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We are mature enough now to stand the shock of learning that much of what we were taught in our youth was wrong, or improperly understood by those who were teaching it, or perhaps shaded a bit, the shading resulting from the personal needs of the teachers, who as human beings had a tendency to introduce some of their heart's blood into their work, and sometimes this may not have been of the first water, this heart's blood, and even if they thought they were moving the "knowledge" out, as the Board of Education had mandated, they could have noticed that their sentences weren't having the knockdown power of the new weapons whose bullets tumble end-over-end (but it is true that we didn't have these weapons at that time) and they might have taken into account the fundamental dubiousness of their project (but all the intelligently conceived projects have been eaten up already, like the moon and the stars) leaving us, in our best clothes, with only things to do like conducting vigorous wars of attrition against our wives, who have now thoroughly come awake, and slipped into their striped bells, and pulled sweaters over their torsi, and adamantly refused to wear any bras under the sweaters, carefully explaining the political significance of this refusal to anyone who will listen, or look, but not touch, because that has nothing to do with it, so they say; leaving us, as it were, with only things to do like floating sheets of Reynolds Wrap around the room, trying to find out how many we can keep in the air at the same time, which at least gives us a sense of participation, as though we were Buddha, looking down at the mystery of your smile, which needs to be investigated, and I think I'll do that right now, while there's still enough light, if you'll sit down over there, in the best chair, and take off all your clothes, and put your feet in that electric toe caddy and slip into this permanent press hospital gown, to cover your nakedness-why, if you do all that, we'll be ready to begin!

现在我们已经足够成熟来承受学习的震撼，以此我们来嘲笑我们年轻时候的错误，或者错误地理解教我们的人，或者也许掩饰掉它，掩饰将使得我们更需要老师，他们就像人类的趋向来将他们的一些心血用在工作上，有些时候这些已经不是第一点水了，这是心血，甚至他们是在想他们把"知识"搬了出去，广泛教育形成，他们也许已经认识到他们的句子已经没有新武器的那样的震撼力了，新武器的子弹击倒了一个又一个（但是的确哪个时候我们没有那样的武器），他们也许会被考虑进基础性不确定的留给我们的项目（但是所有构思高明的项目早就被吃光了，就像星星之于月亮），在我们最好的衣服中，只有一件事情可以做，就像操纵有力的战争摩擦来反对我们的妻子一样，她正在完全醒来，滑进有斑纹的闹钟中，扯下羊毛衫，放在为完成的作品上，坚决拒绝在羊毛衫里穿任何凶罩，小心翼翼地想任何听众解释这个拒绝政治上的重大意义，或者观众，但不包括触抹者，因为这没有任何意义，所以他们说，不要管我，只有一件事情要做，就像雷诺茨？

We are mature enough now to stand the shock of learning that much of what we were taught in our youth was wrong, or improperly understood by those who were teaching it, or perhaps shaded a bit, the shading resulting from the personal needs of the teachers, who as human beings had a tendency to introduce some of their heart's blood into their work, and sometimes this may not h39e been of the first water, this heart's blood, and even if they thought they were moving the "knowledge" out, as the Board of Education had mandated, they could h39e noticed that their sentences weren't h39ing the knockdown power of the new weapons whose bullets tumble end-over-end (but it is true that we didn't h39e these weapons at that time) and they might h39e taken into account the fundamental dubiousness of their project (but all the intelligently conceived projects h39e been eaten up already, like the moon and the stars) le39ing us, in our best clothes, with only things to do like conducting vigorous wars of attrition against our wives, who h39e now thoroughly come awake, and slipped into their striped bells, and pulled sweaters over their torsi, and adamantly refused to wear any bras under the sweaters, carefully explaining the political significance of this refusal to anyone who will listen, or look, but not touch, because that has nothing to do with it, so they say; le39ing us, as it were, with only things to do like floating sheets of Reynolds Wrap around the room, trying to find out how many we can keep in the air at the same time, which at least gives us a sense of participation, as though we were Buddha, looking down at the mystery of your 56ile, which needs to be investigated, and I think I'll do that right now, while there's still enough light, if you'll sit down over there, in the best chair, and take off all your clothes, and put your feet in that electric toe caddy and slip into this permanent press hospital gown, to cover your nakedness-why, if you do all that, we'll be ready to begin!

