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No matter how time of gobble up everything, we want at this alive of time, try to gain our good reputations hard, can't make the horary sickle hurt us.

1-29、不管饕餮的时间怎样吞噬着一切，我们要在这一息尚存的时候，努力博取我们的声誉，使时间的镰刀不能伤害我们。

Kerri's post on volunteerism reminded me of a decision we made round here to have an open door policy. Any time, any day; we're usually cool with guests. While pretty much all of our friends are at least "short-notice" kind of people, no notice is fine too… though you obviously take the chance that we're not home. If it's meal time, there is usually more than enough to go around; if not, you're welcome to rummage through the fridge.

可妮的志愿服务提醒我做开放式政策的决定，任何时候，任何一天，过去我们经常很冷漠地对待客人，然而相当多的我们的朋友至少可以短暂的友善对待，当我们不在家的时候，你没有注意他们也没有关系，如果这是吃饭的时间，这将会有足够的时间来关注，如果不的话，通过冰箱里的食物你也会发现你搜寻东西也是受欢迎的。

On the basis of these treatments, the patients in the treatment group also had aerobic kinesitherapy through limb and trunk exercises with assistance to improve oxygen consumption of the body and increase the heart rate. In each session of exercise, the patients were supposed to attain the target heart rate of 70％ to 85％ of the personal highest safe heart rate.At the beginning, each session of exercise lasted for 10-15 minutes and the heart rate or pulse was measured every 4-6 minutes, with the patients'heart rate allowed to increase by no more than 20/minute and the patients not feeling tired. The subsequent exercise time gradually increased but not over 30-40 minutes, twice a day for no less than 5 days a week.

干预：两组患者均给予改善循环和营养神经药物等治疗，在此基础上，治疗组采用有氧运动疗法：以靶心率为指标，即以通过运动获得的个人最高安全心率70％～85％作为每次运动的靶心率，开始时每次运动10～15 min，每运动4～6 min测一次心率或脉搏，运动以患者心率增加不超过20次/min、患者感觉不疲乏为度，以后逐渐增加运动时间，直至每次活动持续时间30-40 min，2次/d，每周治疗不少于5 d。

The time of awake and extubation from stop pumping remifentanil and side-effect such as respiratory depression, laryngospasm, crying, nausea and vomiting at recovery were recorded.results:there was no significant difference in the time of awake and extubation between the two groups.

观察并记录两组麻醉诱导及维持期bp、hr、spo2、术毕停药至气管拔管时间、苏醒时间及苏醒期呼吸抑制、喉痉挛、躁动或哭闹、恶心呕吐等不良反应。

PPAR γ agonist displayed obvious renoprotective action,the mechanism was complicated, it could improve the metabolism of glucose ang lipid, depress blood preasure, protect small vessels endothelium,improve the system activity of blood clotting and fibronolysis, antiinflammation, otherwise the action was more obvious with the time passed, at the early stage the effective was better,so encourage the patients to take the medicine earily; when the patients with the mediate reanl function failure, Avandia did not display significantly renoprotective action, side reaction had no difference compared to the control group,was not necessary to regulate the dose of Avandia.But because of the sample size was small, we needed a biger sample to confirm the results. We confirmed that Prol2Ala had no difference in control case,diabetic nephropathy group and diabete group,In diabetic group and diabetic nephropathy group, Ala carriers compared to noncarrier all kinds of biochemical indicators were not different,Prol2Ala did not have association with diabete and diabetic nephropathy. But because of the sample size was small, weneeded a biger sample to confirm the results.

