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Of 150 cycles could be applied without dose modifications or delay. Leucocytopenia grade 3/4 was observed in 15%, anemia in 7%, and thrombocytopenia in 49% of the patients. Grade 3/4 nonhematologic toxicities (diarrhoea, nausea and neurotoxicity) occurred in one patient each (2%).

在150个疗程中,51%的疗程不需要调整剂量或延迟化疗时间。15%患者出现3/4级白细胞降低,7%患者出现贫血和49%的患者有血小板降低。2%患者(各有1例患者)出现3/4级非血液学毒性。

Methods: 17 cases (12 thoracic vertebra and 5 lumbar) underwent percutaneous vertebroplasty of biotic autogeneic bone marrow and resorbent gains. the treatment results and complications were observed. furthermore, in order to compare the pain degrees between preoperation and postoperation, the pain scale and dallas score were recorded in all cases during preoperation and postoperation, and the above records were transmitted to data which could be analyzed by computer with the help of the statistic of spss 10.0. results: after an average follow-up of 6 months, the symptom of lumbodorsal pain of all cases were relieved in 8 to 24 hours after operation.

采用经皮椎体成形术,注入复合生物型自体红骨髓磷酸钙水泥加可吸收颗粒治疗骨质疏松性脊柱骨折17例,包括胸椎12例,腰椎5例;平均随访6个月,观察手术疗效和并发症情况,同时以疼痛分级和dallas评分的形式记录术前、术后的相应得分,通过量化后的数据,应用统计学软件进行统计分析,评价术后疼痛缓解情况。

At present, these complications were thought by many scholars to be related to maloperation, lesion or anatomy variation of middle nasal turbinate, infections and the degree of lesion and so on (1, 2), while the injuries of nasal mucosa induced by light and heat in transnasal endoscopic sinus surgery were neglected, thus we observed these injuries through animal experiments.

目前,多认为这些并发症与手术操作不当、中鼻甲有病变或解剖变异、感染性病变以及病变程度严重等有关,忽视了鼻内镜术中光和热对鼻粘膜的影响,我们通过动物实验,取不同光照时间的兔的鼻中隔粘膜制作扫描电镜和透射电镜标本,对此进行了观察。

It was also observed that the malpighian tube of Daphnia magna is the more sensitive than the other organs. The present study indicate that the embryo development test with target organ effected rate were more sensitive than traditional acute toxicity test. Suggest that the method may be apply in environmental toxicants evaluation.

透过大水蚤各标的器官之生长试验比较,可明确观察出试验药剂对大水蚤生长及器官之影响,比传统水蚤稚虫急毒性试验对於药剂可以有更深入的解释,可实际应用於环境中的毒物侦测。

The results showed that most of the microbes could be inactivated for the ultra high pressure treatment, the accumulation of total volatile basic nitrogen was restrained, and the change of pH value was delayed. The shelf life of white shrimp was prolonged with the enhancement of high pressure. High pressure treatment could make fresh shrimp with boiled flavor in some degree. Trements of 400 Mpa and 600 MPa aggravated blackening. However, melanotic reaction was not observed during the whole storage of shrimp treated by 700 MPa. High pressure could change the metabolizing of ATP and its metabolites, but did not impact the metabolic pathway of AMP decomposition.

结果表明:超高压处理可以有效地杀灭南美白对虾中绝大多数微生物,抑制贮藏过程中挥发性盐基氮的积累,延缓pH值的变化,从而延长南美白对虾的货架期,且处理压力越高延长效果越显著;超高压处理会给鲜虾带来不同程度上的煮熟虾的风味;400 MPa和600 MPa处理使虾在冷藏过程的黑变提前,而700 MPa处理可以完全抑制南美白对虾黑变现象的发生;超高压能够改变腺苷三磷酸及其代谢产物的代谢情况,但不影响腺苷酸的代谢途径。

Despite the poor response rates in the chemotherapy-alone group, Dr. Burstein believes that metronomic chemotherapy combined with bevacizumab should be investigated further, given the tolerability of the agents and the preclinical rationale for efficacy. When asked why cyclophosphamide and methotrexate were selected for metronomic chemotherapy, he observed that many patients in this setting are already somewhat chemotherapy-resistant.

