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Aim: To determine whether activation of κ-opioid receptor with U50,4 88 H, a selective κ-opioid receptor agonist, produces any changes in electrical u ncoupling during prolonged ischemia and whether these changes in electrical unco upling is associated with the cardioprotection induced by κ-opioid receptor ac tivation, and to explore the possible mechanism.

测量指标：以分光光度计在490nm波长下测定氯化三苯基四氯唑与活细胞反应的产物formazan含量的方法测定心肌细胞活性、测定冠脉流出液中乳酸脱氢酶的含量以及心室内压；②全心停灌70min，应用四电极法观察不同浓度U50，488H、nor-BNI和5-HD对缺血期间心肌整体阻抗和电脱耦联参数(电脱耦联时间、平台时间、电脱耦联最大速率和阻抗倍数)的影响。

Six hours after exposure, vasomotor and fibrinolytic function were assessed by means of intraarterial agonist infusions.

吸入汽车废气后6小时，通过输入动脉激动剂药物分析血管收缩和溶解纤维蛋白的功能。

The results showed that UK14300 3×10~(-6 mol/L, a potent #alpha#_(2)-adrenoceptor agonist,significantly inhibited both basal and endotoxin-induced CGRP release by 22%-42%,while specific antagonist of #alpha#_(2)-adrenoceptor yohimbine 10~(-5 mol/L blocked the effect of UK14304 completely.

结果发现，α_(2)-受体激动剂UK143043×10~(-6mol／L可以显著抑制CGRP的基础释放和内毒素(1～5μg／ml)刺激后的释放，抑制幅度为22％～42％；用α2-受体拮抗剂Yohimbine(10－5mol／L)可以完全阻断UK14304的作用。

Binding of the P2Y12 receptor by its agonist, ADP, activates the G-protein inhibitor secondary messenger system, which, through a complex series of events, mediates the completion and amplification of the aggregatory response.7 Ticlopidine and clopidogrel are prodrugs that are converted to an active metabolite through a 2-step process mediated by the hepatic cytochrome ...

氯吡格雷和抵克立得作为药物前体，都可通过肝脏细胞色素P450介导的两步反应过程转化为活性代谢物…。。

It has been well established that agmatine is an endogenous agonist at imidazoline receptors and noncatecholamine ligand at alpha - 2 adrenergic receptors (α2- AR).

业已证明，胍丁胺是一种内源性的咪唑啉受体激动剂和α2-肾上腺素能受体（α2-AR）的非儿茶酚胺配基。

Objective The experiment studied the effects of acetylcholine and M-receptor agonist pilocarpine on the electric activities of the pain-related neurons in the locus ceruleus of normal rats,in order to further study the role and the interaction of ACh and LC in the modulation in the algetic sense.

目的 本实验观察大鼠侧脑室内加入外源性乙酰胆碱后，蓝斑核（Locus ceruleus，LC）痛反应神经元的电变化，以及M受体激动剂毛果芸香碱的激动效应，进一步研究ACh和LC在痛觉调制中的作用及其相互关系。

The infusion of DADLE, a δ-opioid receptor agonist, produced a dose-dependent increase of ARNA without affecting renal pelvic substance P release, urine flow rate, and urinary sodium excretion.

此外，从肾盂灌注类鸦片致效剂DADLE([D-Ala2， D-Leu5]-enkephalin)，则会有一浓度依存性的增加ARNA的活性，但却不会影响肾盂内物质P的释放及对侧肾脏尿液流速(urine flow rate， UV)和钠离子排泄率(urinary sodium excretion， UNaV)；而此ARNA的增加并不会因预先给予NK-1受体拮抗剂spantide I (0.1mg/ml， 20μl/min)而有所减少。

Based on the synthesis method and the function of decreasing blood glucose levels of rosiglitazone, and the report on benzoquinones which resulted in a significant decrease in blood glucose levels, a novel non-thiazolidinedione class of PPARy agonist 2, 5-Dihydroxy-3-{4-[2-(methyl- pyridin-2- yl-amino)- ethoxy] -phenyl}-6-phenyl-[l, 4] benzoquinone (4) was designed and synthesized.

在合成罗格列酮的基础上，根据某些醌类结构化合物的类似胰岛素作用，设计并合成了一种非噻唑烷二酮类PPARγ激动剂2，5-二羟基3-{4-[2-(甲基-2-吡啶氨基)-乙氧基]-苯基}-6-苯基-1，4苯醌(4)。

Most recently, incensole acetate was isolated from Boswellia carterii and shown to be a potent TRPV3 agonist and cause anxiolytic-like and antidepressive-like behavioral effects in mice with concomitant changes in brain c-Fos activation, a marker for changes in neuronal activity.

上图为常用的制香原料，从上到下，从左至右，为：抹香，冰片，苏门答腊安息香胶，阿曼乳香，Guggul，黄金乳香，妥鲁香，索马里没药，劳丹脂，Opoponax，和印度白檀粉。

The ventilatory responses of the peripheral chemoreflex following microinjection within the NA of either P2X receptor agonist adenosine triphosphate or antagonist pyridoxal-5′-phosphate-6-azo-phenyl-2, 4-disulfonate were observed.

结果 吸入低氧混合气后，动物呼吸加深加快；在NA处微量注射ATP增强了急性低氧呼吸频率，微量注射PPADS部分阻断了ATP对低氧通气的兴奋效应。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。