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"Our observations, combined with those of others, suggest that widespread axonal dysfunction is associated with fatigue in MS," write Maria Carmela Tartaglia, BSc, MD, from Montreal Neurological Institute and Hospital in Quebec, Canada, and colleagues."It may be hypothesized that diffuse white matter disease translates into an increase in the central nervous system effort required by a patient with MS to perform the same activity as compared with a disease-free subject, with resultant fatigue."

来自加拿大魁北克医院及蒙特娄神经学学会的Maria Carmela Tartaglia博士和其同僚表示，他们的观察结合了其他人的之后建议，多发性硬化症患者的疲劳症状和广泛性轴突功能障碍和有密切关联，其可被假设为为当多发性硬化症患者在和其他正常人做同一活动时，其弥漫性白质疾病导致中枢神经做功增加，而产生较疲劳的结果。

Results:50 patients with lesions associated with anterior descending artery was 35,and the right coronary artery 19,circumflex 10.26 patients with single-vessel disease,18 patients with double-vessel disease,and three lesions 6,the survival rate of PCI is 98%.we follow up from 6 to 40 months after surgery,Chest pain occurred again in 7 patients, 3 patients performed PCI, and 1 case had stent obstruction,1 case died of AMI.

结果：50例病变相关动脉为前降支35处，右冠状动脉19处，回旋支10处。单支病变26例，双支病变18例，三支病变6例；PCI成功率98%；术后随访6～40个月，7例再次出现胸痛发作，3例患者行PCI术，其中1例为原有支架闭塞；急性心肌梗死死亡1例，为心肌梗死后心功能衰竭。

Results: Compared with women of illiberality those who accepted education had lower risk of cervical erosion, with ORs of 0.505, 0.397 and 0.404 for primary school, junior middle school and senior middle school respectively. The delivery at home increased the risk (OR=1.65) compared with delivery in hospital. The marriage age was associated with the risk and the ORs were 0.53 and 0.59 for 23~24 years and ≥25 years compared with ≤22 years.

结果：农村已婚育龄妇女宫颈糜烂患病的危险因素中，学历以文盲为基线，小学、初中、高中的OR分别为0.505、0.397与0.404；在医院分娩为基线，家中分娩的OR为1.65；初婚年龄以≤22岁为基线，23~24岁、≥25岁的OR分别为0.53、0.59。

Thus Indra, the chief of the gods, was regarded as the regent of the east; Agni, the fire, was in the same way associated with the southeast; Yama with the south; Surya, the sun, with the southwest; Varuna, originally the representative of the all-embracing heaven, now the god of the ocean, with the west; Vayu, the wind, with the northwest; Kubera, the god of wealth, with the north; and Soma with the northeast.

从而因陀罗，众神之主，被认为是东方的摄政者。

The category is designed to include a group of children with severe mental retardation (IQ below 50) who show major problems in hyperactivity and in attention, as well as stereotyped behaviours. They tend not to benefit from stimulant drugs (unlike those with an IQ in the normal range) and may exhibit a severe dysphoric reaction (sometimes with psychomotor retardation) when given stimulants. In adolescence, the overactivity tends to be replaced by underactivity (a pattern that is not usual in hyperkinetic children with normal intelligence). This syndrome is also often associated with a variety of developmental delays, either specific or global.

因有下述特徵则作此诊断：出现注意力不集中及过动行为的重度智能不足（智商低於 50 ）；给予兴奋性药物治疗并不能改善此类儿童的情况，反而可能会有情绪低落反应在少年期少动行为常取代过动行为（这种情况在正常智商的过动儿童并不常见），同时常并发特定或全面的发展迟滞。

Methods :25 cases of traumatic hydrocephalus were analysed retrospectively.Among them,3 cases showed brain contusion,4 with subrarchnoid hemorrhage,5 with subdural effusion,2 with epidural hematoma,1 with subdural hematoma,1 with fracture of skull,3 with malacia lesions,3 with cerebral infarction,and 2 with cerebral hernia.The other 3 cases were not associated,with intracranial traumatic anomaly.

