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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Notwithstanding any provision to the contrary in this insurance a claim for loss or damage to any machinery , shaft, electrical equipment or wiring, boiler condenser heating coil or associated pipework, arising from any of the perils enumerated in Clause 622 to 625 inclusive above or from fire or explosion when either has originated in a machinery space, shall be subject to a deducible of Any balance remaining, after application of this deductible, with any other either has originated in a machinery space, shall be subject to the deductible in Clause 121

尽管有与本保险相反的任何规定,对于因遭遇第622项至625项列举的各项危险包括源于机舱的火灾或爆炸造成的任何机器、轴、电器设备或电线、锅炉冷凝器、暖油盘管,或附属管道的损害提起的索赔,应扣除免赔额,扣除该免赔额后的任何余额,与因同一事故或事件引起的任何其他索赔一道,应受第121款的免赔额的制约。第122 款和123款的规定,应适用于根据本条提出的任何索赔获得的赔偿及该保险赔偿所含的利息。

Finally, the author proves the sharp bound for the indices of convergence of n*n reducible Boolean matrices with f〓≥2 the writer lets f〓 be the greatest common divisor of the distinct lengths of the elementary cycles of the associated digraph D (A for a reducible Boolean matrix A , and characterizes the matrices with the largest index.

最后,设f〓为可约布尔矩阵A的伴随有向图D的所有圈长的最大公约数,当f〓≥2时,我们得到了可约布尔矩阵幂敛指数的一个上界和达到最大幂敛指数的矩阵的完全刻划。

Survey shows that the real estate industry is a major means of tax evasion: individual real estate enterprises to take advantage of off-the-books, accounting, false invoices for the apparent increase of tax evasion; part of the real estate business to avoid tax regulation, does not accurately pre - pay corporate income taxes; own Jian'an inflated costs, the cost ratio does not follow the principle of carry-over, corporate profits as the year in advance the size of carry-over costs, man-made regulation of profits, corporate income tax evasion; together to build the party issuing false invoices, the expansion of another party development costs, the transfer of profits, corporate income tax evasion; advance purchase transactions shall be pegged not to declare their taxable accounts, low-priced sale of product development, drilling policies do not take advantage of value-added tax timely clearing of land; sales garage, storage room through the non-Non-invoiced transfer income, tax evasion related taxes; way to reduce the recording of non-existent staff made售房sales royalty income, personal income tax evasion; with branches or associated enterprises business is not a normal transaction between independent enterprises, and through cross-cutting shared billing or concealed operating items, operating income to conceal tax evasion; bank into the personal housing mortgage loans credited to the "short-term borrowing" subjects, the transfer of income, tax evasion business tax, land value-added tax and enterprise income tax; will develop products for their own use, foreign donations, to cover the debt in exchange for non-monetary assets are not regarded as sales in accordance with the regulations and carry-over income, tax evasion related taxes.

调查显示,房地产业是一个重要的手段逃税:个别房地产企业利用账外账,会计,假发票的情况明显增加逃税;部分房地产业务,以避免税收调节,并没有准确地预先-支付公司所得税;夸大自己的建安成本,费用率并不遵循结转,企业利润为提前一年规模结转成本,人为调节利润,逃避企业所得税;共同建设党的虚开发票,扩大另一方开发成本,转移利润,逃避企业所得税;预购交易应盯住不申报应纳税帐户,低价销售的产品开发,钻政策不利用增值税及时交换土地;销售车库,储藏室通过非非发票转让收入,偷税漏税有关的税收;方式,以减少该记录不存在的工作人员取得售房销售版税收入,逃避个人所得税;与分支机构或关联企业的业务不是一个正常的独立企业之间的交易,并通过交叉共享帐单或隐瞒经营项目,隐瞒经营收入逃税;银行的个人住房按揭贷款记入"短期借款"科目,转移收入,偷税漏税营业税,土地增值税和企业所得税;将开发的产品供自己使用,外国捐款,用于支付债务,以换取非货币性资产不视为销售依照条例和结转收入,偷税漏税有关的税收。房价上涨后,股市下跌

It will always be a paradox how a man who could so effortlessly connect with the public mood – sentimental after the death of Princess Diana in 1997, defiant after the London bombings in 2005 – could by the end become so associated in the public mind with shiftiness, spin and sleaze, against which, his professions of sincerity offer no defence.

