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WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

WD40域，在真核蛋白质的数量发现，涵盖了包括各种功能适配器/信号转导，mRNA前体细胞骨架组装加工和管理模式；通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长，因而得名WD40；介于生长激素和WD一个保守的核心，作为一个稳定的螺旋桨式平台，可以绑定的蛋白可以稳定或可逆，形成了一个螺旋桨式与每个刀片是一个四叶片结构组成若干链反平行的β-片；与数份检测实例假设，形成了聚大结构，每个WD40重复序列形成了前三个一个刀片和绞线的最后在未来的刀片链，最后C -末端WD40重复完成了第一WD40重复叶片结构，创造螺旋桨的封闭环结构，对螺旋桨顶部和底部表面残留的建议，配合和其他蛋白质的相互作用/或小配体； 7重复副本，目前这条路。

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

WD40域，在真核蛋白质的数量发现，涵盖了包括各种功能适配器/信号转导，mRNA前体细胞骨架组装加工和管理模式；通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长，因此得名WD40；之间的生长激素和WD是一个保守的核心，作为一个稳定的螺旋桨式平台，可以绑定的蛋白可以稳定或可逆性；形式与每个刀片是一个四叶片组成的几个类似结构的螺旋桨，搁浅反平行β-负债表；很少检测副本实例假设，形成了聚大结构，每个WD40重复序列形成了前三个链的一个刀片，并在未来的刀片上链，最后C -末端WD40重复完成了第一WD40重复叶片结构，创造螺旋桨的封闭环结构，对螺旋桨顶部和底部表面残留物，则建议协调与其他蛋白质和/或小配体； 7重复副本存在于相互作用这条路。

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are propos

WD40域，在真核蛋白质的数量发现，涵盖了包括各种功能适配器/信号转导，mRNA前体细胞骨架组装加工和管理模式；通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长，因而得名WD40；介于生长激素和WD一个保守的核心，作为一个稳定的螺旋桨式平台，可以绑定的蛋白可以稳定或可逆，形成了一个螺旋桨式与每个刀片是一个四叶片结构组成若干链反平行的β-片；与数份检测实例假设，形成了聚大结构，每个WD40重复序列形成了前三个一个刀片和绞线的最后在未来的刀片链，最后C -末端WD40重复完成了第一WD40重复叶片结构，创造螺旋桨的封闭环结构，对螺旋桨顶部和底部表面残留的建议，配合和其他蛋白质的相互作用/或小配体； 7重复副本，目前这条路。

I soon found a way to convince him that I would do him no harm, and taking him up by the Hand laugh'd at him, and pointed to the Kid which I had kill'd, beckoned to him to run and fetch it, which he did; and while he was wondering and looking to see how the Creature was kill'd, I loaded my Gun again, and by and by I saw a great Fowl like a Hawk sit upon a Tree within Shot; so to let Friday understand a little what I would do, I call'd him to me again, pointed at the Fowl which was indeed a Parrot, tho' I thought it had been a Hawk, I say pointing to the Parrot, and to my Gun, and to the Ground under the Parrot, to let him see I would make it fall, I made him understand that I would shoot and kill that Bird; accordingly I fir'd and bad him look, and immediately he saw the Parrot fall, he stood like one frighted again, notwithstanding all I had said to him; and I found he was the more amaz'd, because he did not see me put any Thing into the Gun; but thought that there must be some wonderful Fund of Death and Destruction in that Thing, able to kill Man, Beast, Bird, or any Thing near, or far off; and the Astonishment this created in him was such, as could not wear off for a long Time; and I believe, if I would have let him, he would have worshipp'd me and my Gun: As for the Gun it self, he would not so much as touch it for several Days after; but would speak to it, and talk to it, as if it had answer'd him, when he was by himself; which, as I afterwards learn'd of him, was to desire it not to kill him.

其实，对星期五，我根本用不着采取任何防范措施。任何其他人都不可能有像星期五这样忠诚老实、听话可爱的仆人。他没有脾气，性格开朗，不怀鬼胎，对我又顺从又热心。他对我的感情，就像孩子对父亲的感情，一往情深。我可以说，无论何时何地，他都宁愿牺牲自己的生命来保护我。后来，他的许多表现都证明了这一点，并使我对此毫不怀疑。因此，我深信，对他我根本不用防备。

Objective To study the effects of heat-killed Penicillium marneffei on the expressions of toll-like receptor-4 (TLR-4),toll-like receptor-2 (TLR-2) and dendritic cell associated C-type lectin-1 (Dectin-1)and the production of the proinflammatory cytokine tumor necrosis factor-α.

