查询词典 anoxemia

He-Ne laser irradiation combined with salvia miltiorrhiza injection can treat ischemia and anoxemia well in clinic, but the mechanism remains obscure.

临床上低强度He-Ne激光与丹参注射液配合使用治疗缺血、缺氧性心血管疾病取得良好疗效，但其机理未明。

Sleep apnea syndrome is regarded as the most important sleep disorder discovered in the 20th century as well as the significant research direction for sleep medicine. Sleeping breath-ceasing results in a symptom of repeated arterial anoxemia in sleeping, which can easily cause harm to cardio- pulmonary and causes sequela and complicating disease such as excessive day-time sleepiness and drowsy driving, even sudden death in sleeping. In such situations, the disease not only consume a lot of medical resources but also has a bad impact on the patient' living quality.

睡眠呼吸中止症候群被认为是二十世纪所发现最重要的睡眠障碍，也是睡眠医学重要的研究方向，患者因睡眠呼吸中止造成睡眠期间反覆缺氧的结果而容易导致心肺功能受损、白天嗜睡、疲劳驾驶等并发症与后遗症，严重者甚至造成睡眠中猝死，不但耗费医疗资源，也将严重影响患者生活品质。

Background: The neuron death resulting from traumatic brain injury can be classified into 3 types:(1)neuron death due to primary injury;(2)neuron necrosis due to secondary injury such as hemorrhage, compression, anoxemia and ischemia;(3)neuron apoptosis due to inflammatory factor, cytokine,, excitatory transmitter, Ca~(2+) overload and oxygen radical et al.

引言创伤性脑损伤所致的神经元死亡主要有三种：①原发性损伤所致的神经元直接死亡；②外伤后出血、压迫、缺血缺氧等继发性损伤因素所引起的神经元坏死；③炎性介质、细胞因子、兴奋性递质、Ca~(2+)超载、氧自由基等因素所诱发的神经元凋亡。

There was an obvious increase of insulin receptor gene and protein in the cerebral ischemia reperfusion tissues in rats. The positive cells such as neuron, neuroglia cells, vascular endothelium cells possibly participated in regulating the processes of energy metabolism of cells and neovascularization. It implied that the high expressions of insulin receptors in vascular endothelium cells in ischemic zones possibly participated in regulating the pathophysiological changes of the blood vessels in ischemic zones; The higher expressions of insulin receptors in different cells were possibly one of the self-protective machanisms in which the ischemic tissues confront the anoxemia injury.

脑缺血再灌注大鼠脑组织胰岛素受体基因和蛋白水平表达增加；半暗带区神经元、部分神经胶质细胞及血管内皮细胞等阳染细胞可能参与脑缺血后组织细胞的能量代谢、促新生细胞形成等病理生理调节过程；胰岛素受体在缺血区血管内皮细胞高表达提示其可能在缺血区血管的病理生理变化中起某种调节作用；胰岛素受体在不同细胞中表达增高可能是缺血脑组织对抗缺血缺氧损伤的自身保护机制之一。

The typical pathological characteristics of SPTs may result from gradual degenerative changes induced anoxemia in some SPT's areas. The heterogeneity of SPTs on different antibody markers showed that the SPTs may be originated from pancreatic embryonic stem cells, and result from immature differentiation of the pluripotential stem cells during pancreatic genesis.

SPT典型病理特征是由于肿瘤组织不同区域相对缺血、缺氧所造成的退行性变的结果，SPT表达多种组织来源的抗原，反映其可能来源于胰腺干细胞及与其发育密切相关的胚胎神经嵴的神经前体细胞，且在发育过程中发生分化不成熟的结果。

In the survival group, patients' blood dynamics were stable gradually, DO2 and VO2 increased obviously, the blood lactic acid level was low, after complex therapy the patients were survival, however, in the death group the data demonstrated that patients' blood dynamics were unstable, the DO2 and VO2 was difficult to increase, and the blood lactic acid kept at high level, it showed that the tissues were seriously inthe condition of ischemia and anoxemia, the cell function failure was irreversible, although many kinds of complex therapy were carried on, the patient still died finally.

生存组中，患者血液动力学逐渐平稳，DO2和VO2均明显升高，血乳酸水平较低，经综合治疗后患者得于存活，而死亡组数据显示，患者血液动力学不稳定，DO2和VO2的提高非常困难，且血乳酸水平持续较高，提示组织缺血缺氧严重，细胞功能衰竭不可逆，虽采取多种措施进行综合治疗，但患者最终仍然死亡。

ObjectiveSevere traumatic patients always had a severe blood loss, for maintaining blood supply of heart and head, the gut would appear ischemic and anoxemia through the mechanisms of intestinal ischemic, reperfusion and release of mediators of inflammation and so on, which could cause functional impairment of intestinal barrier and translocation of intestinal bacterium and endotoxin, accordingly, induce the occur of SIRS (systemic inflammatory response syndrome), sepsis and MODS (multiple organ dysfunction syndrome).

