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Know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) I know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) Be, B-Boys and girls, listen up You can be anything in the world, in God we trust An architect, doctor, maybe an actress But nothing comes easy it takes much practice Like, I met a woman who's becoming a star She was very beautiful, leaving people in awe Singing songs, Lina Horn, but the younger version Hung with the wrong person Gotta astrung when I heard when Cocaine, sniffing up drugs, all in her nose Coulda died, so young, no looks ugly and old No fun cause when she reaches for hugs people hold they breath Cause she smells of corrosion and death Watch the company you keep and the crowd you bring Cause they came to do drugs and you came to sing So if you gonna be the best, I'ma tell you how Put your hands in the air And take the bell I know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) I know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) Be, B-Boys and girls, listen again This is for grown looking girls who's only ten The ones who watch videos and do what they see As cute as can be, up in the club with fake ID Careful,'fore you meet a man with HIV You can host the TV like Oprah Winfrey Whatever you decide, be careful, some men be Rapists, so act your age, don't pretend to be Older than you are, give yourself time to grow You thinking he can give you wealth, but so Young boys, you can use a lot of help, you know You thinkin life's all about smokin weed and ice You don't wanna be my age and can't read and right Begging different women for a place to sleep at night Smart boys turn to men and do whatever they wish If you believe you can achieve, then say it like this I know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) I know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) Be, be,'fore we came to this country We were kings and queens, never porch monkeys It was empires in Africa called Kush Timbuktu, where every race came to get books To learn from black teachers who taught Greeks and Romans Asian Arabs and gave them gold when Gold was converted to money it all changed Money then became empowerment for Europeans The Persian military invaded They learned about the gold, the teachings and everything sacred Africa was almost robbed naked Slavery was money, so they began making slave ships Egypt was the place that Alexander the Great went He was so shocked at the mountains with black faces Shot up they nose to impose what basically Still goes on today, you see?

f the truth is told， the youth can grow They learn to survive until they gain control Nobody says you have to be gangstas， hoes Read more learn more， change the globe Ghetto children， do your thing Hold your head up， little man， you're a king Young Prince thats when you get your wedding ring Your man is saying "She's my queen" I know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) I know I can Be what I wanna be If I work hard at it I'll be where I wanna be (I'll be where I wanna be) Save the music y'all， save the music y'all Save the music y'all， save the music y'all Save the music 我认识我能是什么我想要当如果我工作难的在它我将是我想要当的地方我认识我能是什么我想要当如果我工作难的在它我将是我想要当的地方是， B-男孩和女孩，听在你能是任何事在世界上，在上帝我们信赖一位建筑师医生，也许一个女演员但是无来容易的它拿很多练习同类，我遇到了合式的一个女人一星她非常美丽，离开敬畏的人歌唱歌， Lina 喇叭，但是年纪较小者版本和错误的人吊必须 astrung 当我听到的时候当古柯碱，在药物上面嗅，所有的在她里面鼻子 Coulda 死了，如此年轻，没有容貌丑陋和旧的没有乐趣因素当她延伸为拥抱人把握他们呼吸引起她腐蚀和死亡的味道手表公司你保存和那群众你带来引起他们开始做药物和你开始唱因此如果你去是那最好， I'ma 告诉你如何把你的手放入那空气而且拿铃我认识我能是什么我想要当如果我工作难的在它我将是我想要当的地方我认识我能是什么我想要当如果我工作难的在它我将是我想要当的地方是， B-男孩和女孩，再听这是为长大的看只是十的女孩那人手表影像而且做什么他们见到当做可爱的当做能是，向上的在那以假的身份证联合行动小心的，'在前的你会一个患有爱滋病毒的男人你能主人像 Oprah Winfrey 一样的电视无论你决定，很小心什么，一些男人是强奸者，因此行为你的年龄，做不假装当资深者超过你是，给予你自己时间生长你思考他能给予你财富，但是如此年轻的男孩，你能使用许多帮忙，你知道你 thinkin 生活所有有关 smokin 杂草和冰的事你做不想要当我的年龄和不能阅读和权利为一个地方请求不同的女人到睡眠在晚上聪明的男孩求助于男人而且做任何的他们希望如果你相信你能达成，然后发言权它同类这我认识我能是什么我想要当如果我工作难的在它我将是我想要当的地方我认识我能是什么我想要当如果我工作难的在它我将是我想要当的地方是，是，'在前的我们总计了这国家我们是国王和皇后，从不门廊猴子它在叫做 Kush 的非洲是帝国 Timbuktu，哪里每个比赛开始拿书从教希腊人的黑色老师和罗马人了解亚洲人阿拉伯人而且给予了他们黄金当黄金是转换至钱它全部改变钱然后变成了欧洲人的赋与权能波斯的军队侵入他们有学问的大约黄金、教学和每件事物神圣的非洲几乎抢夺赤裸的奴隶的身份是钱，因此他们开始赚奴隶船埃及是地方亚历山大棒者去他是如此震动在山与黑色的脸注射在他们上面鼻子强加什么基本上仍然继续进行今天，你见到？

The analysis of AL, especially ALL aneuploid, by image analysis system can be helpful in distinguishing the high risk ALL from the standard risk ALL ,and the determination of cell cycle distribution can provide a crucial reference data for chemotherapy.

