查询词典 agonist

RESULTS: We found that (1) tramadol, similar to the well-knownTRPV1 agonist, capsaicin, significantly increased [Ca2+] i ofTRPV1-CHO cells in a concentration-dependent fashion;(2) itseffect was reversibly prevented by the TRPV1 antagonist capsazepine;(3) repeated application of tramadol resulted in marked tachyphylaxis;and (4) tramadol did not modify [Ca2+] i in control CHO cells.

结果：我们发现以下结果：（1）曲马多和辣椒素这个熟知的辣椒素受体激动剂一样，呈浓度依赖性地显著增加 CHO 细胞 TRPV1内流钙离子；（2）该作用可以被 TRPV1拮抗剂 capsazepine 可逆性地阻止；（3）重复给予曲马多会造成显著的快速耐药性；（4）曲马多不修饰钙对照 CHO 细胞中的内流钙离子。

The results showed that (1) all the arteries tested had tachyphylaxis to peptidergic agonists;(2) the desensitization of the arteries tested to catecholamines was uneasy except BA;(3) the desensitizations to AⅡ, AVP and PE were homologous;(4) the endothelium-EDRF -cGMP pathway had no contribution to the tachyphylaxis of PA to AⅡ and AVP;(5) membrane receptor cycling (internaliation and re-insertion) contributed only in part to homologous desensitization;(6) there was no change in the function of voltage-dependent Ca〓 channel during desensitization to AⅡ and AVP;(7) some changes in G protein occurred during homologous desensitization;(8) the most surprising finding was that the caudal arterial smooth muscle of stroke-prone spontaneously hypertensive rat showed tachyphylaxis to α〓-adrenoceptor agonist PE, while the tachyphylaxis of pulmonary artery of SHR was not changed compared with that of Wistar rat.

脱敏是消除效应的一种有效方式。因此，研究不同血管对不同激动剂脱敏的差异及阐明脱敏的机制，有助于阐明血管活动个性化的机制。研究表明：血管对肽类激动剂的脱敏方式为快速脱敏，而对儿茶酚胺类激动剂不易脱敏；血管对肽类激动剂和儿茶酚胺类激动剂表现为同源脱敏；内皮-NO-cGMP通路不参与肺动脉对AⅡ和AVP的快速脱敏；用PAO抑制膜受体的内在化只能短暂抑制脱敏的发展，提示用膜受体数目的下调说不能完全解释同源脱敏；血管对AⅡ和AVP脱敏后VSMC细胞膜电压依赖性钙通道功能无改变；CA对AVP脱敏后GTPγS的量-效曲线下移，说明有G蛋白的变化，但这种变化并非G蛋白的亲和性改变；SHRsp之CA平滑肌对AⅡ和AVP的快速脱敏并未减弱，但对PE却表现为快速脱敏，这是我们首次发现的一个非常有趣的现象。

This includes certain medications such as theophylline, beta agonists and decongestants, especially prior to bedtime.

还包括一些药物，如茶碱、beta agonist和解充血药，尤其是在睡前服用。

Intuniv is a nonscheduled, selective,α-2A receptor agonist and has no known potential for abuse or dependence.

Intuniv是一种不定期服用的选择性α-2A 受体激动剂，尚未发现有药物滥用或依赖的情况。

According to correlative literatures, the diagnosis and treatment of bronchiolitis obliterans syndrome in three patients with hematological malignancies after allo-HSCT were analyzed. The function of haematopoiesis re-established successfully. The acute graft versus host disease did not occur in these patients except one patient occurred grade Ⅱ aGVHD, and the chronic graft versus host disease occurred in the 5th, 6th and 6th months after allo-HSCT respectively, but the cGVHD was recrudescent after treatment. The bronchiolitis obliterans syndrome occurred in the 9th, 7th and 11th months after allo-HSCT respectively, and they received the treatment of immunosuppressive, immune human serum globulin, azithromycin and to breathe in β2 receptor agonist and budesonide.

结合相关文献，对3例恶性血液病患者异基因造血干细胞移植后发生闭塞性细支气管炎综合征的临床特点和诊断治疗进行分析。3例患者移植后造血功能均顺利重建，2例未发生急性移植物抗宿主病，1例发生II度急性移植物抗宿主病；3例患者分别于移植后5，6，6个月发生广泛型慢性移植物抗宿主病，经治疗后病情仍有反复；3例患者分别于移植后9，7，11个月发生闭塞性细支气管炎综合征，给予免疫抑制剂、静脉免疫球蛋白、阿奇霉素及局部使用β2受体激动剂及布地奈德吸入治疗，2例在治疗4周后病情有所改善，另1例病情无改善。

Exendin-4 present in the salivary gland of the reptile, Gila monster, is a high-affinity agonist for the mammalian GLP-1 receptor.

Exendin-4是从希拉毒蜥蜴唾液中提取的多肽，对于哺乳动物GLP-1受体有高度亲和力。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。