目的 研究马尔尼菲青霉对巨噬细胞模式识别受体TLR-2、TLR-4、Dectin-1的表达及促炎因子TNF-α分泌的影响。

Objective To study the effects of heat-killed Penicillium marneffei on the expressions of toll-like receptor-4 (TLR-4),toll-like receptor-2 (TLR-2) and dendritic cell associated C-type lectin-1 (Dectin-1)and the production of the proinflammatory cytokine tumor necrosis factor-α.

办法马尔尼菲青霉酵母相菌液与小鼠腹腔巨噬细胞共培养24h，采用流式细胞技术检测巨噬细胞TLR-2、TLR-4及Dectin-1的平均荧光强度；共聚焦显微镜观察荧光染色的受体；ELISA法测定培养液上清中TNF-α的浓度；Real time PCR检测不同时间段TNF-α的mRNA表达。

Arabian Nights Oh I come from a land, from a faraway place Where the caravan camels roam Where it's flat and immense And the heat is intense It's barbaric, but hey, it's home [Original first verse (1992-93):] Oh I come from a land, from a faraway place Where the caravan camels roam Where they cut off your ear If they don't like your face It's barbaric, but hey, it's home } When the wind's from the east And the sun's from the west And the sand in the glass is right Come on down Stop on by Hop a carpet and fly To another Arabian night Arabian nights Like Arabian days More often than not Are hotter than hot In a lot of good ways Arabian nights 'Neath Arabian moons A fool off his guard Could fall and fall hard Out there on the dunes

阿拉伯之夜噢我来自一片土地，从遥远的地方那里有大篷车和骆驼在漫游它广阔和宏大他有着火热的激情这是野蛮的，但是嘿，这就是我的家 [原件第一版（ 1992-93 ）： ] 噢我来自一片土地，从遥远的地方那里有大篷车和骆驼在漫游在那里他们会切下你的耳朵如果他们不喜欢你的面庞他是野蛮的，但是嘿，这是我的家当风从东方刮来太阳从西边升起杯中的沙子也许是对的起起落落浮浮沉沉围着地毯起舞飞翔另一个阿拉伯之夜阿拉伯之夜像阿拉伯的生活往往就是这样的比火热还要热在许许多多的时候阿拉伯之夜靠着阿拉伯的月亮一个傻瓜迷失了他的方向可能下落下落直到消失在那片沙丘之后实在是不好翻译自己再润色一下吧

The numbers of clusters made up of 1551 and 1541 bonded pairs representing the non-crystal structure occupy predominate position and the small numbers of clusters made up of 1431, 1661 and 1441 bonded pairs coexist in the non-crystal system at 4×10〓K/s cooling rate, thus there exist a large number of icosahedra clusters in the non-crystal system. The numbers of clusters made up of 1421 bonded pairs corresponding to the fcc-like structure occupy predominate position and the small numbers of clusters made up of 1422 and 1551 bonded pairs coexist in the crystal system during the 4×10〓K/s cooling process, thus the system can form the regular fcc-like structure.

在4×10〓K/s的冷速下，标征体系非晶结构的五重对称键型1551和1541所形成的小团簇数量在非晶体系中占主导位置，同时还存在少量的1431、1441和1661等其它键型形成的小团簇，这样，体系中含有大量的二十面体团簇结构；在4×10〓K/s的冷速下，标征面心立方结构的1421键型所形成的小团簇数量在晶体中占第一位，同时还存在一定量的1422、1441和1661等其它类型的键对所形成的团簇，体系最终形成面心立方结构。

Say: If the whole of mankind and Jinns were to gather together to produce the like of this Qur'an, they could not produce the like thereof, even if they backed up each other with help and support.

你说：&如果人类和精灵联合起来创造一部像这样的《古兰经》，那末，他们即使互相帮助，也必不能创造像这样的妙文。&

Niba Valley covered by the endless stretch of Chinese larches and, Multicolor Ponds of Yutong Valley hidden under the Pagela Holy Mountain, and the simple and primitive Yixiantian of Kari Valley are with beautiful scene, florid colors, like a song, like a picture.

泥巴沟万亩红杉林、深藏于帕格拉神山下的鱼通沟五彩池、古朴原始的卡日沟一线天等，风光秀美、色彩绚丽、如歌如画。1935年6月中旬，长征的中央红军来到硗碛，留下了毛主席故居、朱总司令故居、凉水井、红军誓师坪、红军伞等红色遗迹，让人束然起敬、浮想联翩。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。