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Cell line analysis showed that the antibody notably reacted to three out of 4 cell lines (Raji, SMS-SB, Nalm-6 and Nall-1) with the positive rates of 98.78%, 98.61%, 94.93% respectively and weakly to one of them with 5.68% in B lineage cell lines and monoblastic cell line (U937, 67.78%) while it was only weakly positive or negative for other myeloid leukemia cell lines including Meg01 (33.40%), HL-60 (29.70%),K562 (28.19%), KG1a (16.23 %) and HEL92.1.7 (8.02%). Among 4 T lineage leukemia,5 neuroblastoma and 1 colon cancer cell lines tested, only Molt-3 was found weakly positive (31.40%) for 2B8a, while the remaining 3 T cell lines (Molt4, JM and CCRF-CEM), 5 neuroblastoma cell lines (LA-N1, KCNR, BE, SK-N-SH, SK-N-AS) and the colon cancer cell line (HR8348) tested were negative.

结果表明: 2B8a抗原在外周血B细胞上表达(3/3例,平均阳性细胞数为26.29 %),而在T淋巴细胞和NK细胞上不表达(0/3例);在粒细胞和单核细胞上阳性表达均为2/3例,平均阳性细胞数分别是23.72 %和59.84 %;在DC细胞、红细胞和血小板上均不表达(0/3例)。2B8a抗原在骨髓CD34+细胞上的阳性表达是3/3例,平均阳性细胞数39.33 %,而在G-CSF动员的外周血CD34 细胞上的阳性表达仅1/3例,平均阳性细胞数为1.25 %。2B8a抗原在B系细胞系Raji、SMS-SB、Nalm-6和Nall-1上的平均阳性细胞数分别为98.78 %、98.61 %、94.93 %和5.68 %;在T系细胞系Molt-3上的平均阳性细胞数为31.40 %,而在Molt-4、JM和CCRF-CEM 细胞上不表达;在髓系细胞系U937、Meg-01、HL-60、K562、KG1a和HEL92.1.7上的平均阳性细胞数分别为67.78 %、33.40 %、29.70 %、28.19 %、16.23 %和8.02 %;在神经母细胞瘤细胞系SK-N-SH、KCNR、BE、LAN-1和SK-N-AS细胞以及结肠癌细胞系HR8348细胞上均不表达,而在羊膜细胞系FL细胞上呈一定的阳性表达,平均阳性细胞数为45.03%。

The examples show that not only two binary complementary sequence pair sets can be used to construct a new binary complementary sequence pair set,but also it can be extended to the design of new binary complementary sequence pair set through several individual ones. This method can extend the existence space of binary complementary sequence pair set.

通过实例表明利用该方法不仅可由两个二元互补序列偶集构造生成新的二元互补序列偶集,并可推广到由多个二元互补序列偶集构造新的二元互补序列偶集的设计中,从而扩展了二元互补序列偶集的存在空间。

This dissertation investigates the construction of pseudo-random sequences (pseudo-random numbers) from elliptic curves and mainly analyzes their cryptographic properties by using exponential sums over rational points along elliptic curves. The main results are as follows:(1) The uniform distribution of the elliptic curve linear congruential generator is discussed and the lower bound of its nonlinear complexity is given.(2) Two large families of binary sequences are constructed from elliptic curves. The well distribution measure and the correlation measure of order k of the resulting sequences are studied. The results indicate that they are "good" binary sequences which give a positive answer to a conjecture proposed by Goubin et al.(3) A kind of binary sequences from an elliptic curve and its twisted curves over a prime field F_p. The length of the sequences is 4p. The "1" and "0" occur almost the same times. The linear complexity is at least one-fourth the period.(4) The exponential sums over rational points along elliptic curves over ring Z_ are estimated and are used to estimate the well distribution measure and the correlation measure of order k of a family of binary sequences from elliptic curves over ring Z_.(5) The correlation of the elliptic curve power number generator is given. It is proved that the sequences produced by the elliptic curve quadratic generator are asymptotically uniformly distributed.(6) The uniform distribution of the elliptic curve subset sum generator is considered.(7) We apply the linear feedback shift register over elliptic curves to produce sequences with long periods. The distribution and the linear complexity of the resulting sequences are also considered.

