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The results showed that there were inadaptive responses,and there were significant differences (P＜0.01) among all levels. There were less inadaptive responses in the secondary nursing students than in the baccalaureate standard(P＜0.05) and college nursing students (P＜0.05); The Basic Physiologic Needs and the Role Mastery were not significantly difference among different level nursing students (P＞0.05); The difference in the self-Concept and in the interdependence was significant (P＜0.01). There were less inadaptive responses in the secondary nursing students than the BSN(P＜0.05) and college nursing students (P＜0.05) in the Self-concept; there were more inadaptive responses in the BSN than that in the college (P＜0.05) and secondary(P＜0.01) nursing students,and the difference was not significant among the college nursing students and secondary nursing students in the Interdependence.

结果表明：不同层次护生在毕业实习期均存在不适应反应，不同学历间有显著差异（P＜0.01），中专护生不适应反应少于本科（P＜0.05）及大专护生（P＜0.05），在生理需要及角色功能方面，不同学历间无显著性差异（P＞0.05），在自我概念方面，不同学历间存在显著性差异（P＜0.01），中专护生少于本科（P＜0.01）及大专（P＜0.05）护生，在互相依赖方面，不同学历间存在显著性差异（P＜0.01），本科护生多于大专（P＜0.05）及中专（P＜0.01）护生，大专与中专护生间无显著性差异（P＞0.05）。

There were eight strains in Group1 whose hosts were Indigofera, the central strain was SHLO42. There were six strains in Group2 whose hosts were diversity, the central strain was SH199. There were night strains in Group3 which major hosts were Astragalus , the central strain was SH290B.

第1亚群有8株菌寄主均为木蓝属的不同种，中心菌株为 SHL042；第2亚群有6株菌，寄主来源多样，中心菌株为 SH199；第3亚群9株菌，寄主大多数为黄芪属的不同种，中心菌株为 SH290B ；第4亚群7株菌，寄主很集中均为鸡眼草，中心菌株为 SH714；第5亚群菌株数较少仅有4株。

Results: a In the negative control group, spontaneous chromosome aberration and micronucleus rated the mice's were very low; in the positive control group, chromosome aberration and micronucleus rate of the mice's were highest. b Before cyclophosphamide intoxation, when the four kinds of vegetables and hilts juice were preventively irrigated into the mice's stomachs respectively, the chromosome aberration and micronucleus rate in the negative control group were lower than these in the positive control group (P.05); but after intoxation, when the four kinds of vegetables and fruits juice were therapeutically irrigated into the mice's stomachs respectively, the chromosome aberration and micronucleus rate were similar with the result above mentioned . c Acing the four kinds of vegetables and fruits, sea-buckthorn lad the best preventive and curative effects.

结果：a在阴性对照组中，小鼠自发的染色体畸变率和微核率极低；在阳性对照组中，小鼠染色体畸变率和微核率最高。b在环磷酰胺染毒之前，分别将4种蔬菜水果汁给小鼠进行预防性灌胃，其染色体畸变率和微核率均比阳性对照组低(P.05)；在染毒之后，分别将4种蔬菜水果给小鼠治疗性灌胃，其结果与上述实验结果相似。c在4种蔬菜水果中，以沙棘的预防和治疗效果为最好。

We introduced improved primary mixed glial culture and different-attachment method to isolate and purify the OPCs, the cells were proliferated in serum-free medium, flow cytometry and immunohischemistry methods were employed to estimate the purity of cultured OPCs. Their abilities of differentiation and expression of trophic factors were identified by RT-PCR and immunostaining. Several methods including TUNEL and MTT were adopted to estimate the protective effects of conditioned culture medium from oligodendrocyte lineage cells on the primary cultured cerebellar granule neurons. Intravitreal transplant of OPCs, combined with retrograde fluorescent labeling the superior colliculus and intraorbital optic nerve transection, were used to investigate the protective effects of OPCs on the axotomized RGCs in vivo. Intravitreal transplantof OPCs or NSCs on the newborn rats, and retinal transplant of OPCs on the young rats were performed, to observe the myelin formation in the retina at different stages after cellular transplantation. Optic nerve transection was carried out on some rats with myelinated retinae, to study the influence of myelination on the injuried RGCs.

为此，本研究采用改良的胶质细胞混合培养与差速贴壁方法获得大鼠OPCs，使用无血清培养基进行扩增、培养，用免疫组织化学和流式细胞技术对培养细胞的纯度进行鉴定，对少突胶质系细胞表达部分营养因子的情况进行检测；采用TUNEL、MTT等方法对少突胶质系细胞条件培养基对原代培养小脑颗粒神经元的保护作用进行检测；将OPCs移植入成年SD大鼠玻璃体内，利用上丘逆行荧光标记技术，观察眼内移植的OPCs对眶内视神经切断时的视网膜神经节细胞的保护作用及其持续时间；将OPCs或NSCs移植入新生和幼年SD大鼠玻璃体或视网膜内，观察不同时期视网膜内髓鞘形成与分布特点，分析髓鞘的超微结构，并观察眼内髓鞘形成对损伤神经节细胞的保护作用。

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

Results In 54 patients, 43 cases showed the masses with the first symptom, the percentage of which was 79.6%. The rate of stage II ~ III ( including 44cases) was 81.5%. The rate of 32 cases with accompanied diseases was 59.3%. 38 cases were breast cancer modified tradical mastectomy (70.3%), 12 cases were mammectomy(22.2%), 4 cases were partial mammectomy(7.4%). 23 cases were post-operation chemotherapy(42.6%), 12 cases were radiotherapy(22.2%), 43cases were Endocrine therapy(79.6%).

