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Therefore, with the approval of the sacred Lateran council, by apostolic authority and fullness of power, we approve and renew, and order to be observed and maintained in their totality and without change, the said letter together with each and every statute, ordinance, decree, explanation, agreement, compact, promise, wish, penalty, restraint and clause contained in it; especially the clause by which it was our will that if the said king of France does not approve and ratify the aforesaid letter, and each and every thing contained in it, within six months from the date of this present letter, and does not arrange for the contents to be read, published, sworn to and registered, like all other royal constitutions in his kingdom and in all other places and lordships of the said kingdom, for all future time without limit, by all the prelates and other ecclesiastical persons and courts of parlements, and if he does not convey to us, within the said six months, letters patent or authentic written documents concerning each and all of the aforesaid matters about the acceptance, reading, publication, oath and registration referred to, or does not deliver them to our nuncio attached to the king, in order to be passed on by him to us, and does not subsequently arrange for the letter to be read each year and effectively observed without alteration exactly as other binding constitutions and ordinances of the king of France have to be observed, then the letter itself and whatever follows from it are null and void and of no force or value .

因此，在徵得安理会的神圣拉特兰，由使徒的权威和充实力量，我们赞成和更新，并以得到遵守和维护他们的整体，没有变化，该信连同每一个章程，条例，法令解释，协议，契约，承诺，希望，罚款，限制和条款，载於它；特别是其中的条款，这是我们的意志，如果说法国国王不同意和批准上述信件，和每一个事载於它，在6个月内之日起的本信，并没有安排的内容来阅读，出版，发誓要和登记，象所有其他王国的宪法，他在英国和其他所有的地方和lordships英国的说，今后所有的时间没有限制，所有的主教和其他教会人员和法院parlements ，如果他不转达给我们，在上述6个月，英皇制诰或真实的书面文件和所有的每一个上述事项的接受，阅读，出版，宣誓和注册提到，或者没有交给我们的大使重视国王，以便通过他给我们，并没有随后安排信每年读和有效地观察到完全没有改变的其他具有约束力的宪法和法令的法国国王都必须遵守，那麼，这封信本身，无论从它是无效的，没有武力或价值。

This acquaints with to be like a beautiful love story,Because all in the conjecture, is but affection a little of is stir up, because of to faraway of she remember fondly, gradual of to the girl friend in the reality,Lost patience, excessive of the inhospitality make the girl friend in the reality a sad, but I am in April 5, 06 years and game of she, at admire the Er guest accept the star river of virtuous neighborhood a cabaret an appointment,The first eye, my knows that she once got married, just be like all unfortunate marriages before meet, husband with another woman together, drive totally 2 times all she discovered and I love her very much,When see she sleep soundly in my bosom of time, I tell myself, I want to the good lifetime of this woman, and she also gives me be much commitment, so we open happy together spend of the heart 3 day, turn an eye to respectively go home, continue network game, continue we thus of affection, all of the happiness keep company with us, in the center also have a small antinomy,Can I with the relation of the girl friend in the reality but more and more far, until she puts forward break up, at July 30, my in the mind unspeakable felling, feel at that time for the sake of if son I only not turn head,Finally on September 8 we another time met, and we are also same this time the cabaret was happy to spend at the star river for 4 days, can time change, the girl friend in the reality now then but be get married, but if the son be missing my commitment, to I only chilly hurt my words, afterwards I just know, she and her husband match like, ha ha

却越来越远，直到她提出分手，在7月30日，我心里说不出的感觉，当时觉得为了若儿我只有不去回头了，终于在9月8日我们又一次见面了，而这次我们也同样在星河酒店开心度过了4天的时间，可时间转变，现实里的女朋友而今却要结婚了，而若儿对我的承诺都不见了，对我只有冷冷的伤害我的话，后来我才知道，她和她老公合好了，呵呵

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

One Of Us They passed me by, all of those great romances You were, I felt, robbing me of my rightful chances My picture clear, everything seemed so easy And so I dealt you the blow One of us had to go Now it's different, I want you to know One of us is crying One of us is lying In her lonely bed Staring at the ceiling Wishing she was somewhere else instead One of us is lonely One of us is only Waiting for a call Sorry for herself, feeling stupid feeling small Wishing she had never left at all I saw myself as a concealed attraction I felt you kept me away from the heat and the action Just like a child, stubborn and misconceiving That's how I started the show One of us had to go Now I've changed and I want you to know One of us is crying One of us is lying In her lonely bed Staring at the ceiling Wishing she was somewhere else instead One of us is lonely One of us is only Waiting for a call Sorry for herself, feeling stupid feeling small Wishing she had never left at all Never left at all Staring at the ceiling Wishing she was somewhere else instead One of us is lonely One of us is only Waiting for a call