回顾分析25例外伤性脑积水，其中分别伴颅脑损伤有3例脑挫伤、4例蛛网膜下腔出血、5例硬膜下积液、1例颅骨骨折、3例脑内软化灶、3例脑梗塞、2例硬膜外血肿、1例硬膜下血肿、2例脑疝(大脑镰下疝及钩回疝各1例)，另3例颅内未见外伤性异常改变与其并存。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

The results indicated that the fragments (HF3～HF8) with higher MW (≥3000) but not those (HF1, HF2) with lower MW (＜3000) had effects on CFU-MK growth. Moreover, HF3～HF8 could act synergically with TPO(10ng/ml) in promoting CFU-MK growth, but HF1, HF2couldnot. In addition, there were no differences in the effects ofHF3～HF8 on CFU-MK growth, suggesting that the synergy of heparin with TPO was associated with its MW, but not its sulfate content or activity of anticoagulation.

结果表明分子量较小的HF1和HF2(＜3000)没有促进CFU-MK生长作用，而分子两较大的HF3～HF8具有促进作用，并且前2者没有协同TPO(10ng/ml)的作用，后6者都有协同作用，后6者之间的作用比较没有差异，提示肝素协同TPO的作用与其分子量有关，而与硫酸基团含量和抗凝活性无关。

Method］from sept 2001 to feb 2005, 13 knees with combined acl and pcl tear in 13 patients were verified with arthroscopy. of them, 5 knee were combined with rupture of the posteromedial coner and medial collateral ligament, 3 combined with disruption of the posterolateral corner, 2 with lateral meniscus tear, 1 with medial meniscus tear, 3 associated with popliteal vascular injury and 2 with peroneal nerve injury. seven patients were admitted into this department in acute phase of trauma, repair of popliteal artery in 2 patients and repair of pmc and mcl in 4 patients were performed in this phase. arthroscopic combined reconstruction of acl and pcl with autografts was performed in all patients from 4 to 12 weeks after trauma, reconstruction of plc with the posterior half of biceps femoris tendon tenodesis in 3 patients and reconstruction of pmc and mcl with femoral fascia in 1 patient were completed simultaneously.

方法］自2001年9月~2005年2月，13例病人（13膝）经关节镜检查证实acl和pcl均断裂，其中5膝伴后内侧角、内侧副韧带损伤，4膝伴后外侧角损伤，2膝伴外侧半月板破裂，1膝伴内侧半月板损伤，3膝伴动脉损伤，2膝伴腓总神经损伤。7例病人于损伤后急性期入院，2膝于急性期行血管探查修复，4膝行膝后内侧角、内侧副韧带修复。13例病人于伤后4~12周在关节镜下行自体移植物单束acl和pcl联合重建术，其中4例同期后1/2 股二头肌腱重建后plc，1例同期阔筋膜pmc、mcl重建。

Evidence suggests that 1 under more stable stratification, the basic flow, if moving faster at low and high levels (particularly in the presence of jets there), allows a resulting meso-β unsteady wave to propagate eastward with respect to basic flow and even at greater velocity compared with it; 2 vertical windspeed shear of basic flow causes instabilities of the TWT perturbation; 3 considering the second derivative of basic-flow wind with respect to z (denoted by zz≠ 0 which is simply given as β* hereafter) the expression for the phase velocity of vortex Rossby wave is obtained, which is unidirectional in propagation with respect to basic flow; 4 VRoW has its physical origin from β*, i.e., from z-varying heterogeneities of y-direction averaged vorticity of the basic flow field; 5 VRoW phase velocity is associated with zonal wave number k, its energy is dispersive and the group velocity exists in the x direction; 6 when windspeed meets the condition of β*, TWT disturbance instability may be that of mixed VRoW and gravity wave; 7 if basic flow is subject to linear shear but does not meet the condition of β*, the TWT instability is that of inertia-gravity wave.

在大气层结比较稳定的情况下，如果基本气流在低层和高层较大(有可能存在低空急流和高空急流)，此时产生的β中尺度不稳定扰动相对于基流向东传播，甚至于快速向东传播。基本气流在垂直方向上的风速切变对于中尺度横波型的扰动起着不稳定的作用。如果考虑基流的二次切变，可以得到涡旋Rossby波的相速度表达式，涡旋Rossby波相对于基本气流是单向传播的。涡旋Rossby波产生的物理根源是基本流场的风速二次切变，亦即基本流场y方向的平均涡度在空间z方向上的不均匀所致。涡旋Rossby波的相速度与纬向波数也有关，它的能量是频散的，其在纬向x方向也存在群速度。在基本流场的风速存在二次切变时，横波型不稳定可能是混合的涡旋Rossby重力波的不稳定；而在基本流场的风速仅仅存在线性切变，不存在二次切变时，横波型扰动的不稳定则是重力惯性波的不稳定。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。