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Father, thy word is past, man shall find grace; And shall grace not find means, that finds her way, The speediest of thy winged messengers, To visit all thy creatures, and to all [ 230 ] Comes unprevented, unimplor'd, unsought, Happie for man, so coming; he her aide Can never seek, once dead in sins and lost; Attonement for himself or offering meet, Indebted and undon, hath none to bring: [ 235 ] Behold mee then, mee for him, life for life I offer, on mee let thine anger fall; Account mee man; I for his sake will leave Thy bosom, and this glorie next to thee Freely put off, and for him lastly dye [ 240 ] Well pleas'd, on me let Death wreck all his rage; Under his gloomie power I shall not long Lie vanquisht; thou hast givn me to possess Life in my self for ever, by thee I live, Though now to Death I yield, and am his due [ 245 ] All that of me can die, yet that debt paid, Thou wilt not leave me in the loathsom grave His prey, nor suffer my unspotted Soule For ever with corruption there to dwell; But I shall rise Victorious, and subdue [ 250 ] My Vanquisher, spoild of his vanted spoile; Death his deaths wound shall then receive, and stoop Inglorious, of his mortal sting disarm'd.

父亲啊，您的话一言为定，人将蒙受恩惠；何不想方设法派遣您飞得最快的长翼的使者去遍访你的一切生灵，叫他们都前来领受幸福，不受阻挠，不等哀求，也不用请愿！这样前来的人们，真值得庆幸！否则，一判死罪，而且沉沦，便永远不得救助；负债而破产，连赎买自己的东西都没有了。那好吧，请看我，我要以自己的生命，救赎他们，请把怒气发在我身上；把我当做凡人看，我要为凡人而离开父亲的怀抱，情愿抛弃仅次于我父的光荣地位，甘愿为他终于一死；任凭'死'把他全部的愤怒都发泄在我身上。在他的黑暗统治下，我不会永远屈服；您既给了我生命，永远为我所有，我因您而活，虽然如今我让步于'死'，凡我应当死的一切，都归他所有，但别让我所还的债，作为他的食饵，却把我遗留在令人憎恶的坟墓里，别让我纯洁无瑕的灵魂，永远住在坟茔里，与腐朽同居。我将要胜利而再起，制伏我的征服者，夺取他所夸耀的战利品。那时，'死'将受到致命的创伤，他那致命的毒刺将被拔掉，他的武装将被解除，他会大大丢脸。

It seems that i can't force feeling as everything's dancing around a circle that i cannot see and all the times slipping away we try to remember the days gathering all of the pictures we took together and apart we will die as everything's dancing around just trying to stay on the ground i find myself reaching tog rab, you away feelings today, don't look away from me and holding our hands out we'll grow, everyday losing the way, no more alone we will stay as everything's dancing around a circle that i cannot see and all the times slipping away we try to remember the days gathering all of the pictures we took together and apart we will die as everythings dancing around just trying to stay on the ground.

我似乎无法强迫感吗像所有的舞蹈一个圆，使我不能看见和所有的时间正在流逝我们试图记住的日子一去不复返了收集所有的图片我们将一起，除了死像所有的舞蹈只想呆在地面上我发现自己要达到，你走吧。

It was a thirty eight, the poor mans machete Held it in my hand, thinking damn man it's heavier then expected, Wedged it behind my belt buckle Knowin that its evil, even thought that I could smell trouble The extra strength felt weak, But over there on the corner saw what I needed and proceeded to cross the Street Put the heat in the mail box to loose it Figured that the post office knows whats best to do with it Mosey down the road thinkin' bout the old I use to roam this zone with two feet of snow Right here, this use to be a record shop I've gotten love, I've gotten drunk, I've gotten beat up in that parking lot I've had my lake street pride for three decades These alleyways, and these streetlights have seen my best days Before I was a germ learnin how to misbehave, All the way to the grave, south side is my resting place Took a right on Lindale I'm getting near But then the road became empty and the people disappear'd The clowds ran away, opened up the sky And one by one I watched every constellation die And there I was frozen, standin in my backyard Face to face, eye to eye, starin at the last star I should've known, walked all the way home To find that she wasn't here, I'm still all alone

