查询词典 autophagy

Critically, the combination of a tyrosine kinase inhibitor, i.e., IM, nilotinib, or dasatinib, with inhibitors of autophagy resulted in near complete elimination of phenotypically and functionally defined CML stem cells.

关键的是，联合应用酪氨酸激酶抑制剂，如IM、尼洛替尼、达沙替尼和自噬抑制剂可几近全部消除表型及功能定义的CML干细胞。

In this review, we focus on such protein conformational disorders and on the role that altered function of intracellular proteolytic systems, in particular autophagy, plays in the evolution of these diseases.

在这回顾中，我们集中在上述的蛋白质的构象无序和细胞内的蛋白水解系统功能改变的作用，特别自噬，在疾病演变的作用。

Autophagy, appears to involve an active participation of the vacuolar membranes.

自体吞噬似乎与液泡膜的积极参加有关。

Autophagy and apoptosis mightaccelerate activation of lysosomal enzyme and formation of secondary lysosome.

自噬和凋亡促进了溶酶体酶的活化及次级溶酶体形成。5。

Autophagy is an important process in which preformed lysosomes process endogenous substrates in cells.

自噬是发生在细胞中由初级溶酶体处理内源性底物的重要过程。

Autophagy is a process in which the subcellular membrane structures undergo dynamic morphological changes that lead to degradation of cellular proteins and organelles by lysosomes.

自噬是亚细胞膜结构发生动态变化并经溶酶体介导对细胞内蛋白质和细胞器降解的过程。

Thus, we have demonstrated proof of principle for a new approach for discovery of small-molecule modulators of mammalian autophagy.

这样，我们已经表明了一种新方法的根本证据，这种方法发现了恒温动物自我吞噬的小分子调节器。

Here we show that a primary small-molecule screen in yeast yields novel small-molecule modulators of mammalian autophagy.

我们说明一个酵母产生的原始小分子片断为新的小分子哺乳动物自噬调节剂。

LC3-FITC had been used to monitor autophagy by immunofluorescence. It showed that there are a high level of LC3 puncta in HCQ+DOX or BAF +DOX treated cells, and in rapamycin treated cells, moderate level in HCQ, BAF, or DOX singly treated cells, and low level in 3-MA+DOX, and there was diffuse fluorescence in untreated or 3-MA treated cells.

内源性LC3免疫荧光染色显示，羟氯喹+阿霉素、BAF+阿霉素及雷帕霉素处理组MM细胞胞浆可见大量颗粒状荧光，羟氯喹、BAF、阿霉素单用组仅有中等量颗粒状荧光，而3-MA及3-MA+阿霉素组胞浆荧光信号基本呈弥散分布，类似于未处理对照组。5。

Through a second process known as autophagy, or "self-eating," nerve cells are able to defend against the toxic effects of aggregated forms of mutant huntingtin and ataxin-1 that have escaped the surveillance of the ubiquitin proteasome system.

通过称之为自噬或者自食的第二个过程，神经细胞能够防御那些逃避过泛素-蛋白酶体系统监视的突变亨廷顿蛋白和ataxin-1引起的毒性作用。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。