PPARγ激动剂对糖尿病肾病具有明显的保护作用，保护作用的机制是多方面的，除了改善糖脂代谢，降低血压外，还具有保护小血管内皮，改善凝血和纤溶系统活性，抗炎症等多方面的作用，且作用随着用药时间的延长而日趋明显，在疾病的早期应用效果更佳，故提倡早期用药；对伴有慢性肾功不全的患者，罗格列酮对肾脏靶器官的保护作用显现的并不明显，但副作用与对照组无明显差异，不用根据肾功情况调整用药，但由于样本量较小，上述结论尚需大样本进行进一步证实；本实验研究得出Prol2Ala变异在健康对照组、糖尿病组及糖尿病肾病组均无显著差异，糖尿病组及糖尿病肾病组临床各生化指标与Prol2Ala变异亦无相关性，Prol2Ala与糖尿病及糖尿病肾病不相关。

In nonsmokers without pulmonary disease at baseline, there were no severe decreases in lung function attributed to Exubera, and high-resolution chest computed tomography revealed no evidence of notable lung changes. Completed phase 2 and 3 studies that followed patients for up to 4 years indicate that the differences over time in pulmonary function changes between patients treated with Exubera and control patients are small, nonprogressive, clinically insignificant, and reverse after discontinuation of Exubera therapy.

Feb。 9， 2006 --尽管一开始对於肺功能影响的顾虑，美国食品药物管理局仍然批准辉瑞药厂生产的吸入性胰岛素Exubera使用於成人第1、2型糖尿病；该核准案於1月27日通过，也就是欧盟核准该药物上市后隔天；自从胰岛素於1920年代被发现以来，吸入型粉状的基因重组人类胰岛素是第一个新的胰岛素投与选择；临床试验数据显示，使用exubera一开始会使肺功能下降，但是并非进行性的，其效果与一般胰岛素相当，而且具有病患顺从性较高的优点。

The most of the product became soluble from inclusion body by lowering induction temperature. At the same time the gene was cloned into vector pMAL-p2X, which was translated in E. coli TB1 and expressed a fusion protein. We optimized the induction time and achieved high expression. But there was no obvious product secreted in the periplasm extract. Almost all fusion protein is expressed soluble in cytoplasm.

利用融合型表达载体pTYB11-EFE融合型表达，对诱导剂IPTG的浓度和诱导温度进行了优化，通过降低诱导温度使产物由包含体变成可溶性融合型产物；利用融合型分泌表达载体pMAL-p2X构建了表达载体pMAL-p2X-EFE-7~#，对诱导时间进行了优化，获得了较高的表达量，但发现产物没有明显的分泌表达，绝大部分是以可溶形式存在于胞内。

Result: Y-BOCS scores improved significantly over time in two drug-nave patients and a patient with combination treatment. There was no significant improvement in Y-BOCS scores in patients who failed more than 2 standard treatments with SRIs. For responders, the time intervals to achieve criteria of response (more than 35% decrease of Y-BOCS scores) were within 2 weeks of sarcosine treatment at relatively low dose.

在使用过或维持SRIs治疗之个案，sarcosine之疗效则不一致：并用SRIs治疗四位中，两位血清素回收抑制剂顽抗型(SRIs-refractory)个案对sarcosine无明显疗效；另一位并SRI治疗个案在用药两周内强迫症状即有明显改善，但在服药剂量减少两周后症状恶化。

Weather is now included in the game, with rain causing the ball to slow up as you hit it over a sludgy surface, but in Manager Mode every game is played at the same time of day in the same weather conditions - there are no night games and no rain/snow games.

天气现在是包括在这场比赛中，有雨造成球慢了你击出了泥的表面，但在管理模式是每场比赛在同一时间在同一气候条件-有没有夜间比赛和无雨/雪比赛。

When I got to where I found the boy I see I couldn't cut the bullet out without some help, and he warn't in no condition for me to leave to go and get help; and he got a little worse and a little worse, and after a long time he went out of his head, and wouldn't let me come a-nigh him any more, and said if I chalked his raft he'd kill me, and no end of wild foolishness like that, and I see I couldn't do anything at all with him; so I says, I got to have HELP somehow; and the minute I says it out crawls this nigger from somewheres and says he'll help, and he done it, too, and done it very well.

我一到那个孩子所在的地方，发现非有一个助手不可，不然，我就无法把子弹取出来。按当时的情况，我无法离开，到别处去找个帮手。病人的病情越来越糟。又过了一段时间，他神志不清了，又不允许我靠近他身边。要是我用粉笔给木筏子上写下记号，他就要杀死我。他这类傻事几乎没有个完，我简直给弄得束手无策。所以我对自个儿说，我非得有个助手不可，怎么说也非有不可。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。