions; Third,scientific admissionsystem should be set up,and to the admission withdrawal or statementscontradictory to the admission,should give legal restrictions orprohibitions.

本章中，作者在全面论述辩论原则三大命题的基础上，结合我国民事审判方式改革的实践，认为我国目前推行的非约束性辩论原则并非本质意义上的辩论原则，应将其转变为对法院和当事人的约束性规范原则，并在此基础上提出了如下具体建议：第一，当事人主张行为应受法律控制，不得以拖延诉讼、增加诉讼成本等为目的予以实施，否则将遭受失权效或经济上的诉讼制裁；第二，为体现诉讼公平，防止诉讼迟延，在我国民事诉讼领域应当推行和贯彻证据的适时提出主义，设置具有法律后果的举证时效制度，并对当事人违反举证时效制度的提供证据行为采取或取消其攻击防御方法，或课以其一定经济性制裁的惩罚措施；第三，设定科学的自认制度，对撤销自认或与自认相抵触的陈述应给予法律上的限制或禁止。

Edition binding: Conventional casebound binding produced under a production line.

精装：由整条生产线完成的常规性硬皮装订。

You can snipe the second and third union leaders from this position.

您可以鹬第二和第三工会领袖从这一立场出发。

Aiming at the currently shortage of XML streams quality detecting, this paper proposes a new forecasting method of XML streams quality by least squares support vector machines, which is used the method of XML keys' vector matrix as windows, and vector product wavelet transform to multilevel decompose and refactor the XML streams series, that can fulfill real-time checking demand of XML quality, and ensure constraint, consist- ency and integrality. For even more adapting net load, it proposes a control strategy by weight and adaptive adjustment to ensure XML streams quality.

针对当前XML数据流质量检测存在的不足，提出构建XML键的矢量矩阵作为窗口，利用矢量积小波变换多级分解与重构XML数据流，再结合最小二乘支持向量机对XML数据流质量进行预测的一种方法，满足XML数据流质量重构时实时检测的要求，保证XML数据的约束性、一致性与完整性；为了更好的适应网络负载，采取加权与自适应窗口调整等调度策略充分保证XML数据流的质量检测。