查询词典 analogs

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Tetrahydroisowuinolin derivatives and phthalide derivatives were designed and synthesized on the basis of a PDE4 inhibitor pharmacophore model set up through computer simulation. Some tetrahydroisowuinolin derivatives synthesized were evaluated on their activity against PDE4 for study on the structure-activity relationship.(7-cyclopentyloxy)-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155) and Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (170) showed good activity against PDE4, which were chosen as the lead compounds to design and synthesize another analogs in order to develop selective PDE4 inhibitors with better activity.

分别设计合成了以四氢异喹啉和氨基苯酞为骨架的两类小分子杂环化合物，并对部分四氢异喹啉衍生物测试了其相关的生物活性，初步确定了其构效关系，发现了两个对PDE4有较好抑制活性的先导化合物(7-cyclopentyloxy)-6-methoxy-3，4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155)和Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1，2，3，4-tetrahydroisoquinoline-3-carboxylate (170)。

ABSTRACT AIM: In order to find new type of antitumor compounds and study the contribution of hydroxyl groups on the sugar part to the antitumor activity of 8-Cl-adenosine, the retinoid analogs of adenosine and the derivatives of 8-Cl-adenosine were synthesized.

目的： 为寻找新型抗肿瘤化合物和探讨糖环羟基对8-Cl-腺苷的抗肿瘤活性的影响，合成了腺苷的维甲类似物和8-Cl-腺苷衍生物。

Professor Marcelin: I think this is a good idea because we know the nucleoside and nucleotide analogs are sublimitation and also you got your own limitations.

Marcelin教授：我认为这是个好办法，因为我们知道核苷类药物是次限制的，而每个人会有自己的限制。

Although some nuclear weapons effects such as blast and cratering have analogs in the effects of conventional weapons, many NWE are unique to nuclear use.

虽然部分核武器效应如冲击波和地面落坑与常规武器类似，但仍有许多核爆所独有的武器效应。

The speech semaphore analogs wave form and delivers a speech through IP method and ignore to is a real time appliance a traffic still a non- real time applied traffic, the pass looks shore wants to steer a simulation data convert to the speech semaphore first, is also vs simulation the speech semaphore steer 8 or 6 quantizes, then send go into to buffer store ward amid, the dimension of dampener can be sur the request select of the delay and the encode.

语音信号是模拟波形，通过IP方式来传输语音，不管是实时应用业务还是非实时应用业务，道貌岸首先要对语音信号进行模拟数据转换，也就是对模拟语音信号进行8位或6位的量化，然后送入到缓冲存储区中，缓冲器的大小可以根据延迟和编码的要求选择。

A series of analogs of fatty acid amide and fatty nitrile have been identified in shell bar section, Qaidam Basin, Tibetan Plateau by using the gas chromatography-mass spectrometry.

中文摘要：利用气相色谱质谱联用仪对青藏高原柴达木盆地察尔汗湖区贝壳堤剖面古湖相沉积物样品进行了系统地分析，检测出系列脂肪酸酰胺与脂肪腈类含氮类脂物分子化石。

A series of analogs of fatty acid amide and fatty nitrile were identified along the shell bar section of the Qaidam Basin in Qinghai-Tibet Plateau by using the gas chromatography-mass spectrometry.

中文摘要：利用气相色谱质谱联用仪对青藏高原柴达木盆地察尔汗湖区贝壳堤剖面古湖相沉积物样品进行了系统地分析，检测出系列脂肪酸酰胺与脂肪腈类含氮类脂物分子化石。

This dissertation focused on the development of new chiral capillary electrophoresis approaches for the analysis of amino acids and their analogs, resulting in some important progress as is shown below

本论文针对当前手性毛细管电泳中的一些重要问题进行研究，发展了一些新的高效手性选择体系和方法，适用于氨基酸及其类似物等的拆分，具体如下

So here I was looking for the analogs.

所以我在这里寻找类似的东西

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了