查询词典 binding edge

A series of study methods which can not research in this field begin to exert important affection. On the basis of the previous research, the following major innovative work was carried out in this dissertation.(1) Several methods including fluorescence spectra, CD and FT-IR specta methods were used to study the interaction of isoquinoline alkaloid、isoflavones and Rhein with serum albumin, and the results from every method was in good agreement;(2) The binding constants、the numbers of binding site、the binding region and the interaction force involving in the interaction of drugs and serum albumin were confirmed by Scatchard equation and Vant Hoff equation.

基于研究生物大分子与小分子相互作用具有极其重要的意义，本博士论文在前人工作的基础上，主要进行了以下几方面的创新性研究：(1)利用荧光光谱法、圆二色谱法、红外光谱法以及分子模拟等多种方法相结合研究了异喹啉类生物碱，异黄酮类化合物以及大黄酸与人血清白蛋白的相互作用，获得了准确一致的信息；(2)根据Scatchard方程和Vant Hoff方程详细研究计算了异喹啉类生物碱以及大黄酸与蛋白质结合机理包括结合常数、结合位点数、结合区域、结合力。

It is generally accepted that there are three kinds of binding modes for small molecules to DNA, which refer to intercalative binding, groove binding and electrostatic force.

对于小分子来说，分子的哪一部分插入DNA是很重要的因为它不仅有利于探索和开发新的核酸探针，而且有助于从分子水平上了解抗癌药物的作用机理，并为设计合成具有应用前景的高效的疾病诊断和化疗药物提供有用的信息。

Seam binding is the most fundamental form seam binding but the need to neaten the raw edges of the binding makes its use more difficult.

止口条是这道工序最基本的形式。斜滚边是滚边发展而来的，但需要修剪滚边的毛边，这使得它做起来比较难。

The results indicated that the extraction rate of mineral from pollen in 70℃ water was the highest. the extraction rates of four mineral: Fe, Zn, Cu and Mn were 6. 931％, 52. 786％, 44. 443％ and 46. 549％ respectively. Second speciation presented in the form of exchangeable and nonexchangeable speciations, organic and inorganic speciations at the same time. The contents of both Fe and Mn in nonexchangeable speciation were more than 50％, most contents of Fe、 Zn、Cu、Mn were inorganic speciation. Among the four elements, the content of protein binding speciation of Fe was the highest: 47. 305％. The average mineral contents of soluble carbohydrate and grease binding speciation were less than protein binding speciation.

结果表明：70℃水浸泡花粉，矿物质浸出率最高，Fe、Zn、Cu、Mn四种元素总提取率分别为6.93l％、52.786％、44.443％和46.549％；次级形态以稳定态与不稳定态、有机态与无机态等多种形态共存，其中Fe、Mn元素不稳定态含量均大于50％，Cu、Zn、Mn、Fe元素大部分以无机态形式存在；四元素中Fe元素蛋白质结合态最高，达47.305％，可溶性糖类结合态及脂肪结合态平均含量比蛋白质结合态平均含量少。

The invention discloses an elastic sectionalization ring address binding method in the network transmission technological domain, which is characterized by the following: realizing the binding of RRP ring node MAC address and IP address through ATD frame in the extended RPR protocol; without adding extra system resource consumption; converging rapidly for topology after the RPR looped network occurs switching; providing address binding information for over three layered report to transfer and utilize.

本发明涉及传输网络技术，公开了一种弹性分组环地址绑定方法，使得在不增加额外系统资源消耗的情况下实现RRP环节点MAC地址和IP地址的绑定，并且在RPR环网发生倒换后，拓扑可快速收敛。本发明中，通过扩展RPR协议中的ATD帧，在广播ATD帧的同时携带MAC地址和IP地址绑定的信息，实现所有RPR环节点的MAC地址和IP地址的绑定，该地址绑定信息可供三层以上报文转发使用。

The binding behavior and kinetics of uncoupling protein with its ligand, the Fourier-transformation infrared spectra of uncoupling protein and its changes during ligand-binding process, the inhibition of Guanosine 5＇-Tetraphosphate (G-4-P) and Adenine-β-Darabinofuranoside 5＇-triphosphate on the binding of uncoupling protein with GTP were studied.

