查询词典 berbamine

Objective To study the effects of berbamine and batiolun on LDH metabolizability in the process of increasing leukocyte.

目的 研究小檗胺和鲨肝醇升高白细胞作用及对细胞内LDH的代谢的影响。

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Base on the result, a new antiarrhymic drug model was established, and the molecular mechanism was clarified why matrine and berbamine were not so effective on arrhythmia compared to amiodarone and RP58866. The antiarrhythmic mechanism of Chinese traditional drugs cyclovirobuxine D and water extracts from codyceps sinensis was investigated, and a scheme was produced to potentize the afficacy of antiarrhythmic Chinese traditional drugs.

在此基础上，建立了一种新的抗心律失常药物模型，阐明苦参碱和小檗胺抗心律失常作用弱于胺碘酮和RP58866的分子机制；并探讨了中药环维黄杨星D、冬虫夏草水提液抗心律失常作用机制，提出了增强抗心律失常中药效能的方案。

Objective: To determine effects of berbamine on the growth of leukemia cell line NB4 and explore its possible mechanisms.

目的：探讨小檗胺对白血病细胞系NB4生长的影响及其机制。

To explore the mechanism of berbamine inducing apoptosis in human leukemia Jurkat cells.

研究小檗胺诱导人白血病Jurkat细胞凋亡的机制。

Objective To study the effects of berbamine and batiolun on LDH metabolizability in the process of increasing leukocyte.Methods Enzyme biochemical techniques is used to study the effect of berbamine and batiolˉun in the process of inceasing leukocyte and also to study the effect of LDH metabolizability.

目的 研究小檗胺和鲨肝醇升高白细胞作用及对细胞内LDH的代谢的影响方法采用酶细胞化学方法，对两药物在治疗由免疫抑制剂环磷酰胺所致的白细胞减少症时，对乳酸脱氢酶活性的影响进行了比较观察。

objective to study the effects of berbamine and batiolun on ldh metabolizability in the process of increasing leukocyte.methods enzyme biochemical techniques is used to study the effect of berbamine and batiolˉun in the process of inceasing leukocyte and also to study the effect of ldh metabolizability.results when leukocyte is inhibited by the immune inhibitor cycolophosphamcide,berbamine and batiolun are compared of the effect of ldh activity.conclusionthe study draws the conclusion that both berbamine and batiolun can increase thegranule cell,and they also have some effect of the ldh metabolizability.

目的 研究小檗胺和鲨肝醇升高白细胞作用及对细胞内ldh的代谢的影响。方法采用酶细胞化学方法，对两种药物在治疗由免疫抑制剂环磷酰胺所致的白细胞减少症时，对乳酸脱氢酶活性的影响进行了比较观察。结果小檗胺和鲨肝醇均可升高粒细胞，同时对细胞内ldh的代谢有一定的影响。结论小檗胺和鲨肝醇能使外周血粒细胞增加，可用于治疗多种因素引起的白细胞减少症。

Results］ Berbamine could significantly inhibit the proliferation of Jurkat cells in a dose-dependent manner and the IC50 value was 6.6±0.5μg/ml at 48 hours. Berbamine also selectively induced apoptosis of Jurkat cells which were arrested in the S phase. In addition, expression of caspase-3 protein of Jurkat cells increased after exposure to berbamine.

结果］ 小檗胺能选择性抑制人白血病Jurkat细胞生长且呈浓度依赖关系，作用48h Jurkat细胞IC50值为6.6±0.5μg/ml；小檗胺能诱导Jurkat细胞凋亡，使细胞周期阻滞于S期；同时细胞caspase-3蛋白表达增高。

Results Berbamine could significantly inhibit the proliferation of Jurkat cells in a dose-dependent manner and the ICso value was 6.6±0.5μg/ml at 48 hours. Berbamine also selectively induced apoptosis of Jurkat cells which were arrested in the S phase. In addition, expression of caspase-3 protein of Jurkat cells increased after exposure to berbamine.

结果小檗胺能选择性抑制人白血病Jurkat细胞生长且呈浓度依赖关系，作用48hJurkat细胞IC50值为6.6±0.5μg/ml；小檗胺能诱导Jurkat细胞凋亡，使细胞周期阻滞于S期；同时细胞caspase-3蛋白表达增高。

Results: The growth of NB4 cells was inhibited significantly after treated with berbamine at different concentrations for different time points, the IC50 value was 3.860μg/ml at 48 hours. Morphology analysis showed the characteristics of apoptosis, and the DNA agarose electrophoresis showed the typical DNA ladder. The apoptosis rate increased from 2.83% to 58.44% after treated with berbamine at 12μg/ml for 18 hours. The expression of PML-RARα mRNA presented no significant changes, however, Survivin mRNA was decreased dramatically.

结果：经不同浓度小檗胺处理不同时间后，NB4细胞生长出现明显的抑制，并呈现明显的时间剂量依赖性，48h IC50为3.860μg/ml；细胞形态学观察可见细胞凋亡现象，DNA琼脂糖电泳显示典型的凋亡梯形图：流式细胞仪检测发现细胞凋亡率明显增加，经48h作用后，凋亡率从2.83%增至12μg/ml时的58.44%；虽未发现药物作用后PML/RARα基因表达量的改变，但检测到NB4细胞经药物作用后Survivin基因表达量的减少和Caspase3表达的增加，Caspse3阳性率从对照组的2.06%增至12μg/ml时的70.89%。

Lugalbanda was a god and shepherd king of Uruk where he was worshipped for over a thousand years.

Lugalbanda 是神和被崇拜了一千年多 Uruk古埃及喜克索王朝国王。

I am coming just now,' and went on perfuming himself with Hunut, then he came and sat.

我来只是现在，'歼灭战perfuming自己与胡努特，那麼，他来到和SAT 。