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RESULTSdiabetic rats showed typical symptoms involving elevated serum glucose and weight loss (2)The rats in DM+VaD group reacted slower and made more error numbers in Y-maze than the rats in VaD group did, with a prolonged total reacting time in a whole day.(3)More neurons with serious damages, such as edema, ischemia or pyknosis could be found in DM+VaD group than in VaD group. More disarrangement of cone neurons, obvious glia proliferation, and more neuron apoptosis were found in CA area of hippocampus. CONCLUSIONS (1)2-VO in STZ-induced diabetic rats succeeded in establishing VaD animal models.(2) The cognitive dysfunction induced by VaD rats had been deteriorated by diabetes mellitus.(3)Morphology evidences proved that diabetes mellitus aggravated brain damages induced by VaD.PART II Effect of diabetes mellitus on the cholinergic nervous systemin CA1 area of hippocampus of VaDOBJECTIVE To estimate the role of cholinergic nervous system in hippocampus during the process of cognitive dysfunction aggravated by diabetes mellitus in DM+VaD group. METHODS Observe the changes of ChAT protein by immunohistochemistry stain. Chose three rats randomly from each group at each pointat two week, four week, and eight week, then sepa

经腹腔注射链脲佐菌素诱导慢性实验性糖尿病，1周后永久性结扎双侧颈总动脉(2-VO)制作VaD模型记录术后2周、4周和8周各组大鼠的体重及血糖；应用Y-迷宫检测空间定向学第二军医大学博士论文中…丈摘…要1ia；一色恤~﹁染澎糕行HE染色观察组织病理学孪叱；胶质细胞原纤维酸性蛋白protellZ，Cf冰尸标记观察星形胶质细舱的激活情况、橄声软公点娜育票票众糯黑橄居端粗默孺篇筑价井袱第二部分糖尿病对血管性痴呆大鼠海马c心区胆碱能神经系统的影响探讨海马CAI区胆碱能神经系统在糖尿病加重确D一大鼠认知障碍中所实验动物及分组同第一部分，应用免疫组织化学染色方法现察海马CAI{介狱牛第晕军l袭拔常博粗{论义

However, because of the complexity and the abstractness of the L/C, it has aggravated the difficulty of risk guard and finanicial supervision.

但是，由于信用证业务自身的复杂性和游离于基础合同的独立抽象性加重了风险防范和金融监管的难度。

He even formed a part of their misfortune, and he aggravated it.

他甚至是他们的苦难的因素，加深了他们的苦难。

But all night, night to the faster and faster, and he also aggravated the suffering.

但一切都晚了，黑夜来的越来越快了，他的痛苦也加重了。

This aggravated the crisis in the banking system.

这加剧了银行系统的危机。

Natural environment aggravated with the development of economy and technology.

随着经济和科技的发展，自然环境进一步地恶化。

The financial problem of this company is further aggravated by the rise in interest rates.

利率的提高使该公司的财务问题进一步恶化。

They found that the lack of rain aggravated the serious shortage of food.

他们发现，由于缺乏雨水，加剧了严重的粮食短缺。

In fact, the land market is in the aggravated changes.

事实上，目前的土地市场正处于加剧变动之中。

Kouhei:i don't know about that, but it seems i've aggravated her cold...

那我就不清楚了，但似乎我让她变的更冷酷了。

But this is impossible, as long as it is engaging in a market economy, there are risks in any operation.

但是，这是不可能的，只要是搞市场经济，是有风险的任何行动。

We're on the same wavelength.

我们是同道中人。