现在我们已经足够成熟来承受学习的震撼，以此我们来嘲笑我们年轻时候的错误，或者错误地理解教我们的人，或者也许掩饰掉它，掩饰将使得我们更需要老师，他们就像人类的趋向来将他们的一些心血用在工作上，有些时候这些已经不是第一点水了，这是心血，甚至他们是在想他们把"知识"搬了出去，广泛教育形成，他们也许已经认识到他们的句子已经没有新武器的那样的震撼力了，新武器的子弹击倒了一个又一个（但是的确哪个时候我们没有那样的武器），他们也许会被考虑进基础性不确定的留给我们的项目（但是所有构思高明的项目早就被吃光了，就像星星之于月亮），在我们最好的衣服中，只有一件事情可以做，就像操纵有力的战争摩擦来反对我们的妻子一样，她正在完全醒来，滑进有斑纹的闹钟中，扯下羊毛衫，放在为完成的作品上，坚决拒绝在羊毛衫里穿任何凶罩，小心翼翼地想任何听众解释这个拒绝政治上的重大意义，或者观众，但不包括触抹者，因为这没有任何意义，所以他们说，不要管我，只有一件事情要做，就像雷诺茨？

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and whatnot; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水；我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏；我爱撒出的热呼呼的尿和久治不愈的淋病；我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像；我爱亚马逊河和奥里诺科河这样的大河，那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说，淹死在瞎眼的河口中；我爱流动的一切，甚至爱女人来月经时流出的血，它冲走了生育能力不强的精子；我爱会流动的手稿，不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的；我爱流动的一切，一切其中有时间的和适当的东西，它们把我们带回永远不会结束的开始中，即先知们激烈、令人狂喜的猥亵，宗教狂的智慧，牧师和他的橡皮连祷文，妓女的下流话，从排水道里漂走的唾液，乳房里的奶汁和子宫里流出的带苦味的蜜水，以及一切流质的、溶化的、放荡的和有溶解力的，所有在流动中得到静化的脓和脏物，那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and what not; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水；我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏；我爱撒出的热呼呼的尿和久治不愈的淋病；我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像；我爱亚马逊河和奥里诺科河这样的大河，那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说，淹死在瞎眼的河口中；我爱流动的一切，甚至爱女人来月经时流出的血，它冲走了生育能力不强的精子；我爱会流动的手稿，不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的；我爱流动的一切，一切其中有时间的和适当的东西，它们把我们带回永远不会结束的开始中，即先知们激烈、令人狂喜的猥亵，宗教狂的智慧，牧师和他的橡皮连祷文，妓女的下流话，从排水道里漂走的唾液，***里的奶汁和子宫里流出的带苦味的蜜水，以及一切流质的、溶化的、放荡的和有溶解力的，所有在流动中得到静化的脓和脏物，那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

You said that your own family would be only too delighted to pay all the necessary costs: that your father had been an incubus to them all : that they had often discussed the possibility of getting him put into a lunatic asylum so as to keep him out of the way: that he was a daily source of annoyance and distress to your mother and to everyone else: that if I would only come forward to have him shut up I would be regarded by the family as their champion and their benefactor: and that your mother's rich relations themselves would look on it as a real delight to be allowed to pay all costs and expenses that might be incurred in any such effort.