本文对解偶联蛋白与配基的结合及其结合动力学，解偶联蛋白及其与配基结合过程中的傅里叶变换红外光谱及其光谱变化，鸟嘌呤核苷四磷酸（G-4-P）和9-β-D-阿拉伯糖基呋喃5＇-三磷酸对解偶联蛋白与GTP结合的影响进行了研究。

Flow cytometric analysis showed that after mock infection, Ad5null infection, and Ad5hSeFT infection, the mean fluorescence intensity values for the binding of Ulex europaeus Ⅰ lectin to NIH3T3 cells were 2. 3±0.6, 2. 1±1. 0, and 36. 5±5. 9, respectively; MFI values for the binding of Griffonia simplicifolia isolectin B4 (GS-IB4) lectin to NIH3T3 cells were 167±23, 170±19, and 100±14, respectively; MFI values for the binding of human natural IgG and IgM antibodies to NIH3T3 cells were 31±3, 32±4, and 22 ±4, respectively.

流式细胞分析结果表明，小鼠NIH3T3细胞及分别被Ad5null和Ad5hSeFT转导的NIH3T3细胞，UEA-1凝集素结合细胞的平均荧光强度值分别为2.3±0.6、2.1±1.0和36.5±5.9；GS-〓凝集素结合细胞的MIF值分别为167±23、170±19和100±14：人天然IgG和IgM抗体结合细胞的MFI值分别为31±3、32±4和22±4。

Since the binding free energy is the best thermodynamic parameter in charactering the binding affinity of ligand to receptor, it has been used widely in medicinal chemistry and drug discovery and development. The developments of three-dimensional structure determination techniques of macrobiomolecules and computer science allow the binding free energy between drugs and receptors can be predicted accurately.

现在的一些类药性评价规则采用的是和分子大小相关的描述符，所以它们虽然能够有效地将平均分子量较大的&类药性&数据库—MDDR(MACCS-ⅡDrug Data Report)和平均分子量较小的&非类药性&数据库—ACD区分开来，但是却无法有效地区分平均分子量相近的&类药性&数据库—CMC(Comprehensive Medicinal Chemistry)与ACD。

For the high affinity sites, binding constant decreases with the decrease of the alkyl chain lengh in the surfactants, but for the low affinity sites, binding constant increases and are not distinct when the alkyl chain is dedocyl. The binding sites are related to the alkyl chain lengh, not for the number of hydrophile groups and temperature.Isothermal titration calorimetry has been used to observe the enzyme-catalyzed hydrolysis reaction of urea.

对于高结合位点，结合常数随疏水碳链长度的减小而减小；对于低结合位点，结合常数随疏水碳链长度的减小而增大，相应的当碳链减小至C12时，低结合位点不明显，结合位点数可能只与碳链长度有关，随亲水头基和温度变化不明显。

The results of these analysis show that the initial stress of steel stiffened girder has a significant impact on maximum vertical displacement, maximum tensile stress of pavement surface and maximum shear stress of binding course; the deformation of steel stiffened girder has a significant impact on shear stress of binding course; heavy-vehicle load can increase each control index rapidly; the horizontal force of vehicle load has a significant impact on longitudinal tensile stress of pavement surface and longitudinal shear stress of binding course.

分析结果表明钢加劲梁初始应力对铺装层表面最大竖向位移、铺装层表面最大拉应力与粘结层最大剪应力均有显著影响；钢加劲梁变形对粘结层剪应力影响显著；重车荷载将使各控制指标均急剧增加；车辆荷载的水平力则对铺装层表面纵向拉应力与粘结层纵向剪应力影响显著。

Listen,point and check your answers.

听，指出并且检查你的答案。

Warming needle is one of effective treatment methods for knee arthralgia aggravated by cold,and it is simple,safety,so it should be developed in clinical acupuncture and moxibustion extensively.

但以本院科针灸门诊在2005年1月—2006年6月期间共收治膝痛患者100余例，经过临床的诊断后，其中施以温针治疗的48例，疗效显著，报道如下。1临床资料本组病例48