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Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.
基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因,通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到,并与疾病的发生、发展存在一定关系,应用甲基化抑制因子或砷剂去甲基化治疗,恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。
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The hypertension model rats were induced with bi-kidney-bi-clip method, then the focal cerebral ischemia-reperfusion rat model was induced by reversible occlusion for a middle cerebral artery with a thread on the stroke prone renovascular hypertensive model rat. While the rats in sham operation group were operated without thread insertion. Shuigou (Du 26), bilateral Neiguan(PC 6) and bilateral Housanli (Zusanli, ST 36) were located according to"Atlas of Experimental Animal Acupoints" made by Hua's. Shuigou (Du26): 1 mm below nasal apex right on the Labium leporinum, be punctured 1 mm obliquely upward; Neiguan (PC 6): at the lateral palm of the forearm3 mm above wrist joint, between ulna and radius, be punctured 1 mm perpendicularly; Housanli (Zusanli, ST 36): under knee joint, 5 mm below the capitulum of fibula, be punctured 7 mm perpendicularly. The skin of Shuigou (Du 26) and the root of right ear, Neiguan (PC 6) and Housanli (Zusanli, ST 36) were connected with electroacupuncture Therapeutic Instrument G6805 with the parameters of continuous wave, 120 times/minute in frequency, 1 mA in intensity for 30 minutes.
用双肾双夹法复制易卒中型肾血管性高血压模型,在此基础上,运用栓线法制备大鼠局灶性脑缺血再灌注模型;假手术组除不插入栓线外,其余步骤同模型组;电针治疗组取水沟(唇裂鼻尖下1 mm正中处,向上斜刺1 mm)、双侧内关(前肢内侧,离腕关节约3 mm处的尺桡骨缝间,直刺1 mm)、双侧足三里(膝关节下侧,在腓骨小头下约5 mm处,直刺7 mm)水沟穴与右耳根部皮肤、内关与足三里接G6805电针治疗仪,连续波,频率120次/min,强度1 mA,留针30 min。
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Wuxia area was located on the eastern of northwest Junggar basin, it was a zone of bruchfalten affected by multiphase tectonic activity, have many faults and its fold morphology were very complicated, underwent three large structural activities, which happened in the late Hercynian movement, Indo-Chinese movement, and the Yanshan movement, by this,strata of Wuxia area can be divided into two primary tectonic sequences and seven secondary tectonic sequences, on plane, Wuxia area can be divided into three secondary structural units from north to south,they are foreland thrust belt, Wuxia fault fold belt and monocline belt, further, from west to east Wuxia fault fold belt can be divided into four fault fold belts.
乌夏断裂带位于准噶尔盆地西北缘冲断带东段,是一个受多期构造叠加影响的断褶带,断裂发育,褶皱形态复杂,自成盆期以来经历了海西、印支、燕山和喜马拉雅等多期构造运动,可划分为2个一级构造层序和7个亚构造层序,可划分出山前冲断带、乌夏断褶带、南部单斜带三个次级构造单元和四个更次一级的构造单元。
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In the winter solstice this day, regarding was located Northern Hemisphere's Taiwan, by now the solar just perpendicular incidence (was called the winter solstice line) in the the tropic of capricorn on, caused Taiwan to be in the winter the season, therefore caused Northern Hemisphere's daytime to be shortest, the dark night was longest.
在冬至这一天,对于位于北半球的台湾,这时太阳刚好直射在南回归线上,使得台湾处于冬季的季节,因此使得北半球的白天最短,黑夜最长。
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Article 20: The wage of a worker during his/her probation period may not be lower than the lowest rung on the wage scale for the same position with the Employer or 80% of the wage specified in the employment contract, and may not be lower than the minimum wage rate in the place where the Employer is located.
第二十条劳动者在试用期的工资[y13] 不得低于本单位相同岗位最低档工资或者劳动合同约定工资的百分之八十,并不得低于用人单位所在地的最低工资标准。
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Photonic quantum-well structures can be constructed by stacking 3 photonic crystals with the same photonic band gap and different defect modes. On condition that the defect mode of the PC in the well region is located into nontransmission frequency ranges of the PCs in the barrier regions, the confined photonic state appears and can completely transmit through the structure by tunneling. However, its transmission will be strongly prohibited due to vanishing of the photonic QW induced by shifting the defect mode frequency of either of the PCs in the surrounded regions to that of the middle PC.
