查询词典 berberine

Berberine,a natural plant product, activates AMP-activated protein kinase with beneficial metaboric effects in diabetic and insulin-resistant states.

L -1胰岛素诱导脂肪细胞产生IR，予以8-羟基二氢小檗碱进行干预，以小檗碱作为阳性对照，观察到0.5mmol.L -1软脂酸作用24h或25mmol。

Results: At the concentrations of 0.1, 1 and 10 μmol/L, berberine dose-dependently suppressed the formation of TRAP-positive multinucleated cells, the TRAP activity and the osteoclastic bone resorption. The strongest inhibitory effect was exhibited at the concentration of 10 μmol/L, with the inhibiting rate of 60.45%, 42.12% and 72.69% respectively.

结果：小檗碱在0.1~10μmol/L范围内，浓度依赖性地抑制TRAP阳性多核破骨细胞的形成和TRAP活性，减少破骨性骨吸收陷窝的面积；在10μmol/L浓度下，对破骨细胞的抑制作用最强，对TRAP阳性多核破骨细胞的形成和TRAP活性的抑制率分别达到了60.45%和42.12%，骨吸收陷窝面积减少72.69%。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Objective: To observe the effects of berberine on osteoclastic differentiation and bone resorption action in vitro, and to investigate the cellular mechanism of its inhibitory effects on bone resorption.

目的：研究小檗碱对破骨细胞分化及骨吸收功能的影响，探讨小檗碱抑制骨吸收的细胞学基础。

It is researched by specific conductance that ultrasound has an effect on yield of berberine ingredient from extracted phellodendron amurense.

采用电导率测试法研究了超声提取对药材黄柏中小檗碱成分产额的影响。

Methods The scutell aria and phellodendron were identified by thin layer chromatography and the content of berberine hydrochloride was determined by thin layer chromatography scanning.

采用薄层色谱法对处方中的黄柏和大黄进行定性鉴别；用薄层扫描法测定黄柏中盐酸小檗碱的含量。

The aim of this experiment is to determine the amount of berberine in 12 kinds of crude plants of Coptis and 16 kinds of Phellodendron and 49 kinds of drug preparations which have Coptis and Phellodendron or one of both sold in Taiwan mark now.

本实验的目的系针对台湾目前市场出售之黄连、黄蘗中药材及其制剂作一普遍的抽样调查，以明了其所含小蘗量之差异。

Improved Franz diffusion devices was used with four index ingredients as evodiamine, rutaecarpine, palmatine and berberine that were determined by HPLC in one mobile phase.

试验采用改良Franz扩散装置，用HPLC法使用1种流动相测定接收液中吴茱萸碱、吴茱萸次碱、巴马汀、小檗碱4种指标成分的含量。

METHOD:Using TLC scanning and spectrophotography to determinate the content of berberine hydrochloride.

采用薄层扫描法和分光光度法测定盐酸小檗碱的含量。

The glucose consumptions of insulin resistant model of HepG2 and 3T3-Ll adipocyte were promoted by some drugs such as stachyose, berberine and ginsenoside.

某些中药提取成分（如水苏糖、小檗碱和人参皂苷等）能促进HepG2胰岛素抵抗模型和3T3-L1脂肪细胞胰岛素抵抗模型的葡萄糖消耗。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。