本文研究利用椭圆曲线构造的伪随机序列,主要利用有限域上椭圆曲线有理点群的指数和估计讨论椭圆曲线序列的密码性质——分布、相关性、线性复杂度等,得到如下主要结果:(1)系统讨论椭圆曲线-线性同余序列的一致分布性质,即该类序列是渐近一致分布的,并给出了它的非线性复杂度下界;(2)讨论两类由椭圆曲线构造的二元序列的"良性"分布与高阶相关性(correlation of order κ),这两类序列具有"优"的密码性质,也正面回答了Goubin等提出的公开问题;(3)利用椭圆曲线及其挠曲线构造一类二元序列,其周期为4p(其中椭圆曲线定义在有限域F_p上),0-1分布基本平衡,线性复杂度至少为周期的四分之一;(4)讨论了剩余类环Z_上的椭圆曲线的有理点的分布估计,并用于分析一类由剩余类环Z_上椭圆曲线构造的二元序列的伪随机性;(5)讨论椭圆曲线-幂生成器序列的相关性及椭圆曲线-二次生成器序列的一致分布;(6)讨论椭圆曲线-子集和序列的一致分布;(7)讨论椭圆曲线上的线性反馈移位寄存器序列的分布,线性复杂度等性质。

This dissertation investigates the construction of pseudo-random sequences (pseudo-random numbers) from elliptic curves and mainly analyzes their cryptographic properties by using exponential sums over rational points along elliptic curves. The main results are as follows:(1) The uniform distribution of the elliptic curve linear congruential generator is discussed and the lower bound of its nonlinear complexity is given.(2) Two large families of binary sequences are constructed from elliptic curves. The well distribution measure and the correlation measure of order k of the resulting sequences are studied. The results indicate that they are "good" binary sequences which give a positive answer to a conjecture proposed by Goubin et al.(3) A kind of binary sequences from an elliptic curve and its twisted curves over a prime field F_p. The length of the sequences is 4p. The "1" and "0" occur almost the same times. The linear complexity is at least one-fourth the period.(4) The exponential sums over rational points along elliptic curves over ring Z_ are estimated and are used to estimate the well distribution measure and the correlation measure of order k of a family of binary sequences from elliptic curves over ring Z_.(5) The correlation of the elliptic curve power number generator is given. It is proved that the sequences produced by the elliptic curve quadratic generator are asymptotically uniformly distributed.(6) The uniform distribution of the elliptic curve subset sum generator is considered.(7) We apply the linear feedback shift register over elliptic curves to produce sequences with long periods. The distribution and the linear complexity of the resulting sequences are also considered.

本文研究利用椭圆曲线构造的伪随机序列,主要利用有限域上椭圆曲线有理点群的指数和估计讨论椭圆曲线序列的密码性质——分布、相关性、线性复杂度等,得到如下主要结果:(1)系统讨论椭圆曲线-线性同余序列的一致分布性质,即该类序列是渐近一致分布的,并给出了它的非线性复杂度下界;(2)讨论两类由椭圆曲线构造的二元序列的&良性&分布与高阶相关性(correlation of order κ),这两类序列具有&优&的密码性质,也正面回答了Goubin等提出的公开问题;(3)利用椭圆曲线及其挠曲线构造一类二元序列,其周期为4p(其中椭圆曲线定义在有限域F_p上),0-1分布基本平衡,线性复杂度至少为周期的四分之一;(4)讨论了剩余类环Z_上的椭圆曲线的有理点的分布估计,并用于分析一类由剩余类环Z_上椭圆曲线构造的二元序列的伪随机性;(5)讨论椭圆曲线-幂生成器序列的相关性及椭圆曲线-二次生成器序列的一致分布;(6)讨论椭圆曲线-子集和序列的一致分布;(7)讨论椭圆曲线上的线性反馈移位寄存器序列的分布,线性复杂度等性质。

The general decoding method for Turbo codes provided by the invention adopts enhanced Max-Log-MAP algorithm, makes use of Max-Sum semiring property in the generalized distribution law and combines and simplifies measure and calculation of forward and backward status of traditional binary Turbo codes, which means combining grid graph of traditional binary Turbo codes in nature to ensure that the status measure and calculation of the traditional binary Turbo codes have the same calculation expression way with that of the duobinary Turbo codes so that a general decoding device can both decode the traditional binary Turbo codes and duobinary Turbo codes.