我们其中之一他们让我通过，所有那些重大的浪漫史我感觉，你是剥夺我的公正机会我的画很清除，一切看起来这样容易的所以我给予你打击我们其中一个必须走我想要你知道，现在已经不同了我们其中一个在哭泣我们其中一个在说谎在她孤独的床凝视天花板希望她倒是在别的地方我们其中一个是孤独的我们其中一个只是等侯一个电话对自己感到遗憾，觉得愚蠢觉得渺小希望她没有完全离去我把我自己视作一个被隐藏的吸引我觉得你离开热度和行动的我就像一个孩子一样，顽固和误解那就是如何我开始展览会我们其中一个必须去现在我改变了想法，我想要你知道我们其中一个在哭泣我们其中一个在说谎在她的孤独的床凝视天花板希望她倒是在别的地方我们其中一个是孤独的我们其中一个只是等侯一个电话对自己感到遗憾，觉得愚蠢觉得渺小希望她没有完全离去了没有完全离去凝视天花板希望她倒是在别的地方我们其中一个是孤独的我们其中一个只是等侯一个电话

Let us not weary of repeating, and sympathetic souls must not forget that this is the first of fraternal obligations, and selfish hearts must understand that the first of political necessities consists in thinking first of all of the disinherited and sorrowing throngs, in solacing, airing, enlightening, loving them, in enlarging their horizon to a magnificent extent, in lavishing upon them education in every form, in offering them the example of labor, never the example of idleness, in diminishing the individual burden by enlarging the notion of the universal aim, in setting a limit to poverty without setting a limit to wealth, in creating vast fields of public and popular activity, in having, like Briareus, a hundred hands to extend in all directions to the oppressed and the feeble, in employing the collective power for that grand duty of opening workshops for all arms, schools for all aptitudes, and laboratories for all degrees of intelligence, in augmenting salaries, diminishing trouble, balancing what should be and what is, that is to say, in proportioning enjoyment to effort and a glut to need; in a word, in evolving from the social apparatus more light and more comfort for the benefit of those who suffer and those who are ignorant.

我们应当不厌其烦地反复提出：要最先想到那些没有生计的痛苦民众，为他们减少困难，让他们得到空气和光明，爱护他们，扩大他们的视野，使他们感到灿烂辉煌，用种种形式为他们提供接受教育的机会，为他们提供劳动的榜样，而不是游手好闲的榜样，减轻他们个人负担的压力，增加他们对总目标的认识，限制穷困而不限制财富，大量创造人民共同劳动的天地，象布里亚柔斯①那样，把一百只手从四面八方伸向受压迫和软弱无力的人，为这一伟大职责运用集体的力量，为所有的胳膊开设工厂，为所有的才能开办学校，为所有的智力设立实验室，增加工资，减轻惩罚，平衡收支，也就是说，调整福利与劳动之间和享用与需求之间的比重。总之，要使社会机器为受苦和无知的人的利益发出更多的光明和更多的温暖，使富于同情心的人不忘记这些，这是人间友爱的第一义务，使自私自利的人懂得这些，这是政治的第一需要。①布里亚柔斯，神话中的巨人，是天和地的儿子，有五十个头和一百只手。

All of us have secrets All of us wander at times All of us have faith that wavers All of us at time feel inadequate That is why all of us need something more than us.

今天与大家分享的是，酷酷的口语，绝对简单，也绝对通俗，一定要记住哦！

You BE Evolution incompletely of life body, gene mutation of Alien, The senior high school of kindergarten degree living, inborn Mongolia the frog head of disease, The abandoned baby of Mount Everest snow man, the septic tank stop of murderer, The Africa make top black*of descendant, the yin and yang out of tune chimpanzee, The hippo been ran over by the Noah's ark, new volcano eruption, Super big shameless transmit sound to expand a sound trumpet, the humiliation of the Eskimo, With cockroach coexistence live of super individual, the vitality putrefied half plant, Will send out bad smell of**person,"cast off" the source head of word, Everyday deteriorate three time dinosaur, mankind history top most strongly discard a material, God lose the old washer which fall off, ability thinking of have no head living creature, Damage the disaster of compatriot fame in Asia, the ancestry receive for it abashed of descendant, The Fu of deposition thousand years plant quality, the scientist also dare not a research of originality species, The deposition raw material of 1000% petroleum densities, is disfigure of McDonald's uncle, Be like your this kind of damned guy: Only one Tuo muck that can play the inside of the television drama, Canned not compare with a wayside the chewing gum be spread urine by the dog, Connect such as flower all handsome you 1000% above, Seek the girl friend get to even want to leave the Earth to the zoo, Wanting to commit suicide would someone advise you and don't leave corpse in order to prevent a pollution environment, You once touched of keyboard top connect rice the protozoa all live not bottom go to, Jet come of the saliva return than the SARS fatal, Pack the lovely words can the moment solve population inflation of problem, Play cool pack handsome words mankind to have to use asexual reproduction, The idiocy can be you of teacher, mentally retarded can teach you how to say person's words, Want ～only your rise ozone layer meeting hole Wanting to immigrate Mars is in order to leave you, If you of ugly can generate electricity of the nuclear power station of words whole world can be with the lockout, The words bullet missile fight would be unbearable to fly toward you, The hand grenade see you would from explode, Other people would not° until open an airplane to bump a pair of son star line but you as long as bail out and then have same of power, All of the famous spot that you have been to change historic monument, you have been to of the historic monument will become history, 18 generation son all have no stem good matter would understanding you, connect throw into the sun all suspicion not enough environmental protection Anyway horizontal Shu a words:Don't let me see you again, if saw you, I must put out you!