在公众心目中,一个曾经极易与公众情感联系起来的人(1997年戴安娜王妃去世时的感伤、2005年伦敦爆炸事件后的坚强),最后怎么会与善变、炒作和肮脏勾当联系得如此紧密呢?这将永远是一个悖论。对于上述三种形象,他的诚挚表白无法提供有力的辩护。

Dr. Grinspoon was quick to point out that the results by themselves do not support the use of growth hormone as treatment in patients with lipodystrophy. On the other hand, if it were to be done, the doses needed might be much smaller than used in HIV-associated wasting, perhaps as low as simple replacement, which may be 5% to 10% of the doses currently being used.

Grinspoon博士敏锐地指出,这一结果并不支持利用生长激素来治疗脂肪营养不良患者;另一方面,即使采用这种疗法,剂量也应比目前治疗HIV相关性消瘦所用剂量低得多,可能仅相当于单纯替代剂量,即约为目前所用剂量的5%-10%。

Viral vector mainly contain adenovirus, retrovirus,adeno-associated virus and so on, but it has potential danger of safety; it isrepeled by immune system when it is injected to organism for a greatimmunogenicity. An injection with adenovirus vector with highconcentration, it leads to serious inflammatory reaction of liver. Viralvector such as liposome and polycation are commonly used lately. But,liposome and polycation have low specificness and targetness of genetransfer tissue, have lower transfection efficiency and short period ofgene expression, for they can be phagocytized by endothelial system.

许多的载体,病毒载体和非病毒载体以前已广泛应用,病毒载体主要包括腺病毒,逆转录病毒,腺相关病毒等;但病毒载体在安全性方面存在潜在的危险;免疫原性比较强,注射到机体后很快会被机体的免疫系统排斥,当静脉注射高浓度的腺病毒载体会使肝脏发生严重的炎症反应;非病毒载体目前常用的有脂质体及多聚阳离子聚合物;但脂质体和阳离子聚合物介导基因转移缺乏组织的特异性和靶向性,转染效率较低且易被网状内皮系统吞噬,基因表达时间短;因此研制新型的非病毒载体已成为研究的热点,纳米颗粒具有小尺寸效应,表面效应,随着颗粒直径变小,比表面积将会显著增大,故具有很高的化学活性,因而纳米成为了最有应用前景的非病毒载体。

Article 57 Where the valuation or the receipt or payment of usage fees in respect of such business dealings as the transfer of property or the granting of rights to the use of property between an enterprise and an associated enterprise is not based on business dealings between independent enterprises, adjustments may be made thereto by the local tax authorities with reference to amounts that would be agreed to by unassociated and unrelated parties.

第五十七条企业与关联企业之间转让财产、提供财产使用权等业务往来,不按独立企业之间业务往来作价或者收取、支付使用费的,当地税务机关可以参照没有关联关系所能同意的数额进行调整。

A total of34 markers were found to be significant associated (P<0.001 ) with the five grain color traits,which showed these traits were controlled by polygenes with minor effects.

不过各个位点的贡献率都比较小,表明在白米材料群体中,其颜色参数性状受微效多基因控制,其遗传方式比较复杂。

Additionally, one SsDRV-free strain Ep-1PNA183av that showed hypovirulence was isolated from a mutant of healthy strain Ep-1PNA183, this strain also immunizes the infection of SsDRV, it would be a valuable material to study on the interaction between SsDRV and its host. Surprisingly, we discovered that SsDRV could be transmitted into S. nivalis (in the same genus to S. sclerotiorum) when cultured side by side on PDA plate, this discovery may supply new evidence for the exchange of genetical elements among different species in fungi; the transmission of mycovirus to other species showed that the limitation of vegetative imcompatiblity among different strains might not be key factor to determine the efficiency of biological control with hypovirulence associated mycovirus.

发现了1株不携带SsDRV的核盘菌弱毒力菌株,该菌株对SsDRV具有显著抗性,是研究SsDRV与寄主互作的宝贵材料;还发现SsDRV可以在核盘菌种间传递,深入研究将为生物在种间的遗传物质交换提供了新的证据,也将为广泛利用弱毒相关病毒控制植物病害提供理论依据。

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The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为:以确有疗效的中药复方为研究对象,以现代科学技术和传统中医药理论为技术支持,以该复方所治病证的药效响应为评价标准,以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。

I don't… don't know. He's unconscious.

我不……我不知道他休克了。