查询词典 antiepileptic

The effects of Caoguozhimu Decoction, a TCM antiepileptic, on NMDA receptor binding capacity and the expression of NMDAR1 mRNA in pentylene tetrazole-kindled rat model were observerd by the ligand-receptor method and i n situ hybridization, with MK-801 as a contrast.

观察抗癫痫中药草果知母汤在阻断戊四唑点燃模型形成过程中，对兴奋性氨基酸类神经递质Glu的受体NMDA结合力及其NMDAR1 mRNA的影响。以NMDA的竞争性拮抗剂MK- 801为对照，用配基受体法、原位杂交法检测相应指标的变化。

Methods To establish amygdala kindling models in rats and observe the effect of dizocilpine on kindling models and its combination with general antiepileptic drugs (phenobarbital, valproate and nicardipine) at ineffective dose. The influence of dizocilpine on convulsions induced by semicarbazide in mice were also observed.

方法建立大鼠杏仁核慢性电刺激点燃模型，测定不同剂量的MK-801对点燃模型各项指标的影响，探讨MK-801与其他抗癫痫药的协同作用，用氨基脲诱发的小鼠惊厥模型测定MK-801抗惊厥作用。

Topiramate,2,3:4,5-bis-O-(1-methyl-ethylidene-)-β-fructopyran -ose sulfamate , a novel antiepileptic drug, has been demonstrated to be effective in controlling a wide range of seizure types, including focal seizures, primary generalized tonic-clonic seizures and Lennox-Gastaut syndrome, among others.

托吡酯(topiramate，TPM)是一种新的抗癫癎药，其化学结构为2，3：4，5-双-O-(1-甲基亚乙基)-β-右旋-氨基磺酸吡喃果糖，在多种癫癎发作类型治疗中有效，包括局灶性癫癎发作、原发性强直阵挛发作、Lennox-Gastaut综合征等[1-2]。

Starting from tetrafuran, 2_(4_Aminosulfonylphenyl)_4H_1,2_thiazine_1_dioxide, an antiepileptic drug with special structure, was obtained via esterification, sulphonation, chloridization, condensation and cyclization.

以四氢呋喃为原料，经酯化、磺化、酰氯化、缩合、环化等步骤，合成了化学名为 4_(四氢_2H_1，2_噻嗪基_2 )苯磺酰胺_S_S_二氧化物的抗癫痫药舒噻嗪，通过IR、1HNMR和元素分析对其结构进行了表

One possible explanation for poor-quality sleep in individuals with epilepsy may be the tendency to have sedentary lifestyles and daytime sleepiness, effects that are frequently attributed to the sedating effects of antiepileptic drugs.

癫痫病患睡眠品质差的可能解释原因之一，是需要久坐的生活型态，与因抗癫痫药物所引起的镇静效果所致的昼间睡眠。

Results The age of the onset of symptoms ranged from 3 to 12 years. The clinical attacks lasted a variable time from 1 hour to more than 3 weeks. Definite medical causes were identified in 78% of the patients. Each patient had a prolonged change of consciousness, accompanied by psychological and behavioral changes. The characteristics of ictal EEG in CPSE patients generally included slow activity and δ or θ activity in the temporal region. After antiepileptic drug treatment, the conditions of 11 patients were under complete control, 4 patients had no CPSE but complex partial seizures, and 2 patients had no improvement.

结果 17例CPSE患儿起病年龄为3～12岁，临床发作持续时间为1 h～3.5周；78%的患儿有明确的病因，CPSE临床表现多样，所有病例均有意识障碍，同时伴有不同程度的精神和行为异常，发作期脑电图主要以基本电活动变慢伴颞部局灶性慢波或痫样放电的持续或周期性发放为特征，经抗癫痫药物等治疗，11例患儿持续发作完全控制，4例持续状态控制，仅有部分性发作，2例未能控制。

These results suggest that the prescription reciped based on the theory of the correlation between spleen-stomach and mentality can effectively hold back the epileptogenesis. The antiepileptic mechanism of the prescription may relate with reducing the release of monoamines; regulating the level of cAMP and cGMP and diminishing gene and protein expression of c-fos、c-jun.

本文研究结果提示，根据脾胃与神志相关理论，以调理脾胃为主旨组成的复方能有效阻抗PTZ点燃大鼠EP发作；其抗痫机理可能与减少单胺类神经递质的释放、调节cAMP、cGMP水平，进而削弱c-fos、c-jun基因及蛋白的表达有关。

Chromosomal abnormalities, single mutant genes, and maternal diabetes mellitus or ingestion of teratogens, such as antiepileptic drugs, are implicated in about 10% of the cases.

孕中期诊断无脑畸形基于颅顶和大脑半球缺乏，然而面骨、脑干和部分枕骨、中脑通常存在。大约50%的病例合并脊柱异常，早孕期，可在11周后做出诊断，因为此时，颅骨开始骨化。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。