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To observe the therapeutic effect of dust acarid allergic vaccine NHD on patients with perennial allergic rhinitis.

目的 观察标准化尘螨变应原疫苗治疗常年性变应性鼻炎的临床疗效，并讨论其免疫学机制。

Material and MethodsRA Rabbit Model group: 15 early RA rabbits of the same weight and variety Control group:10 normal rabbits of the same weight and varietyMethods of making RA rabbit model:elect 15 normal rabbits of the same weight and variety, dissolve Ovalbumin in 0.9% sodium chloride solution, to make the solution of 20mg/ml concengtration, blend the same quantity of complete Freund′s Adjuvant equably ,inject the mixed solution into endermic tissue of the rabbit′s scapular section, making the rabbits allergic, inject 1 ml of the mixed solution to one rabbit every time, inject 1 ml of the mixed solution in 5 different places of the rabbit′s scapular section, inject the rabbit one time every week,inject 3 weeks continuously,it turned out to be that the rabbits will be allergic, inject Ovalbumin blent with the 0.9% sodium chloride solution into the knee joint cavity of the rabbits in the fourth week, 5 mg Ovalbumin every knee joint cavity,two knees of every rabbit of the 15 rabbits are both injected,the arthrosis diameter and the exterior temperature of the knees will be added obviously in 24 hours,and they will drop gradually,at the time of the 14th or 21th day, the arthrosis diameter and the exterior temperature of the knees will get to the balance time,the incidence rate of RA is 100%.after the RA model succeeds,it is the early time of RA from the first week to the fourth week,after the fourth week,it is the late time of RA, the cartilage of the femoral condyle and the subchondral bone cortices will be changed unrecoverily.

资料与方法RA模型组：早期RA家兔模型15只，品种及体重接近。对照组：正常家兔10只，品种及体重接近。RA家兔模型制作方法：选取15只成年家兔，体重、品种接近，将卵蛋白溶解于生理盐水，配成浓度为20mg/ml的溶液，与等量完全弗氏佐剂混匀，注入家兔肩胛区皮下致敏，每只家兔每次注射1ml，于肩胛区5个不同区域注射，每周一次，连续注射3周而致敏，第4周向膝关节腔注射卵蛋白生理盐水溶液，每只关节腔注射5mg卵蛋白，15只家兔膝关节全部注射，24h内此关节直径和表面温度大幅度上升，以后缓慢下降，至14～21d达到平台期，发病率达100%。造模成功后第1～4周为早期改变，第4周以后出现不可逆的关节软骨及骨破坏。采用高频超声对RA模型组与对照组的膝关节髌上囊液体厚度、滑膜及股骨髁软骨厚度及软骨下骨皮质的回声情况进行对比观察。结果RA组模型组膝关节髌上囊积液及滑膜的厚度明显厚于对照组，其股骨髁软骨的厚度与对照组相比无明显差异，其软骨下骨皮质与对照组相比无明显改变。

Objective To investigate T-bet mRNA expression on peripheral blood mononuclear cells and its relations with allergen specific IgE, eosinophile cationic protein levels, and allergic symptom in patients with allergic rhinitis.

目的 探讨变应性鼻炎患者中外周血单核细胞中T-bet mRNA的表达及其与特异性IgE、患者症状和嗜酸性粒细胞阳离子蛋白的关系。

Allergic rhinitis is an allergic reaction to something, usually pollen, dust or animal hair and occurs when allergens trigger the release of histamine and other irritating substances.

过敏性鼻炎是一种过敏性反应的东西，通常是花粉，灰尘或动物毛和时，就会发生过敏原触发释放组胺及其他刺激性物质。

Through injection, injection allergic lixivium sources, the amount of injection should be less to more, step by step, so that the body's immune function in patients with slowly adapt and fight against allergic source, reaching the ultimate effect of desensitization.

通过打针，注射过敏源的浸出液，注射的量应由少到多，循序渐进，使患者体内的免疫机能慢慢适应并对抗过敏源，达到最终脱敏的效果。

According to multivariate analyses, hospital visits due to allergic diseases were related to several fungal spores (e.g., Alternaria, Aspergillus/Penicillium, Botrytis and Drechslera/Helminthosporium) and environmental parameters (e.g., temperature, wind speed, relative humidity, PM10 and ozone ). Environmental factors also showed delayed effects on allergic diseases.

根据多变项回归模式分析结果发现，过敏性疾病就诊人次与多种真菌孢子（如Alternaria、Aspergillus/Penicillium、Botrytis、Drechslera/Helminthosporium等）、气象因子（如温度、风速、相对湿度等），以及大气污染物（如PM10、O3、THC等）有显著相关，而环境因子对过敏性疾病除了立即的影响外，亦有延迟效应。

It is necessary to strengthen safety education about drug allergy for nurses,including the meaning of drug allergy,recognizing that each drug and each medication route may has allergic reaction and drug allergy test is not the only standard to estimate drug allergy,abiding by nursing technique regulations strictly,guaranteeing the quality of drug allergy test,monitoring drug allergic reactions,recognizing the high incide...

必须对护士加强药物过敏的安全教育；不断学习和认识药物过敏的深刻意义，每一种药物和给药途径均可能发生过敏反应，药物过敏试验不是判断药物过敏的唯一标准，应走出药物过敏的误区；严格遵守护理技术操作规程，把好药物过敏试验质量关；密切观察药物过敏反应，掌握药物高度过敏反应发生的时间，早期发现不典型过敏性休克的症状；熟练掌握过敏性休克的抢救规程，病人对药物过敏的相关内容应有醒目标志。

The pathogenesis of asthma can be divided into three stages in immunology. The initial stage is sensibilization, which is closely associated with the activation of T cells. B7/CD28 and CD69 also play a significant role in this process. The second stage is chronic allergic inflammation. The immune dysfunction resulting from the disturbance of TH1/TH2 is a major cause of chronic allergic inflammation, and dominates asthma attack. And the third stage is airway remodeling due to chronic inflammation. Airway remodeling is one of the major causes of refractory asthma, which also contributes to the death from asthma.

哮喘的发病从免疫学角度可以分为三期：初期为致敏阶段，与T细胞激活关系密切，B7/CD28和CD69在这一过程也扮演重要角色；第二期为慢性过敏性炎症阶段，TH1/TH2失衡导致免疫功能紊乱是此阶段的主要原因，在哮喘发作过程中起主要作用；第三期为慢性炎症引起的气道结构重构阶段，是难治性支气管哮喘的重要发病和死亡原因。

Objective: To investigate the pathogenesis of allergic rhinitis at cell level by determing basophil histamine releasability in guinea-pigs and attempt to find an objective way for the diagnosis of allergic rhinitis.

目的：通过对变应性鼻炎豚鼠的嗜碱粒细胞释放组胺能力的测定，从细胞水平探讨变应性鼻炎的发病机制，并期望为变应性鼻炎的诊断指标提供一种客观手段。

Know that if you are allergic to nickel, you want platinum (or stay w/ 14 Kt yellow gold).

知道，如果你是对镍过敏，你想铂（或留瓦特/ 14万吨黄金）。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。