查询词典 analogues

Objective Some pentacyclic steroidal analogues with 3-hydroxy-5-ene moiety have been synthesized to evaluate inhibition of VEGF in breast cancer cells.

目的 设计合成一系列具有3-羟基－5-烯骨架的五环甾体骨架衍生物，并测试其抑制乳腺癌细胞新血管生成的活性的抑制作用。

In order to further understand the dependence of bioactivities on the structure of new fluorine-containing pesticidal compounds to build up significant ligand-receptor models, and to find out the pharmacophores of these analogues, 3D-QSAR analyses have been carried out with DISCO, CoMFA and Leapfrog approaches on the basis of our previous classical QSAR study. Firstly, the compounds were classified according to their structures.

为了能更深入地认识含氟新化合物作为农药的生物活性和其结构间的关系，建立有意义的药物-受体作用模型，寻找同类化合物的药效团，对合成的含氟化合物在经典QSAR方法研究的基础上，又进一步运用DISCO，CoMFA和Leapfrog方法研究了它们的三维构效关系。

To discover new strobilurin analogues with high pesticidal activity, a series of new strobilurin derivatives containing substituted pyrazole and pyrimide ring, which included 124 novel compounds (73 compounds containing substituted pyrazole ring and 51 compounds containing substituted pyrimide ring) were designed and synthesized. In addition, 36 new intermediates were synthesized. Their structures were characterized by ~1H NMR and elemental analysis, partial compounds were characterized by MS and IR once again.

为了发现具有更好生物活性的新型Strobilurin类化合物，本论文在详尽总结文献的基础上，设计并合成了含吡唑和嘧啶环的新型Strobilurin类化合物124个，其中含吡唑环的新型Strobilurin类化合物73个，含嘧啶环的新型Strobilurin类化合物51个；未见文献报道的中间体36个，所合成的化合物经过~1H NMR、IR、LC-MS或元素分析等确定了结构。

To discover new strobilurin analogues with high pesticidal activity, a series of new strobilurin derivatives containing substituted pyrazole and pyrimide ring, which included 124 novel compounds (73 compounds containing substituted pyrazole ring and 51 compounds containing substituted pyrimide ring) were designed and synthesized. In addition, 36 new intermediates were synthesized. Their structures were characterized by 1H NMR and elemental analysis, partial compounds were characterized by MS and IR once again.

为了发现具有更好生物活性的新型Strobilurin类化合物，本论文在详尽总结文献的基础上，设计并合成了含吡唑和嘧啶环的新型Strobilurin类化合物124个，其中含吡唑环的新加热管型Strobilurin类化合物73个，含嘧啶环的新型Strob 加热管 ilurin类化合物51个；未见文献报道的中间体36个，所合成的化合物经过1H NMR、IR、LC-MS或元素分析等确定了结构。

Researches on the transition metal complexes with polypyridyl bridging ligands, such asbipyridine, phenanthroline and their derivatives or analogues, have received considerableinterest in recent years.

近年来，联吡啶和邻菲啰啉及其衍生物等多吡啶化合物的过渡金属配合物引起了人们的极大兴趣。

Pyridoxine, pyridoxal , pyridoxamine as well as their phosphated forms are structural analogues in which pyridoxal-5"-phosphate and pyridoxamine-5"- phosphate are the biological active forms in vivo which act as the cofactors of aminotransferases, amino acid decarboxylases, cysteine desufbrase and cystathionine , etc by constant transconversions. Recently, it was discovered that B6 played a novel role in tumor growth suppression.

它包括三种结构十分近似的化合物：吡哆醇(Pyidoxine，PN)、吡哆醛(Pyridoxal，PL)和吡哆胺(Pyridoxamine，PM)，分别以磷酸化的形式发挥作用，其中吡哆醛-5'-磷酸(Pyridoxal-5'-phosphate，PLP)为B_6在体内的活性形式，通过与磷酸吡哆胺(Pyidoxamine-5-phosphate，PMP)的互变，作为多种酶(氨基转移酶、氨基酸脱羧酶、半胱氨酸脱硫酶、胱硫醚酶等)的辅酶而发挥传递基团的作用。

The biotransformation of butyl phthalide and its analogues was studied.

本文研究了芹菜甲素及其几个类似物的代谢转化。

First, the in vitro metabolism of 6-chloro butyl phthalide was investigated and a HPLC method for the study of the in vitro metabolism of butyl phthalide analogues was developed.

首先研究了6-氯正丁苯酞的体外代谢，建立了研究氯丁苯酞及其类似物体外代谢转化的HPLC分析方法，并弄清了它们代谢转化的一般规律。

The effect of silicon atom in substrate on the reaction rate and the stereoselectivity of enzymatic reactions was revealed by comparison of horse liver alcohol dehydrogenase-catalyzed stereoselective dehydrogenation of the three isomers of acetyltrimethyl propanone and their carbon analogues in aqueous/organic biphasic systems.

本项目通过对比在水－有机溶剂两相系统中，马肝醇脱氢酶催化三甲基硅烷丙酮的三个异构体及其碳类似物的光学选择性脱氢反应，揭示了底物中的硅原子对酶反应速度、立体选择性的影响规律，成功地合成了高对映体纯度的手性有机硅醇，并实现了辅酶的再生。

Specifically, the invention relates to vasoactive intestinal receptor binding peptides, derivatives and analogues of vasoactive intestinal peptide, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes.

具体地，本发明涉及到具血管活性肠受体结合特性的肽，血管活性肠肽的衍生物和类似物，和用放射性同位素标记这类肽的实施方案，以及生产、放射性标记与使用这类肽的方法和药盒进行放射性诊断和放射性治疗。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了