你是 进化不完全的生命体，基因突变的外星人，幼稚园程度的高中生，先天蒙古症的青蛙头，圣母峰雪人的弃婴，化粪池堵塞的凶手，非洲人搞上黑*的后裔，阴阳失调的黑猩猩，被诺亚方舟压过的河马，新火山喷发口，超大无耻传声扩音喇叭，爱斯基摩人的耻辱，和蟑螂共存活的超个体，生命力腐烂的半植物，会发出臭味的**人，&唾弃&名词的源头，每天退化三次的恐龙，人类历史上最强的废材，上帝失手摔下来的旧洗衣机，能思考的无脑袋生物，损毁亚洲同胞名声的祸害，祖先为之蒙羞的子孙，沉积千年的腐植质，科学家也不敢研究的原始物种， 10倍石油浓度的沉积原料，被毁容的麦当劳叔叔，像你这种可恶的家伙：只能演电视剧里的一陀粪，比不上路边被狗洒过尿的口香糖，连如花都帅你10倍以上，找女朋友得去动物园甚至要离开地球，想要自杀只会有人劝你不要留下尸体以免污染环境，你摸过的键盘上连阿米吧原虫都活不下去，喷出来的口水比SARS还致命，装可爱的话可以瞬间解决人口膨胀的问题，耍酷装帅的话人类就只得用无性生殖，白痴可以当你的老师，智障都可以教你说人话，只要你抬头臭氧层就会破洞要移民火星是为了要离开你，如果你的丑陋可以发电的话全世界的核电厂都可以停摆，去打仗的话子弹飞弹会忍不住向你飞，手榴弹看到你会自爆，别人要开飞机去撞双子星才行而你只要跳伞就有同样的威力，你去过的名胜全部变古迹，你去过的古迹会变成历史， 18辈子都没干好事才会认识你，连丢进太阳都嫌不够环保反正横竖一句话：别让我再看见你，要是见着了你，我一定要把你灭了！

Back in 2003-2004, we had all the throwbacks and all the Nike shoes and I think we were looking at what was current with these players, and this year we're doing a big overhaul on all of the player models, all of the faces, and we want to be really accurate with all of the sneakers these guys are wearing so we can feed into the lifestyle and culture of the game.

早在2003年至2004年，我们的一切throwbacks ，所有的耐克鞋，我想我们正在寻找什么是当前的这些球员，今年我们正在做的一个大检修的所有播放器型号，所有的面临，我们要真正准确的所有运动鞋穿着这些家伙，让我们可以馈入的生活方式和文化的游戏。

I am most dear L You took me into the seat A Midsummer Night's Dream Only you A pupil of the eye and smile all the world to do with desolation Bright also move the entire hall Is the memory of that A bow Zhang Yi Tai He Yan - I thought It was alleged in the A smile A frown A Diyin A shallow sing A little bit of mottled shadow, for some of the yellowing paragraph in the past Block is a dump destroyed the city wall Or a tie game time This has been like to go on This has been watching you L As with all of the time became the music of the 12 Piaofei In this letter, Play the most beautiful movement All of the notes, where solidification In the slender your fingertips In your hair soft, In it you tired yet bright vision In it you take it lightly but a lot of sincere hand My dear L You see, The accumulation of sweets on the table is not less than the touch heaven A person behind it is not always empty picture At the end of the world it really does not cross the wall in the past In the end it is only a direction too far The sorrow of so many suffering So much of a loss Dihui After all, only in the past of injury Dear I promise After a good smile No longer sad

我最最亲爱的L 是你带我走进了这席仲夏夜之梦也唯有你一眸一笑都带尽了人世苍凉一举一动亦明亮了整个厅堂是记忆中的那一低头一抬掌一阖眼一思量还是那臆想中的一微笑一皱眉一低吟一浅唱一点点斑驳的影子，一段段泛黄的过往是一座座倾圮的城墙抑或是一场场饕餮的时光想这样一直下去一直这样看着你 L 如同所有时光化成了十二张飘飞的乐谱在这个字母上奏出了最华丽的乐章所有的音符凝固在那里在你那修长的指尖在你那柔软的发梢在你那疲惫而不失明亮的眼光在你那淡然却不少真挚的手掌我亲爱的L 你看桌上堆积的甜食并非是触及不到的天堂一个人的背后也并非总是空荡荡的景象世界的尽头是否真的有跨不过去的高墙那终究只是一个太远的方向那么多的悲哀痛苦那么多的低回彷徨终究都只是过往的伤亲爱的答应我以后好好微笑不再悲伤。。。。。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。