查询词典 alloxan

Saururus Chinensis Baill ; alloxan ; diabetes ; polysaccharide ; experimental research

福建中医学院中心实验室；福州大学化学系；福建福州；三白草；四氧嘧啶；糖尿病；多糖；实验研究

Results: CPCC treatment was found to effectively attenuate the degenerative changes observed in alloxan-induced animals, such as hypertrophy of liver, adhesion phenomenon between adjacent hepatic lobules, crimpling and partial necrosis of hepatocytes, inflammatory cell infiltration, vacuolation, endothelial cell injury and the nuclear damage etc.

结果：CPCC处理使四氧嘧啶处理后小鼠肝脏肿大、肝小叶粘连现象明显改善；肝指数降低；减轻肝细胞变形、肝窦淤血、炎症细胞浸润及肝细胞空泡样变、血管内皮细胞损伤，核变性程度同时CPCC能有效防止四氧嘧啶所致小鼠肝脏可溶性蛋白的变化。

The results showed as:(1)Gegen decreases fasting insulin and insulin resistance index and increases insulin sensitive index of rats of insulin resistance induced by dexamethasone significantly;(2)Gegen can improve glucose tolerance of rats of insulin resistance but not to alloxan indued diabetes mice;(3)Gegen increases glucose intake of 3T3-L1 adipocytes and improves the insulin resistance of 3T3-L1 adipocytes induced by dexamethasone significantly;(4)Gegen can activate peroxisome proliferator- activated receptor gamma, make it bind to PPAR response elements;(5)Gegen can up-regulate mRNA expression of PPAR v ,aP2 and adiponectin.

结果表明：①葛根显著降低地塞米松诱导的胰岛素抵抗大鼠血清胰岛素水平和胰岛素抵抗指数，升高胰岛素敏感指数，改善大鼠的胰岛素抵抗；②葛根显著改善胰岛素抵抗大鼠的糖耐量，但对四氧嘧啶糖尿病小鼠的糖耐量没有明显的作用；③葛根显著增加胰岛素抵抗3T3-L1脂肪细胞对葡萄糖的摄取，改善地塞米松诱导的3T3-L1脂肪细胞的胰岛素抵抗；④葛根能促进HepG2肝癌细胞过氧化物酶体增殖物激活受体γ与靶基因的特异DNA序列结合，对PPARγ及其下游基因的转录具有激活作用；⑤葛根能够促进PPARγ及其下游基因脂肪酸结合蛋白(aP2)、脂联素mRNA的表达。

The blood glucose levels in many strain animal models were determined after oral administration, with the models of diabetes induced by alloxan, of hyperglycemic mice induced by epinephrine and glucose, and normal mice.

采用四氧嘧啶所致糖尿病模型、肾上腺素和葡萄糖引起的高血糖小鼠模型，以及正常小鼠口服给药，测定各模型小鼠的血糖水平；并对GXTF进行了急性毒性试验。

Methods:Established DM rats by intraperitoneal injection of Alloxan and Adrenalin are to be divided randomly in five groups:model control,DM model treated with low dosage, middle dosage and high dosage of Antangpill and the west medicine cross-refer respectively.

采用肾上腺素致高血糖小鼠模型和四氧嘧啶致糖尿病大鼠模型方法研究安糖片降低高血糖的作用，将实验动物随机分为五组：模型组、西药组、低剂量组、中剂量组、和高剂量组。

Both diabectic angiopathy and lipid soakage are presented in group DMCH.Conclusion It was confirmed that there was rather high rate of cholecysts stone forming in the rabbits with DM led by Alloxan,that the bile acid,phospholipid reduced and cholesterol increased in the

证实四氧嘧啶致糖尿病大耳白兔胆囊结石形成率甚高，胆囊胆汁酸分泌减少、磷脂减少和胆固醇增加形成成石胆汁，以及形成胆囊微血管病变是胆石形成的重要因素，为深入研究提供了有用的工具。

Objective To observe the effect of Fructus corni -- traditimal Chinese medicine on hyperlipoperoxide and hyposuperoxide dismutase in the sera of alloxan-induced diabetic rats.

目的：观察降糖中药山茱萸对四氧嘧啶糖尿病大鼠的高过氧化脂质和低过氧化物歧化酶的影响。

Objective: To observe the effects of Xiaokeping Jiaonang in treating the hyperglycaemia Jimpy mice which was caused by adrenaline and the rabbit of diabetes mellitus which was caused by alloxan; to explore the mechanism in blood rheology and Ang of biochemistry etc.

目的：观察消渴平胶囊对肾上腺素性高血糖小鼠以及四氧嘧啶性糖尿病家兔的治疗作用，探讨消渴平胶囊对肾上腺素引起的高血糖小鼠和四氧嘧啶性糖尿病家兔的治疗作用机制。

Results: It is showed that Xiaokeping Jiaonang is a effective prescription in treating diabetes mellitus by the experiment. The prescription could be anti- hyperglycaemia which is caused by adrenaline and increase the content of hephormone of Jimpy mice, and has positive curative effect in treating rabbit of Diabetes mellitus which is caused by alloxan by improving blood rheology and Ang of biochemistry etc.

消渴平胶囊能够对抗肾上腺素引起的小鼠高血糖，增加其肝糖原的含量；改善四氧嘧啶性糖尿病家兔的一般状况，增加体重，降低血糖，改善血液流变学，纠正脂质代谢紊乱，增强SOD的保护作用，对肾上腺素引起的高血糖小鼠和四氧嘧啶所致的糖尿病家兔具有肯定的防治疗效。

The results showed that the hypoglycaemic and the urine glucose lowering effect of PCE-C in alloxan-diabetes rabbits were excellently and long-lasting. PCE-C could also reduce the serum total cholesterol and the serum triglyceride in experimental rabbits to normal level, and delay the loss of body weight of the rabbits. The glycosylated hemoglobin is the true index that reflects the long-term controlling effect for diabetes, and the experiment result affirmed the veracity and reliability of the results of the blood glucose.

结果表明，PCE-C对实验家兔血糖和尿糖的降低效果具有高效性和持续性；当血糖控制不良时，可并发血脂水平的升高，PCE-C可以使血清总胆固醇和甘油三酯恢复正常水平，同时能减缓实验家兔的体重下降；糖化血红蛋白是真正反映糖尿病长期控制效果的指标，PCE-C对实验家兔GHb的作用影响充分证实了血糖测定结果的准确性和可靠性。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。