It是三十八，贫困者大砍刀 Held它在我的手，想法的人它是更重然后期望， Wedged它在我的皮带扣之后它邪恶，甚而认为的Knowin我可能嗅到麻烦感到的The额外力量微弱， But在角落在那看了什么我需要并且继续横渡 Street Put在疏松它的邮箱的热邮局知道的Figured什么是最佳做与它 Mosey击倒路thinkin回合老 I用途漫游有雪的二英尺的这个区域 Right这里，这个用途是记录商店 I在那停车场得到爱，我得到了喝，我得到了打了 I有我的湖街道自豪感三十年 These巷道和这些街灯看了我的最佳的几天 Before我是毒菌learnin如何行为不端，一直对严重，南侧是我的休息处 Took在我得到近的Lindale的权利另一方面But路成为了空和人disappear'd The clowds跑掉了，开放天空 And我逐个观看每个星座死那里And我在我的后院结冰了，替换者面对面，眼睛注视的，在最后星的starin I应该知道，一直走在家 To发现她没有在这里，我仍然是所有单独的

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

THAT it be recommended to the several States to appoint the First Thursday in May next to be a Day of Fasting, Humiliation, and Prayer to Almighty God, that he will be pleased to avert those impending Calamities which we have but too well deserved: That he will grant us his Grace to repent of our Sins, and amend our Lives according to his Holy Word: That he will continue that wonderful Protection which hath led us through the Paths of Danger and Distress: That he will be a Husband to the Widow, and a Father to the fatherless Children, who weep over the Barbarities of a Savage Enemy: That he will grant us Patience in Suffering, and Fortitude in Adversity: That he will inspire us with Humility, Moderation, and Gratitude in prosperous Circumstances: That he will give Wisdom to our Councils, Firmness to our Resolutions, and Victory to our Arms: That he will bless the Labours of the Husbandman, and pour forth Abundance, so that we may enjoy the Fruits of the Earth in due Season: That he will cause Union, Harmony, and mutual Confidence to prevail throughout these States: That he will bestow on our great Ally all those Blessings which may enable him to be gloriously instrumental in protecting the Rights of Mankind, and promoting the Happiness of his Subjects: That he will bountifully continue his paternal Care to the Commander in Chief, and the Officers and Soldiers of the United States: That he will grant the Blessings of Peace to all contending Nations, Freedom to those who are in Bondage, and Comfort to th e Afflicted: That he will diffuse Useful Knowledge, extend the Influence of True Religion, and give us that Peace of Mind which the World cannot give: That he will be o ur Shield in the Day of Battle, our Comforter in the Hour of Death, and our kind Pare nt and merciful Judge through Time and through Eternity.

这几个国家的推荐任命第一周四月份明年将禁食一天，羞辱、向全能的上帝祈祷，他乐意为避免即将发生的灾难，我们不过是过于当之无愧：他说，他将给予我们的恩典悔改罪过，据他自己的生命和修改罗马字：他表示将继续带领我们走过孩童美妙保障道路危险之中：他将丈夫的寡妇，对子女的父亲，谁哭了一个野蛮残暴的敌人：他会耐心地给予我们的痛苦，在逆境和毅力：他将激励我们与谦卑温和、感激骏情形：我们的智慧，他会给议会决议的坚定性和胜利的武器：他会保佑辛勤的husbandman，浇出丰让我们可以享受到应有的地球季节：他会引起联盟和谐并在这些国家的相互信任为准：他将赐给我们的伟大祝福所有的盟友可能使他被光荣地有助于人类的权利保障，他的幸福和促进学科：他的父亲说，他将继续照料bountifully统帅，而美国官兵：他会给予祝福所有抗衡国和平、自由那些束缚，安慰次电子折磨：他将弥漫有用的知识，扩大影响，真正的宗教，并给予我们安心而不能给世界：他将澳乌尔盾牌当天的战斗中，在我们的抚慰小时死亡，而我们的剥掉新台币和仁慈法官经过多次透过永恒。

THAT it be recommended to the several States to appoint the First Thursday in May next to be a Day of Fasting, Humiliation, and Prayer to Almighty God, that he will be pleased to avert those impending Calamities which we have but too well deserved: That he will grant us his Grace to repent of our Sins, and amend our Lives according to his Holy Word: That he will continue that wonderful Protection which hath led us through the Paths of Danger and Distress: That he will be a Husband to the Widow, and a Father to the fatherless Children, who weep over the Barbarities of a Savage Enemy: That he will grant us Patience in Suffering, and Fortitude in Adversity: That he will inspire us with Humility, Moderation, and Gratitude in prosperous Circumstances: That he will give Wisdom to our Councils, Firmness to our Resolutions, and Victory to our Arms: That he will bless the Labours of the Husbandman, and pour forth Abundance, so that we may enjoy the Fruits of the Earth in due Season: That he will cause Union, Harmony, and mutual Confidence to prevail throughout these States: That he will bestow on our great Ally all those Blessings which may enable him to be gloriously instrumental in protecting the Rights of Mankind, and promoting the Happiness of his Subjects: That he will bountifully continue his paternal Care to the Commander in Chief, and the Officers and Soldiers of the United States: That he will grant the Blessings of Peace to all contending Nations, Freedom to those who are in Bondage, and Comfort to th e Afflicted: That he will diffuse Useful Knowledge, extend the Influence of True Religion, and give us that Peace of Mind which the World cannot give: That he will be o ur Shield in the Day of Battle, our Comforter in the Hour of Death, and our kind Pare nt and merciful Judge through Time and through Eternity.

