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Epigenetics refer to the study of expression of the affected genes that can be mitotically inherited, including modifing the gene transcription and translation, but is not associated with the changes in the coding sequence of the affected genes.

因此，经典的基因改变遗传调控理论无法完全解释大肠癌相关基因的激活或失活〓，并逐渐认识到Epigentics和DNA序列改变的遗传机制都参与肠癌的发生和发展〓。

The ureteroscopic holmium: YAG laser lithotripsy can he the first choice for the post-renal acute renal failure associated with upper urinary tract stones, due to its safety and efficiency. At the same time, retrograde intubation under cystoscope and percutaneous nephrostomy will be helpful.

上尿路梗阻是肾后性急性肾功能衰竭的主要原因，如能明确是结石引起的肾后性肾功能衰竭，应首选输尿管镜下钬激光碎石并置管引流；如不能明确，膀胱镜下逆行插管和经皮肾穿刺造瘘引流也是可行的急诊有效方法。

Although several neurophysiological alterations have been associated with autism, immune abnormalities and neural hypoperfusion appear to be broadly consistent.

尽管自闭症伴会随有许多神经生理学上的改变，但更多的变化是免疫异常和神经系统的组织灌流不足。

The decreased function of Leydig cells and damage of ECM in testis during experimental orchiditis might be the factors associated with the poor fertile ability.

发生睾丸炎期间，睾丸间质细胞功能下降，睾丸内细胞外基质受损，这可能是导致生育力下降的原因之一。

Osteolysis is believed be caused by the host's response to particulate wear debris associated with cement failure and subsequent loosening of the prosthesis.

骨溶解相信是由于宿主对骨水泥失败相关的磨损微粒的反应和随之的假体松动而引起的。

Our studies indicate that the increased contents of glucose and accumulation of active metabolic intermediates due to metaboic disorder contribute to the cutaneous environmental alterations associated with diabetes mellitus.Thus,the cutaneous environmental alteration is one of the initial events for impaired healing.The succession of progressive injury in deep partial thickness burn wounds is carried out depending on the physiological outcome of parabiotic tissues.The loss of dernal template due to the damage to the integrity and the continuity of dermal tissue may be one of the leading reasons of hyperplastic scar formation.

通过对糖尿病合并创面难愈、烧伤创面的进行性损害以及增生性瘢痕形成的机制研究，我们发现：糖尿病代谢紊乱所致皮肤组织中糖含量增高和代谢产物蓄积引起的皮肤微环境改变，是导致糖尿病创面难愈的始动因素之一；烧伤后的组织进行性损害的发生发展取决于&间生态&组织的病理转归；真皮组织缺损导致的模板作用缺失可能是引起增生性瘢痕形成的始动环节。

Down-regulated expression of PTEN and up-regulated expression of VEGF〓 were considered as two important events in tumorigenesis of ovarian cancer and could act as molecular markers to indicate the pathobiological behaviors of ovarian cancer. Decreased PTEN expression and increased VEGF〓 expression were closely associated with tumorigenesis and pathobiological behaviors of ovarian endometrioid and serous cancer respectively. Reduced expression of PTEN gene might be involved in carcinogenesis and progression of ovarian cancer by up-regulating the VEGF〓 expression to enhance angiogenesis.

在卵巢癌组织中PTEN基因mRNA表达下调和VEGF〓基因mRNA表达上调是卵巢癌发生的重要分子事件，可作为反映卵巢癌病理生物学行为的指标，且分别与卵巢内膜样癌和浆液性囊腺癌的发生和病理生物学行为关系密切；PTEN基因mRNA表达降低可能通过上调VEGF〓基因mRNA表达促进新生血管形成，进而参与卵巢癌的发生和侵袭。

The prehistorical sculpture-a woman touching herself on her breasts and belly shows that our prohistorical ancestors' idea of sculpture was closely associated with the instinctive human nature;The encient Egyption human sculptures have hardly ever changed,and remained the same for almost 3000 years,which reflects that the encient people believed their belief would last as long as forever,and the distinctive taste of their works;The Buddist sculptures are the tool for the religion to express it's idea. While,the encient Geece artist were seeking the hamoney and balance of human movement,which can be found easily in their works.

从史前女体雕刻的姿势多为抚腹或抱胸可以看出原始人雕塑的观念直接与生命的本能联系在一起；古埃及漫长的三千年历史中人像雕刻的姿势都没有明显变化，反映了当时人们坚持自己的信仰永恒的态度，及其艺术法则的独特风格；佛教造像把人物姿势做为传达教义的解说词；古希腊的人物雕塑的姿势体现了他们对和谐。

Removal of spinal implants, even in the face of what appears to be a solid fusion at exploration, is sometimes associated with progression of deformity.9 The retention of implants in the setting of a delayed infection is enticing to the deformity surgeon, especially when a pseudarthrosis is present.

即使在探查时发现脊柱已经牢固融合时取出植入的内固定物，有时还会导致脊柱畸形的进行性发展。在迟发性感染的患者身上保留植入物对医生来说是很有诱惑性的，特别是在出现假关节的时候。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。