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Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome

目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析，并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography，FFA)、吲哚青绿血管造影(indocyanine green angiography，ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例，73.5%)，双眼同时患病118例(80.8%)；后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%)；前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例，98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%)；后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障；毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现；炎症活动期FFA典型表现为斑驳状高荧光，ICGA发现脉络膜血管扩张、通透性增高等改变；VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎，随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。

The constant nutritional arteries of the great saphenous vein-saphenous nerve on the medial foot: Perforator at medial side of the tendon of the tibialis anterior ,it is （2.27±0.43）cm distal to the intermalleolar line .it passes across the medial side of the tendon of the tibialis anterior and pierces the deep fascia between the upper and lower bundle of the inferior extensor retinaculum with a diameter of （0.72±0.04）mm;The length of it after piercing the deep fascia is （7.3±0.6）mm,It has an emerging rate of 95%; Perforator between tendons ,it is （3.02±0.39）cm distal to the intermalleolar line;it pierces the deep fascia between the tendons of tibialis anterior and extensor digitorum longus with a diameter of (0.57±0.06)mm ;The length of it after piercing the deep fascia is （7.4±0.6）mm .It has an emerging rate of 94%; A constant distal fascial perforator pierces the deep fascia between abductor hallucis muscle and medial side of first metatarsal bone （1.97±0.23）mm distal to the first metatarsophalangeal joint with a diameter of (0.50±0.03)mm.

足内侧大隐静脉-隐神经营养血管近端来自内踝前动脉较为恒定，外径较大的穿支有：踝间线远端（2.27±0.43）cm，经胫骨前肌腱内侧、伸肌下支持带上、下束间穿出，外径(0.72±0.04)mm ，穿出深筋膜的长度为（7.3±0.6）mm，出现率为95%；踝间线远端（3.02±0.39）cm，经胫骨前肌腱与趾伸肌腱穿出，外径(0.57±0.06)mm，穿出深筋膜的长度为（7.4±1.2）mm ，出现率为94%；3远端来自交通支最为恒定，外径较大的穿支于踇展肌与第一跖骨内侧缘之间穿出深筋膜，距第一跖趾并节近端（1.97±0.23）cm，直径（0.50±0.03）mm，穿出深筋膜的长度为（6.5±0.5）mm，出现率为100%。

The anterior border of all flaps exceeded crista anterior fibulae, and that of 2 flaps reached to the crista anterior tibiae. The width of flap on anterial compartment of the cnemis ranged from 2.5cm to 7.0cm, averagely 4.0 cm.

行前界扩大的改良腓肠肌外侧头肌皮瓣21例，修复的创面位于小腿上1/3段9例，中1/3段前内侧7例，中1/3段前外侧5例。21例皮瓣前缘均超过腓骨前缘，其中2例达胫骨前嵴，位于小腿前骨筋膜室表面的皮瓣部分宽度为2.5~7.0 cm，平均4.0 cm。

METHODS: The distances from anterior acetabular margin, posterior acetabular margin to anterior inferior iliac spine, iliopubic eminence and pubic tubercle were measured, respectively to determine and make serial cross-sections of the acetabular anterior column. In addition, the safe angle of screw entry on all entry points of each cross-section was measured, and all data were put into software SPSS 10.0 for statistics process.

分别测量20个半骨盆标本髋臼前、后缘到髂前下棘、髂耻隆起和耻骨结节的距离，确定和制作髋臼前柱系列断面，并测量各断面上各进钉点的安全进钉角度，将测量数据输入到SPSS10.0软件进行统计学分析。

During en mass retraction of upper anterior teeth with straight wire technique, the length of anterior hook mainly influenced anteroposterior moving pattern of anterior teeth. As anterior hook increased from 0 to 6mm, labiolingual displacements of lateral incisor varied form lingual tipping to lingual translation and lingual controlling root movement, while 3-D displacements of other teeth only increased in account.

3直丝弓矫治技术整体内收上前牙时，牵引钩的长度主要影响前牙的矢状向位移方式：牵引钩长度增加至6mm的过程中，除侧切牙在唇舌向上由舌向倾斜运动变为舌向整体平移和舌向控根运动外，前牙的三维位移只有数量的增大，趋势基本保持不变。

The results were expressed in mean±1SD. Pearson X~2 test and One-way ANOVA test were used. The data analyzed using the SPSS (version 11.5). Results: The sensitivity, specificity, positive and negative value of US for the LPEH model on the children cadaver were 88%, 84%, 79%, 91%, respectively. With regard to the thickness of femora head cartilage, the thickness of the anterior layer or posterior layer, there were no significant differences among three groups. However, the anterior layer was thicker than the posterior layer in three groups. The fluid in hip joint was detected in all of 21 symptomatic hips, which was clear commonly (90%) in early procedure. The amount of fluid in anterior recess showed a positive correlation with age (p .05). No fluid was detected in the asymptomatic and normal hips (2mm). The mean maximum width of inferomedial recess was significantly larger than that of anterior recess (12.50±4.04mm vs.4.35±0.8mm, p 0.05) in the symptomatic hip joints. The echogenic entrapped labral plicaes were demonstrated in the inferomedial recess in all of 21 children with LPEH, whose length and width ranged from 5.3mm-25.0mm (mean,15.6±5.6mm) and from 4.0mm-17.0mm (mean,8.9±7.8mm).