当我告诉律师我没钱支付这巨额费用时，你马上提出，说你自己家里将很乐意支付所有的费用，说你父亲是你们大家的祸害，你们常常商量是不是把他送疯人院了事，说你父亲成天弄得你母亲还有别的人不得安生，如果我能为你们出头，让他就范，那全家人就会把我当作英雄和恩人，而你母亲有钱的亲戚朋友会因为允许他们代为偿付此举的一切费用而满心欢喜。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and what not; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水；我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏；我爱撒出的热呼呼的尿和久治不愈的淋病；我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像；我爱亚马逊河和奥里诺科河这样的大河，那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说，淹死在瞎眼的河口中；我爱流动的一切，甚至爱女人来月经时流出的血，它冲走了生育能力不强的精子；我爱会流动的手稿，不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的；我爱流动的一切，一切其中有时间的和适当的东西，它们把我们带回永远不会结束的开始中，即先知们激烈、令人狂喜的猥亵，宗教狂的智慧，牧师和他的橡皮连祷文，妓女的下流话，从排水道里漂走的唾液，乳房里的奶汁和子宫里流出的带苦味的蜜水，以及一切流质的、溶化的、放荡的和有溶解力的，所有在流动中得到静化的脓和脏物，那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and whatnot; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水；我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏；我爱撒出的热呼呼的尿和久治不愈的淋病；我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像；我爱亚马逊河和奥里诺科河这样的大河，那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说，淹死在瞎眼的河口中；我爱流动的一切，甚至爱女人来月经时流出的血，它冲走了生育能力不强的精子；我爱会流动的手稿，不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的；我爱流动的一切，一切其中有时间的和适当的东西，它们把我们带回永远不会结束的开始中，即先知们激烈、令人狂喜的猥亵，宗教狂的智慧，牧师和他的橡皮连祷文，妓女的下流话，从排水道里漂走的唾液，***里的奶汁和子宫里流出的带苦味的蜜水，以及一切流质的、溶化的、放荡的和有溶解力的，所有在流动中得到静化的脓和脏物，那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

All Christians believe that the blessed are the poor and humble, and those who are ill-used by the world; that it is easier for a camel to pass through the eye of a needle than for a rich man to enter the kingdom of heaven; that they should judge not, lest they be judged; that they should swear not at all; that they should love their neighbour as themselves; that if one take their cloak, they should give him their coat also; that they should take no thought for the morrow; that if they would be perfect, they should sell all that they have and give it to the poor.

一切基督教徒都相信，上帝所赐福的乃是穷人、贱人和被世人恶待的人；他们都相信，富人要进入天国比骆驼要穿过针孔还困难；他们都相信，他们不应有所裁判，否则他们就应受到裁判；他们都相信，他们绝对不应指神发誓；他们都相信，他们应当爱邻如爱己；他们都相信，假如有人要拿他们的罩袍，他们就应把自己的上衣也送给他；他们都相信，他们应当不思虑到明天；他们都相信，如果他们要成为完善，就应当卖尽自己所有的一切并散给穷人。

Like a cat I slumber, blissfully unencumbered,Through eighty per cent of my allotted span,Occasionally awoken, when dissent is spoken,And I invent another cunning five year plan,Lately it was pensions, that were being mentioned,So I borrowed from the French and Robespierre,Scrap all that went before, saved by tooth and claw,And let my all equal Citizens appear,Currently it is time, for me to be in my prime,For there is another election looming,I have to appear sincere, for part of this coming year,And assure everyone that everything is booming,Never mind strict quotas, Ive imported multitudes of voters,And told them which party let them stay,Though Ive rigged the postal vote, and defamed everyone of note,You never know what might happen on the day.So to be on the safe side, I swallow all my pride,And allow my people to hear my hallowed voice,And roll out the charade, put on the facade,And even make believe they have a choice,Next time around the crown, will be trampled underground,House of Lords and Lord Chancellor history,With the other Chancellor gone, I alone will soldier on,Yes, then there will only ever be me,Ill hold elections for you, as all dictators do,And fill positions with those that grease my palm,As for civil unrest, there is always house arrest,Or secret imprisonment for those that mean me harm.

像一只猫，我沉睡后，开心的支配，通过80%分配给我国跨度，偶尔醒来，当异议言，我发明的另一狡猾五年计划，最近有人养老金又被提及，所以我借鉴了法国和罗伯斯庇尔，放弃一切，来到之前，省下的牙齿和爪，让我的所有公民一律平等看来，目前已经是时候了，我将在我首要的，还有大选在即，我要真诚地出现，对于这部分来年，向大家保证，万事蓬勃，别说严配额学院引进众多选民，并告诉他们是哪一方，让他们留下来，虽然学院造邮递投票污蔑和大家注意，你永远不知道会发生什么就day.so为了安全方我吞下一切，我感到很自豪，让我的人民听到我的声音繁文缛节，并推出了夏利，放在门面，甚至相信他们有一个选择，下次周围冠将地下践踏，上议院大法官史，与其他校长了，我会独自士兵不错，便只有永远的是我，生病举行选举，为您由于所有独裁者做，填补那些油脂我手掌，至于内乱，总是有软禁，或秘密监禁那些意味着我的伤害。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。