查询词典 apod

The polymorphism of rs2280250 at the APOD locus may not be associated with schizophrenia in North Chinese Han population.

国外多项研究结果提示，APOD很可能是精神分裂症的标志物，而其基因变异导致APOD基因

SELF is an APOD wide initiative that will be rolled out in 2008 to managers with direct reports in order to enhance the leadership competencies of our business leaders.

课程简介 SELF是APOD全范围的行动，这将在2008年向全部有下属的管理人员铺开由此来改善业务领导者的领导能力。

These suggsest that ApoD is a nonspecific response to different oxidative stimuli and may be part of an antioxidant defense system.

对鼠NIH/3T3纤维原细胞暴露在H2O2、UV等氧化压力条件下的研究显示，体内的ApoD表达量呈现出一种剂量依赖性的升高。

Note: Astronomy lectures by an APOD editor are now available as a free podcast.

注：天文学讲座，由一apod编辑器，现已成为一个自由播客。

Can the eclectic brain trust of APOD readers make any progress?

横跨各行各业的APOD读者是否能对这本书的解读有所突破？

Study of ApoD has been largely focused on its expression and physiological function, and information regarding its genomic orgnization and regulatory elements is extremely limited.

目前，对ApoD的研究主要集中在基因表达、组织分布和生理功能上，对其包括调控区在内的基因组结构分析相对较少，而这对于深入阐明ApoD功能及其基因表达调控具有重要意义。

APOD creates an operating statementfor the first year.

APOD为第一年创建一个运行声明。

At present, studies about function of ApoD expressed in vitro are still very little. A concentration-dependent manner of inhibition rate scavenging of hydroxyl radical and prevention nicking of the supercoiled DNA by recombinant BbApoD suggests that BbApoD probably takes part in antioxidation process in vivo widely.

目前，利用体外表达的ApoD蛋白直接测定其功能作用的研究还很缺乏，BbApoD重组蛋白对体外Fenton体系产生的羟自由基的抑制作用以及对DNA氧化损伤保护作用的浓度依赖性变化暗示了文昌鱼ApoD蛋白很可能也参与了体内的抗氧化过程。

Results: ApoD was observed positively expressed in type2 astrocytes and oligodendrocytes from O2A lineage, while it was not expressed in type1 astrocytes from T1A lineage. Accordingly, we can verify the phenomenon found in the study of T1A and T2A gene different expression profile that ApoD mRNA was highly expressed in T2A and lowly expressed in T1A. Conclusion: It can be concluded that lipid metabolism related genes such as ApoD play important roles in the generation and differentiation of O2A lineage, which closely correlate with internal mechanism of lipid metabolism in the brain and myelogenesis.［Key words］astrocyte(T1A, T2A); oligodendrocyte; O2A lineage; apolipoproteinApoD

我们已采用基因芯片技术在mRNA水平研究两型星形胶质细胞的基因表达谱差异，发现ApoD在2型星形胶质细胞中差异高表达，故本文拟用激光共聚焦双重免疫荧光标记技术进一步在蛋白质水平观察ApoD在体外分化成熟的两型星形胶质细胞以及少突胶质细胞中的表达情况，以期为我们深入研究ApoD等脂代谢相关基因在脑内脂质代谢和神经髓鞘发育机制中所起的作用提供有用的实验依据，依此探讨胶质细胞发生和分化的信号机制。

In this study, the genomic structure and regulatory elements of ApoD from 10 representive species including protozoan, invertebrate, protochordate and vertebrate were analyzed and compared. The genomic structure of ApoD is less conserved in organisms from protostome to deuterostome invertebrates, while it is highly conserved among chordates including amphioxus and verebrates. All four conserved cysteine residues are present in amino acid sequence of deuterostome ApoDs, while there are only two cysteine residues in amino acid sequence of protostomes ApoD. Structure divergence between protostome and deuterostome ApoD proteins suggests their function difference. The majority of regulatory elements are present in nearly all organism ApoD genes ranging from unicellular protozoan to mammals, suggesting that ApoD plays a very fundamental role, and possesses a conserved regulatory mechanism. However, there also exist some specific regulatory elements, which are present only in certain species and may perform some special roles.ApoD mRNA expression in murine NIH/3T3 fibroblasts exposed to various stresses such as as hydrogen peroxide and UV light shows dose-dependent increase. And a fly homolog of ApoD, Glial Lazarillo, whose overexpression results in increased resistance to hyperoxia as well as a extension of lifespan under normoxia and resistance to starvation without altering lipid or protein content.

本文首先从生物信息学角度对分属于原生动物、无脊椎动物、头索动物和脊椎动物类群的10种动物ApoD的基因结构及调控区的调控元件进行分析及比较，发现：(1)ApoD基因外显子-内含子结构从原生动物草履虫到原口动物再到后口动物海胆的进化过程中不保守，但在分析的几种脊椎动物中相当保守；(2)文昌鱼ApoD基因扮演从无脊椎动物到脊椎动物承上启下的角色，可能代表了脊椎动物ApoD基因原型；(3)四个半胱氨酸保守位点在后口动物中都存在，而在原口动物中只存在两个，原口、后口动物ApoD蛋白一级结构上的差异反映蛋白功能上可能也存在一定差别；(4)调控区大多数主要调控元件为不同动物共有，说明ApoD主要功能及其表达调控在进化中相当保守；(5)ApoD基因个别调控元件是随着物种进化而出现并开始发挥相关作用，如SF-1；还有一些调控元件在进化过程中还没有发现其规律，这说明ApoD某些功能和基因表达调控模式可能因物种不同而存在一定的差异。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。