结果 54例患者中，以肿块为首发症状的有43例，占79.6%，Ⅱ～Ⅲ期病例44例，占81.5%，32例同时存在伴随疾病，占59.3%，其中行改良根治术38例(70.3%)，单纯乳房切除术12例(22.2%)，乳房部分切除术4例(占7.4%)，术后化疗23例(42.6%)，放疗12例(22.2%)，内分泌治疗43例(79.6%)，无手术死亡。

Results Women were more often affected than men(1.83:1) and 53 patients were older than 40 years. The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1：1.83，40岁以上发病53例，受累部位依次为眼睑58例（89.2%）、口-下颌46例（70.8%）、颈部17例（26.2%）；首发症状以眼部不适、眼睑痉挛最多（42例，占64.6%），口-下颌肌张力障碍次之（17例，占26.2%）；14例行头MRI检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。

After 24 hours, all rats were anesthetized again and their left common carotid arteries were cannulated to facilitate blood withdrawal for serum sample. The contents of tumor necrosis factor-a and interleukin-6 (IL-6) in serum were determined before and after experiment by ELISA; the activity of superoxide dismutase and content of malondialdehyde were determined by xanthinoxidanse method and modified TBA microdetermination. The content of NO2(superscript -)/NO3(superscript -), and activity of nitric oxide synthase and inducible NOS were determined by nitrate reductase method, and chemical chromogenic reaction, respectively; the immunoglobulin G, IgA, IgM and complement 3 (C3) and C4 were determined by immunoprecipitation method before and after experiment.

实验评估：手术创伤后24h进行采用酶联免疫吸附法测定实验前后血清肿瘤坏死因子α、白细胞介素6含量；应用黄嘌呤氧化酶法测定超氧化物歧化酶活性、改良TBA微量法测定丙二醛水平；以硝酸还原酶法、化学显色法分别检测NO2/NO3浓度及一氧化氮合酶、诱导型一氧化氮合酶活胜；以免疫比浊法经全自动生化分析仪检测血清免疫球蛋白IgG、IgM、IgA及补体C3、C4含量。

In this article, three kinds of prealloy powder were developed by water atomization method. The base attribute, pattern, phase composition, differential thermal analysis of powder were researched. Sintered density, hardness, bend strength, Young's modulus were researched as hot pressed sintering temperature changing. By using abrasive wearing equipment upbuilt by the authors, the wear resistance were determined. Green-pressing density, simulated green-pressing strength and bonding momental of high frequency brazing were assayed. SEM corrosion structure and SEM appearance of fracture were observed.

本文采用水雾化法开发了三种预合金代钴粉末：对粉末的基本属性、形貌，粉末的相组成，粉末的差热性进行了分析研究；测定了它们的烧结密度、硬度、抗弯强度、弹性模量随热压烧结温度变化的规律；采用作者自行建立的磨料磨损试验方法，测定了它们的质量磨损百分率；测定了它们的冷压生坯密度、模拟生坯强度以及高频钎焊的结合力矩；观察了热压烧结SEM腐蚀组织和SEM断口形貌。

objective to study the ct diagnosis of ureteral calculus at the distal end of ureter.methods 82 cases of ureteral caculus were examined by ct scanning.all cases were proved by clinical therapeutic results.results ureteral calculuses were showed as high density image in ct scanning.the ct values of the ureteral calculuses less than 7.5mm in diameter were beyond 83hu.the detection rate by ct was 96.3%.in all the 82 cases,ureteral with calculuses were found dilated and 69 cases with nephrohydrosis.in 13 cases with no nephrohydrosis,caculuses less than 3.8 mm in diameter were found.conclusion ct is the most valuable way to diagnose ureteral calculus at the lower end of ureter.appropriate methods of ct scanning are essential.

目的 回顾性分析输尿管膀胱入口处结石的ct诊断结果，评价其ct检查的临床应用价值。方法分析82例输尿管膀胱入口处结石的ct检查结果，所有病例均经尿道排石证实。结果输尿管膀胱入口处结石具有特征性的ct表现，即圆形或枣核状钙化高密度影，结石直径＜7.5mm，ct值≥83hu，ct确诊率96.3%。82例均发现病侧输尿管增粗，69例发现病侧肾盂少量积水，肾盂未见积水的输尿管膀胱入口处结石13例，其结石直径＜3.8mm。结论 ct检查输尿管膀胱入口处结石具有准确、无创、直观等优点，是诊断输尿管膀胱入口处结石不可替代的检查方法。

But this is impossible, as long as it is engaging in a market economy, there are risks in any operation.

但是，这是不可能的，只要是搞市场经济，是有风险的任何行动。

We're on the same wavelength.

我们是同道中人。