目的严重创伤常伴严重失血，机体为维持心、脑的血供，肠道首先出现缺血缺氧，通过肠道缺血、再灌注、炎症介质的释放等机制，引起肠道屏障功能障碍，肠内细菌及内毒素移位，从而导致SIRS、脓毒症和MODS的发生。

(1) cerebral ischemical reperfusion injury rats'limbs motor function is variable. Acupuncture could promote lims'functional recovery.(2) PCNA masc cells is visible in cerebral ischemical semidarkness region. There is cell regeneration phenomenon. Acupuncture could strengthen injury region's PCNA expression, could profit injury recovery and functional reconstruction.(3) In ischemia semidarkness region for the model group and acupuncture group, PCNA masc cells percentage of 14days group is lower than 7days group. Along with the recovery of injury, cell multiplication is weaken.(4) In cerebral ischemia semidarkness region, there is VEGF masc cells and regeneration phenomenon. Acupuncture could strengthen injury region's VEGF expression, could profit protection after injury and blood vessel regenerate.(5) In ischemia semidarkness region for the model group and acupuncture group, VEGF masc cells percentage of 14days group is lower than 7days group. Along with the recovery of semidarkness region, ischemia and anoxemia state is getting improved, and VEGF is reduce.(6) As there are PCNA and VEGF masc cells in brain injured region, we could conclude that, after brain ischemical reperfusion injury, there are blood vessel regeneration phenomenon. Acupuncture could promote blood vessel regeneration, recovery blood supply sufficiently and quickly, and promote the recovery of brain injury region.(7)The VEGF masc cells percentage of inhibitor group is lower than acupuncture group. It state that the effect of acupuncture promote VEGF is partly depend on the existing of eNOS.

实验结论：(1)脑缺血再灌注损伤后大鼠的肢体运动功能发生改变，针刺可以促进肢体功能恢复；(2)脑缺损伤区可见PCNA阳性细胞，存在细胞再生现象，针刺可以增强损伤区PCNA的表达，有利于损伤的修复和功能重建；(3)针刺组和模型组14d时缺血损伤区PCNA阳性细胞百分比低于7d组，随着损伤逐渐得到修复，细胞增殖现象减弱；(4)脑缺血损伤区可见VEGF阳性细胞，存在内皮型细胞再生现象，针刺可以增强损伤区VEGF的表达，有利于脑损伤后保护和缺血区血管再生；(5)针刺组和模型组14d时缺血损伤区VEGF阳性细胞百分比低于7d组，随着缺血损伤的修复，缺血缺氧状态得到改善，产生的VEGF减少；(6)由于脑损伤区同时出现PCNA阳性细胞和VEGF阳性细胞，前者是增殖细胞的标志，后者是促进血管再生的重要因子，可以推断，脑缺血再灌注损伤后脑内存在血管再生现象，针刺可以促进损伤区的血管再生，更迅速而充分的恢复损伤区的血供，促进脑损伤区的修复；(7)抑制剂针刺组脑损伤区VEGF阳性细胞百分比与针刺组相比有不同程度的降低，说明针刺促进缺血损伤区VEGF表达部分依赖eNOS的存在。

Anoxemia Hypercapnia Morris water maze Choline acetyl-transferase Puerarin

低氧血症；高碳酸血； Morris水迷宫；胆碱乙酰转移酶；葛根素

Besides, HIF-1 can quickly induce a lot of expressions and the adjustment of anoxia-induced genes, so as to enhance the hypoxia-induced genetic transcription and increase the expressions, and engender physiological effects, such as adjusting the transcription of EPO genes to increase their production, thereby the red blood cells quantity is enlarged, which strengthens the ability of oxygen transportation and mitigates anoxia; adjusting VEGF genetic transcription to engender more blood capillaries, consequently the transportation and supply of oxygen and substance of energy source are strengthened; adjusting the glycolytic enzyme to enhance glycolysis ability under anoxemia condition and increase energy supply; functioning on HO-1 genes in vascular smooth muscle cells to produce HO-1, which can engender NO and CO as pneumatic signal molecules to activate the guanylate cyclases, thus CGMP level is improved to make the vascular smooth muscles chalasia, to restrain platelet agglutination, so that theblood flow and vascular permeability are increased, and the anoxic tissues obtain ample oxygen supply, etc..

在低氧环境中，HIF-1可以被很快诱导大量表达并介导低氧诱导基因的调控，使低氧诱导基因转录增强，表达产物增多，产生生理效应。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。