把三块各带有一个缺陷的光子晶体结合起来,如果中央晶体的缺陷模处在两侧晶体的禁带中,缺陷模内的光波会受到两侧晶体的阻碍并被局域在中央晶体内,形成量子阱结构;若一侧晶体的缺陷模被移动到中央晶体缺陷模处,则只有一侧晶体阻碍在中央晶体缺陷模内传播的光波,量子阱效应完全消失,光的传输受到最大程度的阻碍。
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There are the main theme of care investment plate is still the key, blue-chip plate driving force in the sector to do so under the current account will补涨opportunities exist, it is clear that the end market is not calm, in this column that the existence of multi-year opportunity, although the index is not identified up expectations, but shares the opportunity to be very rich, worthy of our attention, attention should be paid to operational tempo grasp, do not blindly chasing high attention to controlling positions, located good stops.
有投资的照顾板的主题仍然是关键,蓝筹板块的推动下做部门经常项目,使部队将补涨机会存在,很明显,最终市场并不平静,在此列,认为存在多岁的机会,虽然指数没有达到预期确定,但股价的机会非常丰富,值得我们注意,要注意运作节奏把握,不要盲目追求高注意控制阵地位于良好停止。
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Cyclophos phamide fit a paper width slightly less than the minimum machine design business card printing and membership card when making the size of the paper is in axial centered, the regulation may pull side to the original paper, in which case the relative to the printing plate location is a little more deflexions business card printing and membership card when side syndiospecific is located, accordingly, the paper will also be a slight deviation business card printing and membership card making machine axial and lateral lawyers'gowns syndiospecific side may makes side syndiospecific la get paper, because the format is too small to be business card printing and membership card making paper can business card printing and membership card was produced.
纸张的宽度稍微小于机械安排的最小制卡和会员卡制作尺寸,当纸张处于轴向居洋场所时,不正规不定不推不到纸张,这时把原版出入于印版的场所稍微方向制卡和会员卡制作时不正规所在外,相答不天,纸张也不兵稍微偏即制卡和会员卡制作机轴向而方向不正规外通功,不定不离可以让不正规不推获得纸张,本来因为幅背太小而无法制卡和会员卡制作的纸张不离可以制卡和会员卡制作了。
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The guard rail has many kinds of explanations, may be in the industry uses, uses in protecting the industrial equipment, the facility, these guard rails are very generally solid, the material request is also quite strict; We refer to generally the guard rail is the guard rail net, generally is the wire netting wall, yesterday I have gone to a Yantai some work site dewatering excavation scene, located at the inhabited area, the construction road section is mainly some large-scale freight vehicles and the resident passes through, although the project is the seal construction, only passes through for the pedestrian, also has displayed the project notice board in the work site east side, but nearby the deep two meter big hole pit several simple guard rails, between the guard rail only some warning line a little truly cannot only be justified.
提示: 您现在查看的是分类妈妈关于烟台护栏的信息,如果您不满意,请登录咨询建议留言,让我们共同打造港城新媒体!烟台分类妈妈消息,今天一尾号是9820的网民来电说想告诉大家一条关于烟台护栏的相关信息:护栏有多种解释,可以是工业上用的,用于保护工业设备、设施,这些护栏一般很结实,材料要求也比较严格;我们一般指的护栏是护栏网,一般为铁丝网墙,昨天我去了一趟烟台某工地的排水工程现场,位于居民区,施工的路段主要是一些大型货车和居民通行,虽然工程为封闭施工,仅供行人通行,也在工地的东侧摆上了工程公告牌,但深两米的大坑坑边仅有几个简易的护栏,护栏间仅有一根警戒线确实有点说不过去。以上就是这位热心的朋友为大家介绍的关于烟台市护栏的相关问题的相关信息,希望烟台市民能够满意加喜欢,以下是简单的英文介绍希望老外朋友们也喜欢
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To take all steps and remedies necessary and proper for the conduct and management of my business affairs, and for the recovery, receiving, obtaining and holding possession of any lands, tenements, rents or real estate, goods and chattels, debts, interest, demands, duties, sum or sums of money or any other thing whatsoever, located anywhere, that is, are or shall be, by my said attorney-in-fact, thought to be due, owing, belonging to or payable to me in my own right or otherwise
为了管理我的商业事务,为了追索、接收、获得和占有任何土地、房屋、租金或不动产、货物和动产、债务、利息、合法要求、义务、所有金钱以及我的该代理律师认为或将认为属于我所有或应付给我所有的任何以上财产,我的律师都有权采取一切必要和适当的步骤和补救措施。
- 推荐网络例句
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But we don't care about Battlegrounds.
但我们并不在乎沙场中的显露。
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Ah! don't mention it, the butcher's shop is a horror.
啊!不用提了。提到肉,真是糟透了。
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Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.
Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。