查询词典 amino acid

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

S: During incubating of embryonated egg s, the content of protein, amino acid, free amino acid increased gradually, and maintained at a higher lever within the 10 -19 days.

鸡胚蛋在孵化期间，其蛋白质、总氨基酸、游离氨基酸从孵化开始逐渐增加，1 0d～ 1 9d稳定在一个较高的水平，比未孵化的鲜鸡蛋提高 1 %以上，胎水氨基酸从第 7d开始形成，以后含量稳定在 2 。

Given an amino acid sequence, what features should be derived from it and how to formulize these features so as to represent the relationship between the sequence and the structure or function of the corresponding protein correctlyβ This is the problem of characteristic description of the amino acid sequence.

1引言 阐释蛋白质的序列一结构一功能之间的关系是后基因组时代的一项重要任务，蛋白质数据库规模的迅速增长和计算技术的发展为这项任务的研究提供了方便。

Function: D-Tryptophan is heterocyclic ring amino acid, one of the essential amino acid to human body and widely used in medicine and food industry.

用途： 色氨酸是杂环氨基酸，是一种重要的人体必须氨基酸，广泛应用于医药和食品领域，其主要用途

According to the concept that the subcellular location of an apoptosis protein is mainly determined by its amino acid sequence, the six kind of subcellular locations of apoptosis proteins were predicted by using the algorithm of the increment of diversity combined with support vector machines based on the n-peptide components of local amino acid sequence and hydropathy and hydrophobicity.

根据凋亡蛋白的亚细胞位置主要决定于它的氨基酸序列这一观点，基于局部氨基酸序列的n肽组分和序列的亲疏水性分布信息，采用离散增量结合支持向量机算法，对六类细胞凋亡蛋白的亚细胞位置进行预测。

Subcellular location of apoptosis proteins is closely related to their function. According to the concept that the subcellular location of an apoptosis protein is mainly determined by its amino acid sequence, the six kind of subcellular locations of apoptosis proteins are predicted by using of the algorithm of the increment of diversity combined with support vector machines based on the n-peptide components of global, local amino acid sequence and hydropathy and hydrophobicity.

基于一个凋亡蛋白的亚细胞位置主要决定于它的氨基酸序列这一观点，选取局部氨基酸序列的肽组分和序列的亲疏水性分布信息，采用离散增量结合支持向量机算法，对六类细胞凋亡蛋白的亚细胞位置进行预测。

According to the concept that the subcellular location of an apoptosis protein is mainly determined by its amino acid sequence, the six kind of subcellular locations of apoptosis proteins were predicted by using the algorithm of the increment of diversity combined with support vector machines based on the n-peptide components of local amino acid sequence and hydropathy and hydrophobicity.

根据凋亡蛋白的亚细胞位置主要决定于它的氨基酸序列这一观点，基于局部氨基酸序列的n肽组分和序列的亲疏水性分布信息，采用离散增量结合支持向量机算法，对六类细胞凋亡蛋白的亚细胞位置进行预测，结果表明，在Re-substitution检验和Jackknife检验下，ID—SVM算法的总体预测成功率分别达到了94.6％和84.2％；在5-fold检验和10-fold检验下，其总体预测成功率也都达到了83％以上。

OrLPT1 ORF encods a polypeptide with 535 amino acid residues (molecular mass of 57.6KDaltons), which shares more than 64% amino acid identity with some other high-affinity Pi transporters of plants. Hydropathy analysis of the deduced polypeptides showed that the OrLPT1 is highly hydrophobic and contains 12 putative membrane-spanning regions.

OrLPT1 ORF 编码长为535 个氨基酸(分子量57.6 KDaltons)的蛋白，与其他植物物种磷酸盐转运蛋白的同源性在64%以上；多肽链的疏水性分析表明，OrLPT1 具有12 个疏水的跨膜区及高亲和力磷酸盐转运蛋白中保守的3 个磷酸化作用位点：蛋白激酶C作用位点、N端糖基化部位和酪蛋白激酶II 作用部位； 3。

The polar hydrophilous amino acid Thr is replaced by an unpolar hydrophobous amino acid Ile, a hydrogen bond changed in the higher structure and the point is far away from the active center, so it doesn't influence the activity and thermostability a lot.

亲水的Thr108突变成非极性的Met，导致与该位点空间相邻的N116亲水氨基酸His的极性残基——咪唑环产生空间电位排斥，从而造成His所在的β折叠构象发生改变。

It looks like that the molecular weight of these immunopeptides were very small, and it also showed that the hydrophobe amino acid on the bottom and alkaline amino acid were important structurals of the immunopeptides.

论文主要研究结论如下：目前已报道的140余种免疫活性肽其相对分子质量都较小，通常在肽链中含有碱性氨基酸或在末端具有疏水性氨基酸。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。