这几个国家的推荐任命一九九九年五月第一明年将禁食一天，羞辱、向全能的上帝祈祷，他乐意为避免即将发生的灾难，我们不过是过于当之无愧：他说，他将给予我们的恩典悔改罪过，据他自己的生命和修改罗马字：他表示将继续带领我们走过孩童美妙保障道路危险之中：他将丈夫的寡妇，对子女的父亲，谁哭了一个野蛮残暴的敌人：他会耐心地给予我们的痛苦，在逆境和毅力：他将激励我们与谦卑温和、感激骏情形：我们的智慧，他会给议会决议的坚定性和胜利的武器：他会保佑辛勤的husbandman，浇出丰让我们可以享受到应有的地球季节：他会引起联盟和谐并在这些国家的相互信任为准：他将赐给我们的伟大祝福所有的盟友可能使他被光荣地有助于人类的权利保障，他的幸福和促进学科：他的父亲说，他将继续照料bountifully统帅，而美国官兵：他会给予祝福所有抗衡国和平、自由那些束缚，安慰次电子折磨：他将弥漫有用的知识，扩大影响，真正的宗教，并给予我们安心而不能给世界：他将澳乌尔盾牌当天的战斗中，在我们的抚慰小时死亡，而我们的剥掉新台币和仁慈法官经过多次透过永恒。

And if they be ashamed of all that they have done, make known unto them the form of the house, and the fashion thereof, and the egresses thereof, and the entrances thereof, and all the forms thereof, and all the ordinances thereof, and all the forms thereof, and all the laws thereof; and write it in their sight; that they may keep the whole form thereof, and all the ordinances thereof, and do them.

叫他们对自己的所行的丑事而感到惭愧。你要划出殿的图形、结构、出路、进口和所有的式样，并将各种规定和和种法律告知他们，在他们眼前写出好叫他们遵守各种法律和规定，一一奉行。如果他们觉得自己可耻，你就向他们说明这圣殿的设计：包括圣殿的图样、出入口、外形、内部的布置，和所有的条例规则。你要把这一切写下来，让他们知道该怎样布置，并且按照条例规则执行。

We are mature enough now to stand the shock of learning that much of what we were taught in our youth was wrong, or improperly understood by those who were teaching it, or perhaps shaded a bit, the shading resulting from the personal needs of the teachers, who as human beings had a tendency to introduce some of their heart's blood into their work, and sometimes this may not have been of the first water, this heart's blood, and even if they thought they were moving the "knowledge" out, as the Board of Education had mandated, they could have noticed that their sentences weren't having the knockdown power of the new weapons whose bullets tumble end-over-end (but it is true that we didn't have these weapons at that time) and they might have taken into account the fundamental dubiousness of their project (but all the intelligently conceived projects have been eaten up already, like the moon and the stars) leaving us, in our best clothes, with only things to do like conducting vigorous wars of attrition against our wives, who have now thoroughly come awake, and slipped into their striped bells, and pulled sweaters over their torsi, and adamantly refused to wear any bras under the sweaters, carefully explaining the political significance of this refusal to anyone who will listen, or look, but not touch, because that has nothing to do with it, so they say; leaving us, as it were, with only things to do like floating sheets of Reynolds Wrap around the room, trying to find out how many we can keep in the air at the same time, which at least gives us a sense of participation, as though we were Buddha, looking down at the mystery of your smile, which needs to be investigated, and I think I'll do that right now, while there's still enough light, if you'll sit down over there, in the best chair, and take off all your clothes, and put your feet in that electric toe caddy and slip into this permanent press hospital gown, to cover your nakedness-why, if you do all that, we'll be ready to begin!