图像分析系统对AL尤其是ALL异倍体的分析，有利于判断高危ALL，对细胞周期的测定给化疗个体化提供了具体的参考指标。

The intersection of the two All members is the grand sales total of all products to all customers.

两个 All 成员的交叉点就是所有客户，所有产品的销售总额。

FESTIVAL OF ALL SAINTS, also formerly known as ALL Hallows, or Hallowmas, a feast of the Catholic Church celebrated on the 1st of November in honor of all the saints, known or-unknown.

FESTIVAL OF ALL SAINTS 原来叫作ALL Hallows或Hallowmas，无论知名与否，天主教堂为了表示对所有的圣人敬意，于11月1日设盛宴进行庆祝活动。

Put all one's heart and soul to do something 常用作to do something with all one's heart and soul.比如上句就可以改写为:The most important point view of his speech was that we should work for the people with all our heart and soul.

结束语：当面临着各种挑战时，人类绝不会退缩让步，虽然SARS给我们的生存带来了极大的压力，但全世界的医务工作者们却全心全意的（put all their heart and soul to do something）扑在抗击非典的战斗中，可以说他们才是全世界最可爱的人。

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

All of the Subject-verb agreement: all of the singular and plural by its modification or refer the decision of the singular and plural nouns.

all 的主谓一致：all的单复数由它所修饰或指代的名词的单复数决定。

There were 15 pediatric ALL patients, which had received 50 times of chemotherapy with HD-MTX. The records about blood concentration of MTX and clinical conditions for 50 times chemotherapy were divided into two groups. Group I: contained 25 records of stand-risk patients, administering MTX 3.0g/m2; Group II: contained 25 records of mid and high-risk patients, administering 5.0g/m2. Continuous intravenous dripped MTX for 24th in both two groups, while implemented hydrating and alkalizing for 4 days. All patients were rescued 6 times through leucovorin, 15mg/m~2, since 12th after the end of MTX dripping. Then examined the blood concentration of MTX by fluorescence polarization immunoassay approach at 24h, 44h, 68h, at the same time inspected liver function, blood routine examination, the occurrence time and degree of toxicological reactions.

观察15例ALL住院患儿，接受大剂量MTX共50例次，按ALL危险度分2组，低危治疗组接受MTX剂量为3.0g/m2为I组；中高危治疗组接受MTX剂量为5.0g/m2为II组，连续静脉点滴MTX共24小时，同时给予水化碱化治疗，共4天，全部病例均在MTX滴注结束后12小时开始静脉推注四氢叶酸钙(leucovorin，LV)解救，15mg/m2/次，共6次，采用免疫偏振荧光法检测药物滴注24、44、68小时MTX血药浓度，同时检测两组病例的肝功、血常规，观察临床出现MTX毒副反应的时间及程度，观察每个病例毒副反应出现程度与MTX血药浓度关系，两组毒副反应程度比较，进行统计学分析。

ALA-PDT alleviated GVHD following allo-BMT and preserved GVL in ALL mice One-way mixed lymphocytes predisposed with ALA-PDT and marrow cells from the donors were infused into ALL mice. The body weight increase, haematogenesis recovery and survival time were better then all the other groups.

ALA-PDT减轻急性淋巴细胞白血病(acute lymphoblastic leukemia，ALL)小鼠同种异基因骨髓移植后GVHD反应，并且保留了GVL效应将经过ALA-PDT处理过的单向混合淋巴细胞联合供鼠的骨髓细胞输注给ALL小鼠体内，ALL受鼠的体重增长情况、造血功能恢复情况及无病生存时间等指标明显好于对照组。

I will endeavour to find you some assistance.

我尽力帮你找人帮忙。

At first I only know bruck is the idol of American younglings, afterwards I returned back to Taiwan ,even in Beijing last year ,I saw her poster everywhere, I was so surprised at her charm.

起初我只晓得布鲁克雷德丝是美国少男少女崇拜的偶像，后来回台湾，甚至去年在北京，居然也四处看见她的海报，才惊讶她的魅力之大。