结果1，尸体LPEH髋关节模型的超声诊断敏感性、特异性分别为88％、84％，阳性预测值、阴性预测值分别为79％、91％。2，21例患儿的LPEH患髋(21侧)、健髋(21侧)，以及21例正常儿童健髋(42侧)的超声检查显示：髋关节周围软组织及股骨头无形态结构差别；股骨头软骨厚度无统计学差异(3.5±0.5mm vs.3.6±0.4mm vs.3.6±0.5mm，p＞0.05)；关节囊前层及后层厚度无统计学差异(前层厚度2.79±0.74 mm vs.2.56±0.40mm vs.2.56±0.72mm；后层厚度2.70±0.82mm vs.2.48±0.54mm vs.2.44±0.58mm，p＞0.05)，但LPEH患髋关节囊前、后层均较后二组有增厚趋势。3，LPEH患髋均存在关节腔内积液，且早期较为清晰；积液以髋关节内下间隙明显，内下间隙较前间隙明显增宽(12.50±4.04mm vs.4.35±0.8mm，p＜0.05)，其内见嵌顿滑膜唇皱襞呈稍强回声的占位性团块，长约15.6±5.6mm，宽约8.9±7.8mm，90.5％(19／21)嵌顿皱襞内未见血流信号。4，所有LPEH患髋治疗后超声复诊均显示正常。

In this thesis, we find that dlg is indispensible in the establishment of anterior-posterior and dorsal-ventral polarity of drosophila oocyte. Removal of Dlg function from the posterior follicle cells using the FLP/FRT system leads to disruption of oocyte skeleton reconstruction that is elicited by the failure of those posterior cells to differentiate normally in mid-oogenesis. We demonstrate that abnormity of Notch, JAK-STAT and EGFR signal pathway in dlg mutants contributes to this aberrant differentiation. dlg null mutant also blocks the normal differentiation of two groups of anterior follicle cell-stretched cell and centripetal cell, but not border cell, with a lower penetrance. However unlike the result in posterior follicle cells, Notch and JAK-STAT signaling are both undisrupted in all mutant anterior follicle cells, implying other fate determinants may be involved.

我们的研究发现，后端滤泡细胞中的Dlg在果蝇卵子发生中期卵母细胞前后轴和背腹轴建立过程中也是必须的，PFC中dlg完全缺失型突变引起PFC的分化异常，导致卵子发生中期卵母细胞骨架重组异常，Stau、Grk等极性决定蛋白定位错误。dlg突变阻碍了Notch、JAK-STAT、EGFR等调节PFC分化的信号通路的激活。dlg突变的PFC也没有获得前端滤泡细胞命运。dlg突变不影响前端滤泡细胞群中边界细胞的分化，但是在一定程度上影响伸展细胞和向心细胞的分化，并且这种影响不依赖于前端滤泡细胞Notch或JAK-STAT信号激活的异常。

Results The anterior bundle of ulnar collateral ligament originates from the inferior aspect of the medial epicondyle and inserts immediately adjacent to the joint surface on the ulna near the sublimis tubercle. The posterior bundle originates from the medial epicondyle slightly posterior to its most inferior portion and inserts broadly on the olecranon process. The lateral collateral ligament arises from the inferior aspect of the lateral epicondyle. Two types of conjoined lateral collateral and annular ligamentous insertions on the ulna were observed. Type Ⅰ(61.2％) was bilobate and type Ⅱ(38.8％) was a single broad conjoined type with insertion on the ulna. The anterior band of anterior bundle was more tighten than the posterior band as the elbow flexed less than 60°. When the elbow flexed over 60°, the two parts of anterior bundle were equally tightened. The posterior bundle was tightened as the elbow was flexed more than 90°. The lateral collateral ligament was tightened gradually as the elbow moved in flexion.

结果(1)尺侧副韧带前束起于肱骨内上髁的前下方，止于尺骨冠突内侧的小结节；后束起于肱骨内上髁的内下方，止于尺骨鹰嘴内侧的骨面；(2)桡侧副韧带起于肱骨外上髁的外下方，其纤维部分止于环状韧带，部分止于尺骨冠突的外下方；桡侧副韧带和桡骨环状韧带在尺骨上的止点有两种类型：Ⅰ型占61.2％，桡侧副韧带的部分纤维汇于环状韧带的尺骨止点，另一部分纤维单独止于稍远的尺骨上；Ⅱ型占38.8％，桡侧副韧带和环状韧带形成一宽的纤维止于尺骨上；(3)在肘关节屈曲60°以前，尺侧副韧带前束的外侧部紧张而内侧部较松弛，肘关节屈曲超过60°后，前束内外侧处于同程度的紧张状态；尺侧副韧带的后束在肘关节屈曲超过90°后才被拉紧；(4)桡侧副韧带在肘关节不同屈曲状态时其紧张度逐渐增加，当肘关节屈曲超过90°时，桡侧副韧带被明显拉长。

Situated anterior to the frontal bone.

前额骨的位于额骨前部的

Situated anterior to the frontal bone.

又称前焦点。凸透镜前面的主焦点

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失