现在我们已经足够成熟来承受学习的震撼，以此我们来嘲笑我们年轻时候的错误，或者错误地理解教我们的人，或者也许掩饰掉它，掩饰将使得我们更需要老师，他们就像人类的趋向来将他们的一些心血用在工作上，有些时候这些已经不是第一点水了，这是心血，甚至他们是在想他们把&知识&搬了出去，广泛教育形成，他们也许已经认识到他们的句子已经没有新武器的那样的震撼力了，新武器的子弹击倒了一个又一个（但是的确哪个时候我们没有那样的武器），他们也许会被考虑进基础性不确定的留给我们的项目（但是所有构思高明的项目早就被吃光了，就像星星之于月亮），在我们最好的衣服中，只有一件事情可以做，就像操纵有力的战争摩擦来反对我们的妻子一样，她正在完全醒来，滑进有斑纹的闹钟中，扯下羊毛衫，放在为完成的作品上，坚决拒绝在羊毛衫里穿任何凶罩，小心翼翼地想任何听众解释这个拒绝政治上的重大意义，或者观众，但不包括触抹者，因为这没有任何意义，所以他们说，不要管我，只有一件事情要做，就像雷诺茨？

We are mature enough now to stand the shock of learning that much of what we were taught in our youth was wrong, or improperly understood by those who were teaching it, or perhaps shaded a bit, the shading resulting from the personal needs of the teachers, who as human beings had a tendency to introduce some of their heart's blood into their work, and sometimes this may not h39e been of the first water, this heart's blood, and even if they thought they were moving the "knowledge" out, as the Board of Education had mandated, they could h39e noticed that their sentences weren't h39ing the knockdown power of the new weapons whose bullets tumble end-over-end (but it is true that we didn't h39e these weapons at that time) and they might h39e taken into account the fundamental dubiousness of their project (but all the intelligently conceived projects h39e been eaten up already, like the moon and the stars) le39ing us, in our best clothes, with only things to do like conducting vigorous wars of attrition against our wives, who h39e now thoroughly come awake, and slipped into their striped bells, and pulled sweaters over their torsi, and adamantly refused to wear any bras under the sweaters, carefully explaining the political significance of this refusal to anyone who will listen, or look, but not touch, because that has nothing to do with it, so they say; le39ing us, as it were, with only things to do like floating sheets of Reynolds Wrap around the room, trying to find out how many we can keep in the air at the same time, which at least gives us a sense of participation, as though we were Buddha, looking down at the mystery of your 56ile, which needs to be investigated, and I think I'll do that right now, while there's still enough light, if you'll sit down over there, in the best chair, and take off all your clothes, and put your feet in that electric toe caddy and slip into this permanent press hospital gown, to cover your nakedness-why, if you do all that, we'll be ready to begin!

现在我们已经足够成熟来承受学习的震撼，以此我们来嘲笑我们年轻时候的错误，或者错误地理解教我们的人，或者也许掩饰掉它，掩饰将使得我们更需要老师，他们就像人类的趋向来将他们的一些心血用在工作上，有些时候这些已经不是第一点水了，这是心血，甚至他们是在想他们把&知识&搬了出去，广泛教育形成，他们也许已经认识到他们的句子已经没有新武器的那样的震撼力了，新武器的子弹击倒了一个又一个（但是的确哪个时候我们没有那样的武器），他们也许会被考虑进基础性不确定的留给我们的项目（但是所有构思高明的项目早就被吃光了，就像星星之于月亮），在我们最好的衣服中，只有一件事情可以做，就像操纵有力的战争摩擦来反对我们的妻子一样，她正在完全醒来，滑进有斑纹的闹钟中，扯下羊毛衫，放在为完成的作品上，坚决拒绝在羊毛衫里穿任何凶罩，小心翼翼地想任何听众解释这个拒绝政治上的重大意义，或者观众，但不包括触抹者，因为这没有任何意义，所以他们说，不要管我，只有一件事情要做，就像雷诺茨？

It is labour then which puts the greatest part of value upon land, without which it would scarcely be worth any thing: it is to that we owe the greatest part of all its useful products; for all that the straw, bran, bread, of that acre of wheat, is more worth than the product of an acre of as good land, which lies waste, is all the effect of labour: for it is not barely the plough-man's pains, the reaper's and thresher's toil, and the baker's sweat, is to be counted into the bread we eat; the labour of those who broke the oxen, who digged and wrought the iron and stones, who felled and framed the timber employed about the plough, mill, oven, or any other utensils, which are a vast number, requisite to this corn, from its being feed to be sown to its being made bread, must all be charged on the account of labour, and received as an effect of that: nature and the earth furnished only the almost worthless materials, as in themselves.

如果我们追踪一下我们食用的每块面包的劳动所提供的东西，那么将会发现这是一个不太可理解的物品清单；铁，树，皮革，树皮，木头，石头，砖，煤炭，石灰，布料，染料，沥青，焦油，桅杆，绳索，以及所有造船的材料——船运来了其他工人制造的这件工作所需要的物品——完全列举几乎不可能，至少是太长。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。