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Thus, it may serve as a novel target for the treatment of various skin disorders. Clinically, PPARgamma agonists have been used to treat psoriasis, psoriatic arthritis, atopic dermatitis, melanoma, hirsutism, vascular tumors and lipodystrophy.

临床上过氧化物酶体增殖因子活化受体γ激动剂已被试用于银屑病、银屑病性关节炎、特应性皮炎、黑素瘤、多毛症、血管肿瘤和脂肪营养不良等。

Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain 2000;86:185-194.[16]Knox RJ, Isaac L. Effects of selective and non-selective kappa-opioid receptor agonists on cutaneous C-fiber-evoked responses of rat dorsal horn neurons.

在慢性炎症及神经损伤或过敏等引起的伤害性感受中，大量的Dyn A生成，通过NMDA 受体直接或间接地产生一些炎性介质或细胞因子，从而加强神经病理性疼痛的形成，其作用机制有待于我们进一步去探讨。

In a voluntary cervical motion, the neuromotor control exercised by the central nervous system determines the time, intensity, and a nature of excitation of agonists and antagonist muscles.

在颈椎主动运动的过程中，由中枢神经所支配的神经运动取决于主动肌和拮抗肌刺激反应的时间和紧张程度。

The fully inhibited AMP-induced neutrophilia with residual hypoxaemia observed after salbutamol is likely related to beta-agonists acting on both bronchial and pulmonary circulations.

但这些变化都可被沙丁胺醇完全抑制，作者认为这可能是因为β激动剂能同时作用于支气管和肺循环两方面。

Th e agonists and/or antagonists may be employed in a composition with a pharmaceutically acceptable carrier, e.g., as hereinafter described.

激动剂和/或拮抗剂可与药物可接受载体例如本文描述的载体组合在组合物中使用。

Moreoer, c-Fos and phospho–c-Jun protein expression was inhibited by PPARα agonists, indicating that PPARα ligands suppress OPN expression through negatie cross talk with AP-1–dependent transactiation of the OPN promoter.

另外，c-Fos及磷酸化c-Jun蛋白表达可被PPARα激动剂抑制，说明PPARα配体通过OPN启动子AP-1依赖型转录激活的负交互作用而抑制OPN表达。

Before application of agonists, preapplication of L-NNA ,a NOS antagonist no current changes could be monitored.

预加NG-硝基-L-精氨酸，再加上述激动剂，电流无变化。

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

本发明涉及含有连接在5元杂环上的稠合至环烷基或者杂环的苯基或者吡啶基环的二环化合物，包括其药学上可接受的盐和前药，它们是G蛋白偶联受体40(GPR40)激动剂并且可以用作治疗性化合物，特别是在2型糖尿病和与这些疾病相关的症状中用作治疗性化合物，这些症状包括肥胖病和脂质疾病，比如混合或者糖尿病型血脂异常症、血脂质过多、高胆甾醇血和高甘油三酯血症。

The classification was based on respiratory symptoms, spirometric results, atopy, and fraction of exhaled nitric oxide values and response to inhaled beta(2)-agonists.

分类依据包括呼吸道症状、肺活量测定结果、遗传性过敏症以及呼出气一氧化氮的浓度值和对β（2）受体激动剂的反应。

A respiratory specialist, blind to the test results, classified all 238 subjects with respect to the presence of asthma. The classification was based on respiratory symptoms, spirometric results, atopy, and fraction of exhaled nitric oxide values and response to inhaled beta(2)-agonists.

根据其哮喘表现情况，即：呼吸道症状、肺活量测定结果、特应性和呼气中一氧化氮分数以及对吸入性β2受体激动剂的反应特点，呼吸科专家将该238例受试者进行分组。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。