查询词典 agonist

PPAR γ agonist displayed obvious renoprotective action,the mechanism was complicated, it could improve the metabolism of glucose ang lipid, depress blood preasure, protect small vessels endothelium,improve the system activity of blood clotting and fibronolysis, antiinflammation, otherwise the action was more obvious with the time passed, at the early stage the effective was better,so encourage the patients to take the medicine earily; when the patients with the mediate reanl function failure, Avandia did not display significantly renoprotective action, side reaction had no difference compared to the control group,was not necessary to regulate the dose of Avandia.But because of the sample size was small, we needed a biger sample to confirm the results. We confirmed that Prol2Ala had no difference in control case,diabetic nephropathy group and diabete group,In diabetic group and diabetic nephropathy group, Ala carriers compared to noncarrier all kinds of biochemical indicators were not different,Prol2Ala did not have association with diabete and diabetic nephropathy. But because of the sample size was small, weneeded a biger sample to confirm the results.

PPARγ激动剂对糖尿病肾病具有明显的保护作用，保护作用的机制是多方面的，除了改善糖脂代谢，降低血压外，还具有保护小血管内皮，改善凝血和纤溶系统活性，抗炎症等多方面的作用，且作用随着用药时间的延长而日趋明显，在疾病的早期应用效果更佳，故提倡早期用药；对伴有慢性肾功不全的患者，罗格列酮对肾脏靶器官的保护作用显现的并不明显，但副作用与对照组无明显差异，不用根据肾功情况调整用药，但由于样本量较小，上述结论尚需大样本进行进一步证实；本实验研究得出Prol2Ala变异在健康对照组、糖尿病组及糖尿病肾病组均无显著差异，糖尿病组及糖尿病肾病组临床各生化指标与Prol2Ala变异亦无相关性，Prol2Ala与糖尿病及糖尿病肾病不相关。

We summarize disease-related changes in TRPV1 expression and its implications for therapy and potential adverse effects. Last, we provide an overview of the current clinical uses of topical and injectable TRPV1 agonist preparations in both oncologic and nononcologic populations.

总结TRPV1与疾病相关的表达变化及其在治疗和潜在副作用中的意义，并且概括目前经典疗法和注射TRPV1激动剂疗法在肿瘤患者和非肿瘤群体中的临床应用。

Of the 32 cases,26 underwent bilateral orchiectomy before radiotherapy, l case received emasculation by radiotherapy and 5 cases by luteinizing hormone-releasing hormone agonist.

内分泌治疗采用去势加抗雄激素治疗的联合雄激素阻断治疗，26例放射治疗前接受双侧睾丸切除，1例行睾丸放疗去势，5例应用抑那通药物去势。

The present invention discloses novel aryl oxazole compounds of Formula I, or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds.

本发明公开了式的新型芳基唑化合物或其药学可接受盐，其具有组胺H3受体拮抗剂或反向激动剂活性，本发明还公开了制备和使用这类化合物的方法。

However, this agonist at the spinal site may cause direct inhibition of the sacral preganglionic neuron discharge, and then inhibit the pelvic nerve activity.

然而，当此药物直接作用在脊髓部位时，却会直接影响到副交成神经节前神经元之活性，因此对骨盆神经之活性造成抑制。

A monolayer culture system of pituitary cells was used to study the release of LH and FSH and their responses to a GnRH agonist,LRH-A3,in vitro by pituitary cells of prepubertal gilts at the ages of 30,60,90,120,and 150 days.

利用垂体细胞单层培养模型研究了30，60，90，120和150日龄北京黑猪母猪垂体细胞LH和FSH的释放及其对LRH-A3反应能力。

METHODS: We developed a fully major histocompatibility complex-mismatched murine BMT model without systemic graft-versus-host disease, and challenged mice with aerosolized lipopolysaccharide, a prototypic TLR4 agonist, to determine the effect upon pulmonary alloimmune lung injury.

我们制作了无全身移植物抗宿主反应的全主要组织相容性抗原错配的小鼠BMT模型，并对其采用雾化脂多糖（一种TLR4激动剂）吸入明确同种免疫肺损伤的作用。

The results showed that in skin trauma and combined radiation-impaired wound models, CGS21680 (agonist of the A2A recaptor) promoted while A2A gene knock-out delayed the course of skin wound healing.

结果表明，CGS21680促进外周组织伤口的愈合，却加重颅脑创伤模型的神经功能损害，这与其促进谷氨酸释放有关。

In the middle rostrocaudal third of the red nucleus,the double-labelled neurons mainly occupied the ventromedial portions of the red nucleus.Injection of Bay K8644 (an L-Ca2+ channel agonist) in lateral ventricle induced immunoreactive intensity and did not change the distribution pattern of CaBP-LI positive rubrospinal neurons.

脑室注射L型钙离子通道激动剂Bay K8644 仅引起CaBP-LI免疫反应强度增加，并未改变两种神经元的分布方式，头侧CB-Au标认的红核-脊髓投射神经元仍表现CaBP-LI阴性。

Injection of Bay K8644 (an L-Ca2+ channel agonist) in lateral ventricle induced immunoreactive intensity and did not change the distribution pattern of CaBP-LI positive rubrospinal neurons.Rubrospinal neurons in the rostral portion still showed CaBP-LI negative.

脑室注射L型钙离子通道激动剂Bay K8644 仅引起CaBP-LI 免疫孕妇反应强度增加，并未改变两种成年人神经元的分布方式，头侧CB-Au标认的红核-脊髓投射成年人神经元仍表现CaBP-LI阴性。

As of Tuesday, Google's results were still censored in China.

截至周二，谷歌的搜索结果仍受中国审查。

In order to make the positive action increase and negative one decrease, the sub-forces of the social factors must be adjusted to form a centripetal force.

在这一过程中，人的主体性发挥是社会有机体健康发展的灵魂。