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The results showed that (1) COX-2 mRNA and protein existed in the mature male rat testis. COX-2 was localized in spermatocytes by immunohistochemistry.(2) COX-2 also existed in adult man testis. COX-2 protein was positively stained in spermatocytes and Leydig cells.(3) 2 weeks after administration of rofecoxib, the level of testosterone in the whole testis reached its lower values, being only 50% of control values. However, testosterone level recovered during 4 weeks. After such treatment, histologic examination of these testes showed atrophy of the seminiferous tubules and maturation arrest of spermatogenesis.(4) 2 weeks post-EDS, expression of COX-2 decreased significantly (P.005), in comparison with vehicle-treatment control. 4 weeks after treatment, a new generation of fetal like Leydig cells repopulated in the testicular interstitium resulting in COX-2 expression partially recovered. Although the expression of COX-2 mRNA and protein are enhanced at 8th week after using external testosterone, it wasn't significant higher than control group.

实验研究证明：(1)正常成年雄性大鼠睾丸组织中COX-2在mRNA和蛋白质水平均存在表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞；正常成年男性睾丸组织中同样存在COX-2表达，免疫组织化学结果显示COX-2定位于曲细精管内的生精细胞和Leydig细胞；(2)服用特异性COX-2酶抑制剂rofecoxib 2周后，实验组大鼠睾丸组织内睾酮的含量减少，为正常对照组的50％；持续用药4周后睾丸组织内睾酮浓度逐渐恢复至正常水平；COX-2酶活性降低后病理组织切片显示睾丸内曲细精管萎缩，生精紊乱，持续用药4周时影响最明显；(3)注射特异性Leydig细胞杀灭剂EDS 2周后，实验组大鼠睾丸组织内睾酮浓度降至极低水平时，COX-2的蛋白和基因表达水平也显著低于正常空白对照组（P.005）；使用EDS后第4周，睾丸组织中的睾酮浓度逐渐回升，同样组织中COX-2蛋白表达和mRNA表达水平也相应提高接近正常水平；使用EDS后4周开始给予外源性睾酮，6周和8周时COX-2表达水平的绝对值虽有提高，但与正常大鼠空白对照组比较并无显著性差异，说明外源性雄激素刺激睾丸合成COX-2的作用并不明显。

According to correlative literatures, the diagnosis and treatment of bronchiolitis obliterans syndrome in three patients with hematological malignancies after allo-HSCT were analyzed. The function of haematopoiesis re-established successfully. The acute graft versus host disease did not occur in these patients except one patient occurred grade Ⅱ aGVHD, and the chronic graft versus host disease occurred in the 5th, 6th and 6th months after allo-HSCT respectively, but the cGVHD was recrudescent after treatment. The bronchiolitis obliterans syndrome occurred in the 9th, 7th and 11th months after allo-HSCT respectively, and they received the treatment of immunosuppressive, immune human serum globulin, azithromycin and to breathe in β2 receptor agonist and budesonide.

结合相关文献，对3例恶性血液病患者异基因造血干细胞移植后发生闭塞性细支气管炎综合征的临床特点和诊断治疗进行分析。3例患者移植后造血功能均顺利重建，2例未发生急性移植物抗宿主病，1例发生II度急性移植物抗宿主病；3例患者分别于移植后5，6，6个月发生广泛型慢性移植物抗宿主病，经治疗后病情仍有反复；3例患者分别于移植后9，7，11个月发生闭塞性细支气管炎综合征，给予免疫抑制剂、静脉免疫球蛋白、阿奇霉素及局部使用β2受体激动剂及布地奈德吸入治疗，2例在治疗4周后病情有所改善，另1例病情无改善。

Think continually how many physicians are dead after often contracting their eyebrows over the sick; and how many astrologers after predicting with great pretensions the deaths of others; and how many philosophers after endless discourses on death or immortality; how many heroes after killing thousands; and how many tyrants who have used their power over men's lives with terrible insolence as if they were immortal; and how many cities are entirely dead, so to speak, Helice and Pompeii and Herculaneum, and others innumerable.

不断地想这些事：有多少医生在频繁地对病人皱拢眉头之后死去；有多少占星家在提前很久预告了别人的死亡之后也已死去；又有多少哲学家在不断地讨论死亡或不朽之后死去；多少英雄在杀了成千上万人之后死去；多少暴君，仿佛他们是不死的一样，在以可怕的蛮横手段使用他们对于人们生命的权力之后死去；又有多少城市，比如赫利斯、庞培、赫库莱尼恩以及别的不可计数的城市被完全毁灭。

We're sort of like 7-Eleven.

我们有点像24小时便利店

Some people think of the storage battery as a sort of condenser where electricity is stored.

有人以为蓄电池是一种储存电力的容器，但这种顾名思义的看法是完全错误的。

He is a good sort of body.

他是个好好先生。

In fact, it could be said that America, a British colony, is a sort of Britain metamorphosed into new shape.

事实上我们可以这样说，作为英国殖民地的美国是从英国演变而来的一种新形态。

It is very scary for me as I almost always have a cushion of some sort.

真是吓人，因为我以前口袋里总是有些备用钱的。

One of the reasons I like this concept is that I do think of it as a sort of fund or bank.

原因之一，我喜欢这个概念，就是我觉得它作为一种基金或银行。

This is done with the VC heap sort of a procedure, very suitable for the data structure used for the design.

这是用VC++做的一个堆排序的程序，非常适合用作数据结构的课程设计。

Listen,point and check your answers.

听，指出并且检查你的答案。

Warming needle is one of effective treatment methods for knee arthralgia aggravated by cold,and it is simple,safety,so it should be developed in clinical acupuncture and moxibustion extensively.

但以本院科针灸门诊在2005年1月—2006年6月期间共收治膝痛患者100余例，经过临床的诊断后，其中施以温针治疗的48例，疗效显著，报道如下。1临床资料本组病例48