查询词典 azole

:To study the relation between Fluconazole -resistance mechanism of Candida albicans with mutation in ERG11 gene, and determine the mechanism of drug-resistance to azole in Candida albicans.

摘要探讨白假丝酵母菌靶酶编码基因(ERG11)突变与氟康唑耐药性的关系，以分析白假丝酵母菌对唑类药物耐药机制。

In the present study, we examined the large-scale gene expression profiles with six sets of matched clinical and experimental fluconazole susceptible and resistant C. albicans strains by microarray analysis. We observed that azole resistances developed in multiple circumstances are all associated with increased expression of CDR mRNA. We also identified some common differential expressed genes and some interesting function-linked gene groups involved in drug-resistance.

利用所构建的基因芯片我们研究了共六对氟康唑敏感和耐药白念珠菌配对菌株的大规模基因表达谱，证实不同环境下产生的白念珠菌耐药性均与多药耐药基因CDR的mRNA表达增加有关，并从中鉴定了一些与药物耐受性相关的共同差异表达基因和一些有趣的功能连锁基因群。

Azole resistance was found in the candida albicans isolate from the renal transplant recipients, and there is no connection between incidence of resistance and isolate locus.

通过PCR扩增该基因上游启动子调控序列，转化质粒扩增后测序未找到耐药/敏感菌株在调控序列上的任何点突变。

The new product development the project administration developing a project the head beautiful spore azole sodium powder needle for enterprise applies is carried out has accumulated precious experience, that enterprise will take this as turning point in new product development the days to come project, has made the new product development project administration step by step perfect and the science giving has extended application.

头孢美唑钠粉针开发项目为企业应用项目管理进行新产品开发积累了宝贵的经验，企业在今后新产品开发项目中将以此为契机，使新产品开发项目管理逐步完善并科学的加以推广应用。

Radioimmunologic method was used to evaluate the influence of th e complex prescription of regulating the spleen and stomach on the pentylenetetr azole kindled rats and changes of the opioid peptides concentration in th e brain.

为了研究调理脾胃复方的抗痫作用，本实验采用放免法观察大鼠PTZ点燃以及服用调理脾胃复方治疗后，脑内阿片肽含量的变化。

And according the results of the fluconazole sensitivity, differential expression level of CDR1 mRNA was showed on the candida albicans azole resistance and sensitive isolates, we want to discover the molecular mechanism of CDR1 expression regulation by detecting whether there were the mutations on the upper stream of the CDR1 gene.

CDR1基因在白念珠菌唑类耐药/敏感菌株中的表达情况观察，对念珠菌的mRNA进行NORTHERN BLOT检查，发现唑类耐药株与敏感株在CDR1基因表达上存在显著差异。3。

And according the results of the fluconazole sensitivity, differential expression level of CDRl mRNA was showed on the Candida albicans azole resistance and sensitive isolates, we want to discover the molecular mechanism of CDRl expression regulation by detecting whether there were the mutations on the upper stream of the CDRl gene.

CDRI基因在白念珠菌哇类耐药／敏感菌株中的表达情况观察，对念珠菌的mRNA进行NORTHERN BLOT检查，发现哇类耐药株与敏感株在CDRI基因表达上存在显著差异。3。

The studies presented here provided the antifungal lead compounds. Because the affinity of the lead molecules for CYP51 was mainly attributed to their nonbonding interaction with the apoprotein, which was different from the azole antifungal agents.

先导分子通过与靶酶活性腔氨基酸残基的非共价键结合产生抗真菌作用，避免与血红素辅基Fe原子发生配位结合，为一类具有新作用机理的非氮唑类抗真菌先导化合物。

The synthesis methods of energetic salts and energetic ionic liquids(cations including triazole, tetrazole, bridged azole, hexamethyenetetrammonia, etc;and anions including nitrate, perchlorate, azide, tetranitratealuminate, polycyan anion, N,N'-dinitrourea, etc.) are reviewed, and the effects of cations, anions and their substitution groups on melting point, enthalpy of formation, density of the materials are summarized.

本文综述了多种含能盐和含能离子液体（阳离子包括三唑、四唑、双环唑、六次甲基四胺等；阴离子包括硝酸根、高氯酸根、硝基唑、叠氮根、四硝基铝、多腈基化合物、二硝基尿素等）的合成；结合其表征结果分析了阳离子上的取代基以及阴阳离子对它们的性能如熔点、生成焓、密度等的影响。

The azole drugs including fluconazole target lanosterol 14α-demethylase, the product of the ERG11 gene. Ergllp is one of the enzymes in the biosynthesis of ergosterol, the major sterol of fungal membranes and an analogue of cholesterol in mammalian systems.

唑类药物外流也是导致唑类耐药的主要原因，而与之药物外流泵相关的基因有ATP结合盒转运子基因(ATP Binding Cassette Transporter)——CDR1、CDR2和主要易化子基因——MDR1、FLU1，他们的过度表达可以导致唑类耐药的发生。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。