尽管只接受化学疗法的病患反应率很低,Burstein医师相信节律性化学疗法加上bevacizumab应该进一步研究,因为该药物的耐受性良好,而且临床前实验认为是有效的;当被问到为什么选择cyclophosphamide与methotrexate作为节律性化学疗法的药物,他观察发现,许多病患在这个时候已经对许多化学疗法产生抗药性。

Despite the poor response rates in the chemotherapy-alone group, Dr. Burstein believes that metronomic chemotherapy combined with bevacizumab should be investigated further, given the tolerability of the agents and the preclinical rationale for efficacy. When asked why cyclophosphamide and methotrexate were selected for metronomic chemotherapy, he observed that many patients in this setting are already somewhat chemotherapy-resistant.

尽管只接受化学疗法的病患反应率很低,Burstein医师相信节律性化学疗法加上bevacizumab应该进一步研究,因为该药物的耐受性良好,而且临床前实验认为是有效的;当被问到为什麼选择cyclophosphamide与methotrexate作为节律性化学疗法的药物,他观察发现,许多病患在这个时候已经对许多化学疗法产生抗药性。

No entire nitrendipine crystals were observed visually in SEM photos. The results of X-ray diffraction and differential scanning calorimetry analysis indicated that the crystalline form of nitrendipine was highly dispersed in microspheres, so as amorphous state. The drug release rate of microspheres could be controlled with adjusting the ratio of solid dispersion carriers and retarding agents formulated. The agitation speed and temperature of the preparation process have distinct effect on micromeritic properties of microspheres. The release profiles of the microspheres were mainly affected by the stirring rate of paddle, the concentration of SDS and pH of dissolution medium. Cooling speed and time, however, have no evident influence on the drug release rate of the microspheres. The dissolution data showed that the mechanism of drug release from microsphers was mainly diffusion-controlled. The incorporation efficiencies of 3 batches sample were exceed 96. 8%, which implied that the current method was suitable for design sustained-release dosage form for poorly water-soluble drug.

在扫描电子显微镜下观察,在微球内外未发现尼群地平的完整结晶,X-射线粉末衍射和差示扫描量热试验结果也显示,尼群地平已经被高度分散在微球中;微球的释药速度可通过调整处方中固体分散体载体和阻滞剂的比例控制;制备温度和搅拌速度对微球的质量影响较大;溶出仪的搅拌速度,释放介质的浓度和pH对微球的释放有较大的影响;制备过程中的冷却速度和冷却时间对微球的释放行为影响不很明显;方程拟合的结果表明缓释微球的释药行为符合扩散机制;测定三批微球样品的包封率均在96.8%以上,表明该法适合于制备难溶性药物的缓释微球。

The results show that the radiative properties of randomly distributed soot aggregates for a given fractal dimension are complex functions of the monomer diameters, the number of monomers in the aggregates,and the refractive index; For a small value of the monomer diameters, the absorption cross section of soot aggregates tends to be relatively constant when the fractal dimension is small but increases rapidly when the fractal dimension exceeds two. However, a monotonical reduction in light absorption with the increase of the fractal dimension is observed for soot aggregates with sufficiently large monomer diameters, number of monomers,and refractive index. The scattering cross section , extinction cross section and single-scattering albedo increase monotonically with the increase of the fractal dimension. Overall, the results for soot aggregates differ profoundly from those calculated for the equivalent spherical particles, and the discrepancies between them will change small with the increase of the fractal dimension.

研究表明,在给定分形维数的情况下,烟尘団簇粒子的辐射特性取决于原始微粒粒径、数量及复折射率;原始微粒较小的団簇粒子,当分形维数较小时,吸收截面变化不明显,但当分形维数大于二时,吸收截面骤然增大,然而,对于具有比较大的原始微粒粒径、数量及复折射率的烟尘団簇粒子,吸收截面随着分形维数的增大而单调递减;随着分形维数的增大,団簇粒子的散射截面、消光截面及单次散射反照率均单调递增;从整体上来讲,団簇粒子的辐射特性与等效球形粒子的辐射特性存在着比较大的差别,并且这种差别随着分形维数的增大而减小。

Results showed that urokinase at 20U/ml was the optimal concentration used. Fibrinolysis kinetics and plasma plasminogen concentration of 27 normal persons and 27 patients with acute myeloblastic leukemia were detected, a significant difference was observed between the two groups. Repetition test showed that the coefficience of variation was 5.24±1.51%. This method could also be used to detect the concentration of plasma fibrinogen.

结果 初步建立了正常人纤溶动力学分析参数,确定了20U/ml尿激酶为最适试验浓度,检测22例正常人,27例急性髓细胞白血病患者纤溶动力学及纤溶酶原含量,显示患病组较正常组差异有显著意义(P.05, P.01),重复性试验显示该方法的变异系数为(5.42±1.51)%,并可同步测定血浆纤维蛋白原浓度。

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