本发明提出的Turbo码通用译码方法采用增强型Max-Log-MAP算法,利用广义分配率中的Max-Sum半环性质,对传统二进制Turbo码的前向和后向状态度量计算进行合并简化,从本质上也就是对传统二进制Turbo码的网格图进行合并,使得传统二进制Turbo码的状态度量具有和双二进制Turbo码一样的计算表达方式,从而使得通用译码装置对于传统二进制Turbo码和双二进制Turbo码都可实现。

Definition of tree ADT, FirstChild-NextSibling Representation, Tree traversals, Applications of trees, Definitions and properties of binary trees, Traversal of trees, Recursive functions of trees, Threaded binary trees, Binary search trees, AVL trees, Splay trees, B-trees, Application of binary trees.

树的定义,树的兄弟表示法,树的遍历,树的应用;二叉树的定义和基本特性,遍历二叉树,二叉树的递归操作,线索二叉树;二叉排序树,平衡二叉树,Splay树,B-树,二叉树应用。

And another construction methods for perfect and quasi-perfect binary array pairs are presented with the help of the relationships among the perfect, quasi-perfect and double quasi-perfect binary array pairs. On the other hand, a new kind of discrete signal is presented in this paper, which is the punctured binary sequence pair and the punctured binary array pair.

另一方面,本文提出了一种新的离散信号,即屏蔽二进序列偶和阵列偶,建立了完整的屏蔽二进序列偶和阵列偶的理论体系,它包括最佳屏蔽二进序列偶理论、最佳屏蔽二进阵列偶理论、准最佳和双准最佳屏蔽二进阵列偶理论,以及屏蔽二元互补序列偶理论。

With the help of these conditions, computer efficiently searches out many quasi-perfect and double quasi-perfect punctured binary array pairs. The relationships among perfect punctured binary array pair, quasi-perfect and double quasi-perfect punctured binary array pair is presented. Specially, when first and second dimension period of the punctured binary ar

定义了非周期屏蔽二元序列偶的自相关函数、屏蔽二元互补序列偶和最佳屏蔽二元互补序列偶,给出并证明了屏蔽二元互补序列偶的变换性质;和它存在的组合允许条件,用计算机搜索出若干最佳屏蔽二元互补序列偶;给出了屏蔽二元互补序列构造出新的屏蔽二元互补序列偶的四种构造方法;并且,给出了利用不同长度的二元互补序列和屏蔽二元互补序列偶构造出新的屏蔽二元互补序列偶的四种构造方法。

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果:1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长,同时促进细胞的分化和凋亡:白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化,UW228-3、Med-3细胞向神经元细胞方向成熟分化,以100μM作用48小时效果显著;2、四个细胞系均有Fas和Caspase-3表达,但无Fas-L基因表达和蛋白活性产生,因此难以形成Fas相关性死亡通路;3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同:UW228-1,-2,-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达,而Med-3细胞系,白藜芦醇却抑制CYP1A1的表达;四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制;4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变,表现在G0/G1期在整个细胞周期中所占的比例增加,而其它时期则相应减少。

The living cell of L428 cell has experienced from monoclonal to the multi-cell forming process,and presents a big cell around many small clone cell encystation phenomenon.finally,gigantic cells is dead in the life time.3.The cell counting result showed that the proportion of big cell or the H/RS type cell(diameter≥25um)is for(11.6±1.5)%in the L428 group,for(4.6±0.7)%in L428-MVC group and for(13.1±1.3)%in L428-EVC group,respectively.

经持续稀释成单个大细胞、单个小细胞的L428细胞,小细胞可分裂转化成大细胞,大细胞亦可生成小细胞;常见单个大细胞周围出现多个小细胞围绕的现象,在此过程中NF-kB一直持续活化。3。

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