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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

While the emerging cold war, the geopolitical value of the Middle East became contemporaneously linked to the policy of containment to the Soviet Union by Washington.

冷战期间，美国将中东的地缘政治价值与遏制苏联战略紧密结合，致力于阻止苏联在中东的影响。

With this information, the photos from different Image Space users are contextually linked between each other as well as create a better understanding of the place that the users browsing.

有了这些信息，从不同的图像空间用户的照片与内容之间的相互联系，以及创建一个更好地了解地方的用户浏览。

Then the thesis chooses a unit-linked insurance contract to do demonstration study, and gets the result and the distribution of the present value of contingent liability of the GMDB, then analyzes the factors which may have influences on the result.

在此收益率模型之下，针对我国市场上现有的投资连接保险保单进行实证分析，得到了最低死亡保证给付的或有负债现值的模拟结果，最后对这个结果的影响因素进行了详细的分析。

A unit?linked life insurance contract is a contract where the insurance benefits depend on the price of some specific traded stocks.

单位连结人寿保险合同是保险利益依赖于某特定股票的价格的保险合同。

This is done by synchronised jacks. The jacks are linked by control cables and controlled by one person from a control desk.

这要由同步架车机完成，架车机由控制电缆联在一起，由操作人员在控制台上控制。

An automatic control system in which various control units are linked in sequence.

各个控制单元按顺序连接的自动控制系统。

An automatic control system in which various control units are linked in sequence, each control

各个控制单元按顺序连接的自动控制系统，每个单元控制下个单元的操作。

Because the real estate economy controlled directly or indirectly 40% of the market value of listed companies for real estate in which the weight of very large, the stock market, the property market has become more closely linked.

因为，香港地产经济直接间接控制的上市公司占到市值的40％，地产在其间占的分量非常大，股市、楼市联系也更为紧密。

Those two sluts that night in the Coombe, linked together in the rain.

那天晚上在库姆，两个娘子淋着雨，互相挽着臂在唱

Nowadays, most of research are to build a transmutative Petri Nets through adding controlling place sets, controlling arc sets and controlling policy to the basic Petri Nets, while the Controlled Petri Nets could be used to argue many controlling theory problems conveniently and to induce many logically and physically supervisory and solve the Event Feedback Controlling Problems and State Feedback Controlling Problem in DEDS supervisory theory.

目前大多数的研究表现为在变形后的受控Petri网基础上，利用各种方法求得各种逻辑型、结构型控制器，解决DEDS监控理论中的事件反馈控制问题与状态反馈控制问题。

On one hand, there are discussions with the works council and union about extension of short time working up to the end of September.

一方面，有讨论，工程理事会和联盟关于延长工作时间短至9月底。